Peter Hegemann

Evidence for a light-induced H(+) conductance in the eye of the green alga Chlamydomonas reinhardtii.

Channelrhodopsin-1: a light-gated proton channel in green algae.

Phot-LOV1: photocycle of a blue-light receptor domain from the green alga Chlamydomonas reinhardtii.

Crystal structures and molecular mechanism of a light-induced signaling switch: The Phot-LOV1 domain from Chlamydomonas reinhardtii.

Characterization of a flavin radical product in a C57M mutant of a LOV1 domain by electron paramagnetic resonance.

Irreversible photoreduction of flavin in a mutated Phot-LOV1 domain.

Channelrhodopsin-2, a directly light-gated cation-selective membrane channel.

Recording of blue light-induced energy and volume changes within the wild-type and mutated phot-LOV1 domain from Chlamydomonas reinhardtii.

"Vision" in single-celled algae.

On the reaction mechanism of adduct formation in LOV domains of the plant blue-light receptor phototropin.

Monitoring dynamic expression of nuclear genes in Chlamydomonas reinhardtii by using a synthetic luciferase reporter gene.

Removal of mismatched bases from synthetic genes by enzymatic mismatch cleavage.

The phot LOV2 domain and its interaction with LOV1.

Nuclear-gene targeting by using single-stranded DNA avoids illegitimate DNA integration in Chlamydomonas reinhardtii.

Multiple photocycles of channelrhodopsin.

Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin.

The photochemistry of the light-, oxygen-, and voltage-sensitive domains in the algal blue light receptor phot.

H+ -pumping rhodopsin from the marine alga Acetabularia.

Hydrogen-bond switching through a radical pair mechanism in a flavin-binding photoreceptor.

Fast manipulation of cellular cAMP level by light in vivo.

Redox properties of LOV domains: chemical versus photochemical reduction, and influence on the photocycle.

Photoactivation of channelrhodopsin.

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri.

Algal sensory photoreceptors.

Channelrhodopsin-1 initiates phototaxis and photophobic responses in chlamydomonas by immediate light-induced depolarization.

Dynamics of voltage profile in enzymatic ion transporters, demonstrated in electrokinetics of proton pumping rhodopsin.

Hydrogen bond switching among flavin and amino acid side chains in the BLUF photoreceptor observed by ultrafast infrared spectroscopy.

Monitoring light-induced structural changes of Channelrhodopsin-2 by UV-visible and Fourier transform infrared spectroscopy.

In vivo generation of flavoproteins with modified cofactors.

Bi-stable neural state switches.

Nuclear gene targeting in Chlamydomonas as exemplified by disruption of the PHOT gene.

Glu 87 of channelrhodopsin-1 causes pH-dependent color tuning and fast photocurrent inactivation.

Channelrhodopsins of Volvox carteri are photochromic proteins that are specifically expressed in somatic cells under control of light, temperature, and the sex inducer.

Mechanistic insights in light-induced cAMP production by photoactivated adenylyl cyclase alpha (PACalpha).

The role of key amino acids in the photoactivation pathway of the Synechocystis Slr1694 BLUF domain.

Blue light induces global and localized conformational changes in the kinase domain of full-length phototropin.

Ultrafast optogenetic control.

Two open states with progressive proton selectivities in the branched channelrhodopsin-2 photocycle.

The branched photocycle of the slow-cycling channelrhodopsin-2 mutant C128T.

Evolution of the channelrhodopsin photocycle model.

Hindered rotation of a cofactor methyl group as a probe for protein-cofactor interaction.

Fast, repetitive light-activation of CaV3.2 using channelrhodopsin 2.

Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa.

Channelrhodopsin engineering and exploration of new optogenetic tools.

Light-generated paramagnetic intermediates in BLUF domains.

Microbial opsins: a family of single-component tools for optical control of neural activity.

High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels.

Introduction to the Symposium-in Print: Blue light effects.

The hydrogen-bond switch reaction of the Blrb Bluf domain of Rhodobacter sphaeroides.

