Maiken Nedergaard

P2X7 receptor inhibition improves recovery after spinal cord injury.

Role of glial cells in cerebral ischemia.

An astrocytic basis of epilepsy.

Receptor-mediated glutamate release from volume sensitive channels in astrocytes.

Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo.

Astrocytic complexity distinguishes the human brain.

Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brain.

Purinergic signaling regulates neural progenitor cell expansion and neurogenesis.

Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease.

Cortical spreading depression causes and coincides with tissue hypoxia.

Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes.

The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex.

Loss of astrocytic domain organization in the epileptic brain.

Connexin 43 hemichannels are permeable to ATP.

Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse.

Astrocytic calcium signaling: mechanism and implications for functional brain imaging.

Astrocytes and ischemic injury.

Physiological and pathological functions of P2X7 receptor in the spinal cord.

Uniquely hominid features of adult human astrocytes.

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury.

Glial calcium and diseases of the nervous system.

Calcium dyshomeostasis and pathological calcium signalling in neurological diseases.

Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i.

Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.

Sulforhodamine 101 induces long-term potentiation of intrinsic excitability and synaptic efficacy in hippocampal CA1 pyramidal neurons.

Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions.

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.

Cultured astrocytes do not release adenosine during hypoxic conditions.

Heterogeneity of astrocytic form and function.

Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury.

Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity.

Alexander disease.

The locus coeruleus-norepinephrine network optimizes coupling of cerebral blood volume with oxygen demand.

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

Molecular scaffolds underpinning macroglial polarization: an analysis of retinal Müller cells and brain astrocytes in mouse.

General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex.

Glial progenitor cell-based treatment and modeling of neurological disease.

Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts.

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI.

'Hit & Run' model of closed-skull traumatic brain injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation.

Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.

In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression.

Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer.

Is there a cerebral lymphatic system?

Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease.

Neuroscience. Garbage truck of the brain.

Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain.

Sleep drives metabolite clearance from the adult brain.

α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice.

Photolysis of caged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release.

Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain.

White matter astrocytes in health and disease.

Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices.

P2X receptors in neuroglia.

Contributions of the Na⁺/K⁺-ATPase, NKCC1, and Kir4.1 to hippocampal K⁺ clearance and volume responses.

A novel technique for morphometric quantification of subarachnoid hemorrhage-induced microglia activation.

The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy.

Effects of traumatic brain injury on reactive astrogliosis and seizures in mouse models of Alexander disease.

Fine-tuning the central nervous system: microglial modelling of cells and synapses.

Drowning stars: reassessing the role of astrocytes in brain edema.

Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.

How do astrocytes participate in neural plasticity?

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease.

Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system.

The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy.

Modern cerebrospinal fluid flow research and Heinrich Quincke's seminal 1872 article on the distribution of cinnabar in freely moving animals.

Why have we not yet developed a simple blood test for TBI?

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.

The Glymphatic System: A Beginner's Guide.

Filtering the muddied waters of brain edema.

Modeling cognition and disease using human glial chimeric mice.

A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone.

Implications of the discovery of brain lymphatic pathways.

Cerebral microcirculatory failure after subarachnoid hemorrhage is reversed by hyaluronidase.

Ultra-fast magnetic resonance encephalography of physiological brain activity - Glymphatic pulsation mechanisms?

Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.

Changes in the composition of brain interstitial ions control the sleep-wake cycle.

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease.

Human glia can both induce and rescue aspects of disease phenotype in Huntington disease.

Impairment of the glymphatic system after diabetes.

The homeostatic astroglia emerges from evolutionary specialization of neural cells.

Sulforhodamine 101, a widely used astrocyte marker, can induce cortical seizure-like activity at concentrations commonly used.

Glymphatic clearance controls state-dependent changes in brain lactate concentration.

Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation.

A Novel Model of Transient Occlusion of the Middle Cerebral Artery in Awake Mice.

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts.

Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?

Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET.

SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions.

Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T.

Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.

Perivascular spaces, glymphatic dysfunction, and small vessel disease.

Do Evolutionary Changes in Astrocytes Contribute to the Computational Power of the Hominid Brain?

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics.

Brain energetics during the sleep-wake cycle.

Voluntary running enhances glymphatic influx in awake behaving, young mice.

The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future.

Physiology of Astroglia.

Fluorescent Ca indicators directly inhibit the Na,K-ATPase and disrupt cellular functions.

Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function.

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Understanding the role of the perivascular space in cerebral small vessel disease.

Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.

The glymphatic pathway in neurological disorders.

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.

Aquaporin-4-dependent glymphatic solute transport in the rodent brain.

Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia.

Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs.

Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke.

When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow.

Oxygen tension-mediated erythrocyte membrane interactions regulate cerebral capillary hyperemia.

Impaired Glymphatic Transport in Spontaneously Hypertensive Rats.

Hydraulic resistance of periarterial spaces in the brain.

Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling.

Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas.

Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease.