intranasal-delivery-therapeutic-stem-cells-to-glioblastoma-mouse

Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model

The intrinsic tropism towards brain malignancies renders stem cells as promising carriers of therapeutic agents against malignant tumors. The delivery of ...

Northwestern University

One-pot, 18-component synthesis of an octahedral nanocontainer molecule.

The challenges to effective drug delivery to brain tumors are twofold: (1) there is a lack of non-invasive methods of local delivery and (2) the blood-brain barrier limits systemic delivery. Intranasal delivery of therapeutics to the brain overcomes both challenges. In mouse model of malignant glioma, we observed that a small fraction of intranasally delivered neural stem cells (NSCs) can migrate to the brain tumor site. Here, we demonstrate that hypoxic preconditioning or overexpression of CXCR4 significantly enhances the tumor-targeting ability of NSCs, but without altering their phenotype only in genetically modified NSCs. Modified NSCs deliver oncolytic virus to glioma more efficiently and extend survival of experimental animals in the context of radiotherapy. Our findings indicate that intranasal delivery of stem cell-based therapeutics could be optimized for future clinical applications, and allow for safe and repeated administration of biological therapies to brain tumors and other CNS disorders.

Gina Li

Department of Neurological Surgery,
Feinberg School of Medicine,
Department of Neurological Surgery, Feinberg School of Medicine

Northwestern University

Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model

Gina Li

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Neurological Surgery,Feinberg School of Medicine,Department of Neurological Surgery, Feinberg School of Medicine

Northwestern University

Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model

Department of Neurological Surgery,
Feinberg School of Medicine,
Department of Neurological Surgery, Feinberg School of Medicine