Neocortical excitation/inhibition balance in information processing and social dysfunction.

Rectification of the channelrhodopsin early conductance.

Color tuning in binding pocket models of the chlamydomonas-type channelrhodopsins.

The chromophore structure of the long-lived intermediate of the C128T channelrhodopsin-2 variant.

The microbial opsin family of optogenetic tools.

In channelrhodopsin-2 Glu-90 is crucial for ion selectivity and is deprotonated during the photocycle.

Structural model of channelrhodopsin.

Crystal structure of the channelrhodopsin light-gated cation channel.

Color-tuned channelrhodopsins for multiwavelength optogenetics.

A photochromic histidine kinase rhodopsin (HKR1) that is bimodally switched by ultraviolet and blue light.

Bimodal activation of different neuron classes with the spectrally red-shifted channelrhodopsin chimera C1V1 in Caenorhabditis elegans.

Nuclear gene targeting in Chlamydomonas using engineered zinc-finger nucleases.

Phototropin influence on eyespot development and regulation of phototactic behavior in Chlamydomonas reinhardtii.

From channelrhodopsins to optogenetics.

Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling.

Towards an understanding of channelrhodopsin function: simulations lead to novel insights of the channel mechanism.

Light-dark adaptation of channelrhodopsin C128T mutant.

Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics.

Adventure beyond borders of scientific fields with optogenetics.

Optogenetic modulation of an adenylate cyclase in Toxoplasma gondii demonstrates a requirement of the parasite cAMP for host-cell invasion and stage differentiation.

Ion selectivity and competition in channelrhodopsins.

Biotechnology: Programming genomes with light.

Of ion pumps, sensors and channels - perspectives on microbial rhodopsins between science and history.

Gloeobacter rhodopsin, limitation of proton pumping at high electrochemical load.

A set of engineered Escherichia coli expression strains for selective isotope and reactivity labeling of amino acid side chains and flavin cofactors.

Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.

Bistable retinal schiff base photodynamics of histidine kinase rhodopsin HKR1 from Chlamydomonas reinhardtii.

Conversion of channelrhodopsin into a light-gated chloride channel.

Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase.

Key residues for the light regulation of the blue light-activated adenylyl cyclase from Beggiatoa sp.

Absorption and emission spectroscopic characterization of photo-dynamics of photoactivated adenylyl cyclase mutant bPAC-Y7F of Beggiatoa sp.

Upgrading a microplate reader for photobiology and all-optical experiments.

Early formation of the ion-conducting pore in channelrhodopsin-2.

Controlling fertilization and cAMP signaling in sperm by optogenetics.

Photochemical chromophore isomerization in histidine kinase rhodopsin HKR1.

Biophysics of Channelrhodopsin.

Time-resolved infrared spectroscopic techniques as applied to channelrhodopsin.

Light-Dark Adaptation of Channelrhodopsin Involves Photoconversion between the all-trans and 13-cis Retinal Isomers.

The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling.

Photoactivated cyclases: In memoriam Masakatsu Watanabe.

Optogenetics: 10 years after ChR2 in neurons--views from the community.

An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo.

Optogenetic acidification of synaptic vesicles and lysosomes.

Light-Induced Rearrangement of the β5 Strand in the BLUF Photoreceptor SyPixD (Slr1694).

Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity.

Identification of a Natural Green Light Absorbing Chloride Conducting Channelrhodopsin from Proteomonas sulcata.

Optogenetic approaches addressing extracellular modulation of neural excitability.

Unfolding of the C-Terminal Jα Helix in the LOV2 Photoreceptor Domain Observed by Time-Resolved Vibrational Spectroscopy.

A blue-light photoreceptor mediates the feedback regulation of photosynthesis.

Photoadduct Formation from the FMN Singlet Excited State in the LOV2 Domain of Chlamydomonas reinhardtii Phototropin.

Active cortical dendrites modulate perception.

An Efficient Visual Screen for CRISPR/Cas9 Activity in Arabidopsis thaliana.

Complex Photochemistry within the Green-Absorbing Channelrhodopsin ReaChR.