Institute of Molecular Oncology,
Advanced Cancer Translational Research Institute
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Induction of differentiation in normal human keratinocytes by adenovirus-mediated introduction of the eta and delta isoforms of protein kinase C.
Molecular and cellular biology Sep, 1998 | Pubmed ID: 9710604
Phorbol ester-induced G1 arrest in BALB/MK-2 mouse keratinocytes is mediated by delta and eta isoforms of protein kinase C.
Japanese journal of cancer research : Gann Nov, 1998 | Pubmed ID: 9914781
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha.
The Journal of biological chemistry Jan, 2002 | Pubmed ID: 11584014
Activation of protein kinase C zeta induces serine phosphorylation of VAMP2 in the GLUT4 compartment and increases glucose transport in skeletal muscle.
Molecular and cellular biology Nov, 2001 | Pubmed ID: 11604519
Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells.
The Journal of biological chemistry Mar, 2002 | Pubmed ID: 11744693
Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2.
Molecular endocrinology (Baltimore, Md.) Feb, 2002 | Pubmed ID: 11818507
Lysophosphatidylcholine inhibits insulin-induced Akt activation through protein kinase C-alpha in vascular smooth muscle cells.
Hypertension (Dallas, Tex. : 1979) Feb, 2002 | Pubmed ID: 11882599
Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells.
The Journal of clinical investigation Mar, 2002 | Pubmed ID: 11901191
Dual regulation of phospholipase D1 by protein kinase C alpha in vivo.
Biochemical and biophysical research communications Jun, 2002 | Pubmed ID: 12074591
Novel protein kinase C isoforms regulate human keratinocyte differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha.
The Journal of biological chemistry Aug, 2002 | Pubmed ID: 12080077
Enhancement of anchorage-independent growth of human pancreatic carcinoma MIA PaCa-2 cells by signaling from protein kinase C to mitogen-activated protein kinase.
Molecular carcinogenesis Aug, 2002 | Pubmed ID: 12203369
Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src.
The Journal of biological chemistry Nov, 2002 | Pubmed ID: 12226102
Localization of phospholipase D1 to caveolin-enriched membrane via palmitoylation: implications for epidermal growth factor signaling.
Molecular biology of the cell Nov, 2002 | Pubmed ID: 12429840
Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation.
The Journal of biological chemistry Jan, 2003 | Pubmed ID: 12431976
Protein kinase C eta (PKC eta): its involvement in keratinocyte differentiation.
Journal of biochemistry Dec, 2002 | Pubmed ID: 12473186
Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: role of metalloprotease and protein kinase C-delta.
Molecular and cellular biology Mar, 2003 | Pubmed ID: 12588978
Insulin-induced Akt activation is inhibited by angiotensin II in the vasculature through protein kinase C-alpha.
Hypertension (Dallas, Tex. : 1979) Mar, 2003 | Pubmed ID: 12623995
The eta isoform of protein kinase C inhibits UV-induced activation of caspase-3 in normal human keratinocytes.
Biochemical and biophysical research communications Mar, 2003 | Pubmed ID: 12646210
PKCdelta inhibits PKCalpha-mediated activation of phospholipase D1 in a manner independent of its protein kinase activity.
FEBS letters Nov, 2003 | Pubmed ID: 14596936
Differential regulation of alpha6beta4 integrin by PKC isoforms in murine skin keratinocytes.
Biochemical and biophysical research communications Jan, 2004 | Pubmed ID: 14715240
PKCalpha mediates TGFbeta-induced growth inhibition of human keratinocytes via phosphorylation of S100C/A11.
The Journal of cell biology Mar, 2004 | Pubmed ID: 15051732
Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation.
Journal of molecular biology Jul, 2004 | Pubmed ID: 15223313
Role of CPI-17 in the regulation of endothelial cytoskeleton.
American journal of physiology. Lung cellular and molecular physiology Nov, 2004 | Pubmed ID: 15234908
Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells.
The Journal of biological chemistry Sep, 2004 | Pubmed ID: 15280372
Decay-accelerating factor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-alpha/epsilon (PKCalpha/epsilon)-dependent cytoprotective signaling pathway and is inhibited by cyclosporin A.
The Journal of biological chemistry Oct, 2004 | Pubmed ID: 15284224
Angiotensin II-induced protein kinase D activation is regulated by protein kinase Cdelta and mediated via the angiotensin II type 1 receptor in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology Dec, 2004 | Pubmed ID: 15499041
Protein kinase Calpha is implicated in cholecystokinin-induced activation of 70-kd S6 kinase in AR42J cells.
Pancreas Jan, 2005 | Pubmed ID: 15632699
Novel functions of the phospholipase D2-Phox homology domain in protein kinase Czeta activation.
Molecular and cellular biology Apr, 2005 | Pubmed ID: 15798205
A role for proteinase-activated receptor 2 and PKC-epsilon in thrombin-mediated induction of decay-accelerating factor on human endothelial cells.
American journal of physiology. Cell physiology Dec, 2005 | Pubmed ID: 16079188
Pituitary adenylate cyclase-activating polypeptide-induced differentiation of embryonic neural stem cells into astrocytes is mediated via the beta isoform of protein kinase C.
Journal of neuroscience research Dec, 2006 | Pubmed ID: 17022039
Activation of protein kinase Czeta mediates luteinizing hormone- or forskolin-induced NGFI-B expression in preovulatory granulosa cells of rat ovary.
Molecular and cellular endocrinology May, 2007 | Pubmed ID: 17416458
A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2.
The Journal of biological chemistry Nov, 2007 | Pubmed ID: 17785460
Protein kinase C alpha and zeta differentially regulate death-inducing signaling complex formation in cigarette smoke extract-induced apoptosis.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2008 | Pubmed ID: 18354190
Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis.
The Journal of investigative dermatology Mar, 2009 | Pubmed ID: 18830271
Lysophosphatidylcholine activates adipocyte glucose uptake and lowers blood glucose levels in murine models of diabetes.
The Journal of biological chemistry Dec, 2009 | Pubmed ID: 19815546
Activation of proteinase-activated receptor 2 stimulates soluble vascular endothelial growth factor receptor 1 release via epidermal growth factor receptor transactivation in endothelial cells.
Hypertension Mar, 2010 | Pubmed ID: 20124108
Protein kinase C delta and eta differently regulate the expression of loricrin and Jun family proteins in human keratinocytes.
Biochemical and biophysical research communications Mar, 2010 | Pubmed ID: 20184865
B lymphocyte-induced maturation protein 1 is a novel target gene of aryl hydrocarbon receptor.
Journal of dermatological science Jun, 2010 | Pubmed ID: 20478695
Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C ε-mediated zona occludens-1 phosphorylation at threonine 770/772.
The Journal of biological chemistry Feb, 2014 | Pubmed ID: 24338688
Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients.
Scientific reports May, 2015 | Pubmed ID: 25994878
Acquired Resistance Mechanisms to Combination Met-TKI/EGFR-TKI Exposure in Met-Amplified EGFR-TKI-Resistant Lung Adenocarcinoma Harboring an Activating EGFR Mutation.
Molecular cancer therapeutics Dec, 2016 | Pubmed ID: 27612490
Distinct Afatinib Resistance Mechanisms Identified in Lung Adenocarcinoma Harboring an EGFR Mutation.
Molecular cancer research : MCR Jul, 2017 | Pubmed ID: 28289161
Up-regulation of Syndecan-4 contributes to TGF-β1-induced epithelial to mesenchymal transition in lung adenocarcinoma A549 cells.
Biochemistry and biophysics reports Mar, 2016 | Pubmed ID: 28955801
Molecular-Targeted Therapies for Epidermal Growth Factor Receptor and Its Resistance Mechanisms.
International journal of molecular sciences Nov, 2017 | Pubmed ID: 29140271
and Amplifications Mediate Resistance to Rociletinib and Osimertinib in Acquired Afatinib-Resistant NSCLC Harboring Exon 19 Deletion/T790M in .
Molecular cancer therapeutics 01, 2019 | Pubmed ID: 30322949
Receptor Tyrosine Kinase-Targeted Cancer Therapy.
International journal of molecular sciences Nov, 2018 | Pubmed ID: 30404198
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