George K. Michalopoulos

Cationic colloidal silica membrane perturbation as a means of examining changes at the sinusoidal surface during liver regeneration.

Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growth.

The processing and utilization of hepatocyte growth factor/scatter factor following partial hepatectomy in the rat.

Histological organization in hepatocyte organoid cultures.

Differential mitogenic effects of single chain hepatocyte growth factor (HGF)/scatter factor and HGF/NK1 following cleavage by factor Xa.

Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures.

Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification.

Gene expression analysis of human soft tissue leiomyosarcomas.

PPARgamma ligands inhibit cholangiocarcinoma cell growth through p53-dependent GADD45 and p21 pathway.

HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures.

Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis.

Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration.

Liver regeneration, growth factors, and amphiregulin.

Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury.

Liver regeneration.

Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells.

Distinctive role of Stat3 and Erk-1/2 activation in mediating interferon-gamma inhibition of TGF-beta1 action.

Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation.

Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR.

Flexible lineage specifications of adult hepatic cells, associated molecular pathways, and their relationship to liver cancer.

Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.

Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas.

Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation.

Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis.

Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference.

Liver regeneration.

Promotion of Fas-mediated apoptosis in Type II cells by high doses of hepatocyte growth factor bypasses the mitochondrial requirement.

Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes.

Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development.

Mechanisms of hepatocyte growth factor-mediated and epidermal growth factor-mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium.

Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling.

Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development.

Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly.

Investigation of the role of glypican 3 in liver regeneration and hepatocyte proliferation.

Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase.

Liver regeneration: alternative epithelial pathways.

Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility.

Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas.

Interaction of integrin-linked kinase and miniature chromosome maintenance 7-mediating integrin {alpha}7 induced cell growth suppression.

Bid agonist regulates murine hepatocyte proliferation by controlling endoplasmic reticulum calcium homeostasis.

Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition of primary and transformed hepatocyte growth.

Suppression of liver regeneration and hepatocyte proliferation in hepatocyte-targeted glypican 3 transgenic mice.

Expression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-biliary epithelial cell transdifferentiation.

Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene.

Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice.

Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo.

A mouse model of accelerated liver aging caused by a defect in DNA repair.

Protection against Fas-induced fulminant hepatic failure in liver specific integrin linked kinase knockout mice.

Gene deletions and amplifications in human hepatocellular carcinomas: correlation with hepatocyte growth regulation.

Expression of hepatocyte epidermal growth factor receptor, FAS and glypican 3 in EpCAM-positive regenerative clusters of hepatocytes, cholangiocytes, and progenitor cells in human liver failure.

Gliotoxin-induced changes in rat liver regeneration after partial hepatectomy.

Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex.

Principles of liver regeneration and growth homeostasis.

Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis.

The degree of segmental aneuploidy measured by total copy number abnormalities predicts survival and recurrence in superficial gastroesophageal adenocarcinoma.

The liver is a peculiar organ when it comes to stem cells.

Signals and cells involved in regulating liver regeneration.

Development of a chemically defined medium and discovery of new mitogenic growth factors for mouse hepatocytes: mitogenic effects of FGF1/2 and PDGF.

Advances in liver regeneration.

Novel fusion transcripts associate with progressive prostate cancer.

Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1.

Liver-Specific Deletion of Integrin-Linked Kinase in Mice Attenuates Hepatotoxicity and Improves Liver Regeneration After Acetaminophen Overdose.

Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers.

Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation.

Bile Duct Ligation Induces ATZ Globule Clearance in a Mouse Model of α-1 Antitrypsin Deficiency.

MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice.

Immunohistochemical Analysis of the Stem Cell Marker LGR5 in Pediatric Liver Disease.

Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene.

Dose-dependent biphasic effects of phenobarbital on growth and differentiation of primary culture rat hepatocytes.

Oct4 Is Crucial for Transdifferentiation of Hepatocytes to Biliary Epithelial Cells in an In Vitro Organoid Culture Model.

Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice.