Ronald L. Klein

Neuropathological and behavioral consequences of adeno-associated viral vector-mediated continuous intrastriatal neurotrophin delivery in a focal ischemia model in rats.

Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra.

Dose and promoter effects of adeno-associated viral vector for green fluorescent protein expression in the rat brain.

Pre- and post-synaptic modification by neurotrophins.

Gene delivery to the eye using adeno-associated viral vectors.

Measurements of vector-derived neurotrophic factor and green fluorescent protein levels in the brain.

Particle detection, number estimation, and feature measurement in gene transfer studies: optical fractionator stereology integrated with digital image processing and analysis.

Suppression of insult-induced neurogenesis in adult rat brain by brain-derived neurotrophic factor.

Adeno-associated virus vector expressing nerve growth factor enhances cholinergic axonal sprouting after cortical injury in rats.

Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model.

Long-term neuronal effects and disposition of ectopic preproNGF gene transfer into the rat septum.

Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.

Recombinant adeno-associated virus serotype 2 effectively transduces primary rat brain astrocytes and microglia.

Adeno-associated viruses containing bFGF or BDNF are neuroprotective against excitotoxicity.

Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat.

Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins.

Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model.

Memory-related deficits following selective hippocampal expression of Swedish mutation amyloid precursor protein in the rat.

AAV8, 9, Rh10, Rh43 vector gene transfer in the rat brain: effects of serotype, promoter and purification method.

Tau expression levels from various adeno-associated virus vector serotypes produce graded neurodegenerative disease states.

Effect of CNTF on retinal ganglion cell survival in experimental glaucoma.

Pronounced microgliosis and neurodegeneration in aged rats after tau gene transfer.

Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression.

PET imaging in rats to discern temporal onset differences between 6-hydroxydopamine and tau gene vector neurodegeneration models.

Bilateral effects of unilateral GDNF administration on dopamine- and GABA-regulating proteins in the rat nigrostriatal system.

Versatile somatic gene transfer for modeling neurodegenerative diseases.

Transcriptome analysis of a tau overexpression model in rats implicates an early pro-inflammatory response.

Circulating neprilysin clears brain amyloid.

Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory.

Expansive gene transfer in the rat CNS rapidly produces amyotrophic lateral sclerosis relevant sequelae when TDP-43 is overexpressed.

Genetic strategies to study TDP-43 in rodents and to develop preclinical therapeutics for amyotrophic lateral sclerosis.

Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus.

The advent of AAV9 expands applications for brain and spinal cord gene delivery.

Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase.

Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats.

A spirulina-enhanced diet provides neuroprotection in an α-synuclein model of Parkinson's disease.

Imaging the response of the retina to electrical stimulation with genetically encoded calcium indicators.

Recombinant AAV9-TLK1B administration ameliorates fractionated radiation-induced xerostomia.

Pre-immunization with an Intramuscular Injection of AAV9-Human Erythropoietin Vectors Reduces the Vector-Mediated Transduction following Re-Administration in Rat Brain.

Selective forelimb impairment in rats expressing a pathological TDP-43 25 kDa C-terminal fragment to mimic amyotrophic lateral sclerosis.

Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates.

AAV9 supports wide-scale transduction of the CNS and TDP-43 disease modeling in adult rats.

Sequential Adeno-Associated Viral Vector Serotype 9-Green Fluorescent Protein Gene Transfer Causes Massive Inflammation and Intense Immune Response in Rat Striatum.

Gene vector 'magic bullet': targeted expression in the central nervous system after peripheral delivery using the synapsin promoter.

Severe respiratory changes at end stage in a FUS-induced disease state in adult rats.

Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B.

Corrigendum: Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B.

p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration.

Selective Forelimb Impairment in Rats Expressing a Pathological TDP-43 25 kDa C-terminal Fragment to Mimic Amyotrophic Lateral Sclerosis.

Entorhinal tau pathology disrupts hippocampal-prefrontal oscillatory coupling during associative learning.