Chair of Bioprocess Engineering,
Department of Biotechnology,
Chair of Bioprocess Engineering, Department of Biotechnology
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Norvaline is accumulated after a down-shift of oxygen in Escherichia coli W3110.
Microbial cell factories Oct, 2008 | Pubmed ID: 18940002
Enzyme controlled glucose auto-delivery for high cell density cultivations in microplates and shake flasks.
Microbial cell factories Nov, 2008 | Pubmed ID: 19017379
A novel fed-batch based cultivation method provides high cell-density and improves yield of soluble recombinant proteins in shaken cultures.
Microbial cell factories Feb, 2010 | Pubmed ID: 20167131
Scale-down simulators for metabolic analysis of large-scale bioprocesses.
Current opinion in biotechnology Feb, 2010 | Pubmed ID: 20185293
Novel approach of high cell density recombinant bioprocess development: optimisation and scale-up from microliter to pilot scales while maintaining the fed-batch cultivation mode of E. coli cultures.
Microbial cell factories May, 2010 | Pubmed ID: 20487563
Quality control of inclusion bodies in Escherichia coli.
Microbial cell factories May, 2010 | Pubmed ID: 20509924
High cell density cultivation and recombinant protein production with Escherichia coli in a rocking-motion-type bioreactor.
Microbial cell factories , 2010 | Pubmed ID: 20509968
Sandwich ELISA for quantitative detection of human collagen prolyl 4-hydroxylase.
Microbial cell factories Jun, 2010 | Pubmed ID: 20565744
Complete genome sequence of the lytic Pseudomonas fluorescens phage ϕIBB-PF7A.
Virology journal Mar, 2011 | Pubmed ID: 21439081
Reducing conditions are the key for efficient production of active ribonuclease inhibitor in Escherichia coli.
Microbial cell factories May, 2011 | Pubmed ID: 21554746
Enhanced growth and recombinant protein production of Escherichia coli by a perfluorinated oxygen carrier in miniaturized fed-batch cultures.
Microbial cell factories Jun, 2011 | Pubmed ID: 21708024
Two-compartment method for determination of the oxygen transfer rate with electrochemical sensors based on sulfite oxidation.
Biotechnology journal Aug, 2011 | Pubmed ID: 21751399
A two-compartment bioreactor system made of commercial parts for bioprocess scale-down studies: impact of oscillations on Bacillus subtilis fed-batch cultivations.
Biotechnology journal Aug, 2011 | Pubmed ID: 21751400
Heterologous production of active ribonuclease inhibitor in Escherichia coli by redox state control and chaperonin coexpression.
Microbial cell factories Aug, 2011 | Pubmed ID: 21824411
High-temperature cultivation and 5' mRNA optimization are key factors for the efficient overexpression of thermostable Deinococcus geothermalis purine nucleoside phosphorylase in Escherichia coli.
Journal of biotechnology Dec, 2011 | Pubmed ID: 21871934
Glucose-limited high cell density cultivations from small to pilot plant scale using an enzyme-controlled glucose delivery system.
New biotechnology Jan, 2012 | Pubmed ID: 22100433
High-yield production of biologically active recombinant protein in shake flask culture by combination of enzyme-based glucose delivery and increased oxygen transfer.
Microbial cell factories Dec, 2011 | Pubmed ID: 22152005
Enhanced plasmid production in miniaturized high-cell-density cultures of Escherichia coli supported with perfluorinated oxygen carrier.
Bioprocess and biosystems engineering Aug, 2013 | Pubmed ID: 23178986
Recombinant purine nucleoside phosphorylases from thermophiles: preparation, properties and activity towards purine and pyrimidine nucleosides.
The FEBS journal Mar, 2013 | Pubmed ID: 23332162
Recombinant protein production: a comparative view on host physiology (Laupheim, Germany, March 2013).
New biotechnology Jun, 2013 | Pubmed ID: 23770265
Cultivation of marine microorganisms in single-use systems.
Advances in biochemical engineering/biotechnology , 2014 | Pubmed ID: 23893044
Effect of culture medium, host strain and oxygen transfer on recombinant Fab antibody fragment yield and leakage to medium in shaken E. coli cultures.
Microbial cell factories Jul, 2013 | Pubmed ID: 23895637
Lactose autoinduction with enzymatic glucose release: characterization of the cultivation system in bioreactor.
Protein expression and purification Feb, 2014 | Pubmed ID: 24215862
Reconstituted biosynthesis of the nonribosomal macrolactone antibiotic valinomycin in Escherichia coli.
ACS synthetic biology Jul, 2014 | Pubmed ID: 24350980
Process inhomogeneity leads to rapid side product turnover in cultivation of Corynebacterium glutamicum.
Microbial cell factories Jan, 2014 | Pubmed ID: 24410842
Enhanced production of the nonribosomal peptide antibiotic valinomycin in Escherichia coli through small-scale high cell density fed-batch cultivation.
Applied microbiology and biotechnology Jan, 2014 | Pubmed ID: 24419900
Quantitative and sensitive RNA based detection of Bacillus spores.
Frontiers in microbiology , 2014 | Pubmed ID: 24653718
Escherichia coli as a cell factory for heterologous production of nonribosomal peptides and polyketides.
New biotechnology Dec, 2014 | Pubmed ID: 24704144
Identification and characterization of RNA guanine-quadruplex binding proteins.
Nucleic acids research Jun, 2014 | Pubmed ID: 24771345
Investigation of Phenolic Acids in Suspension Cultures of Vitis vinifera Stimulated with Indanoyl-Isoleucine, N-Linolenoyl-L-Glutamine, Malonyl Coenzyme A and Insect Saliva.
Metabolites Feb, 2012 | Pubmed ID: 24957372
Robotic platform for parallelized cultivation and monitoring of microbial growth parameters in microwell plates.
Journal of laboratory automation Dec, 2014 | Pubmed ID: 25208534
Type II thioesterase improves heterologous biosynthesis of valinomycin in Escherichia coli.
Journal of biotechnology Jan, 2015 | Pubmed ID: 25449019
Toward Microbioreactor Arrays: A Slow-Responding Oxygen Sensor for Monitoring of Microbial Cultures in Standard 96-Well Plates.
Journal of laboratory automation Aug, 2015 | Pubmed ID: 25720599
Response of Corynebacterium glutamicum exposed to oscillating cultivation conditions in a two- and a novel three-compartment scale-down bioreactor.
Biotechnology and bioengineering Jun, 2015 | Pubmed ID: 25728062
Structure-based directed evolution of a monomeric triosephosphate isomerase: toward a pentose sugar isomerase.
Protein engineering, design & selection : PEDS Jun, 2015 | Pubmed ID: 25767111
Scale-up bioprocess development for production of the antibiotic valinomycin in Escherichia coli based on consistent fed-batch cultivations.
Microbial cell factories Jun, 2015 | Pubmed ID: 26063334
An improved HPLC-DAD method for clavulanic acid quantification in fermentation broths of Streptomyces clavuligerus.
Journal of pharmaceutical and biomedical analysis Feb, 2016 | Pubmed ID: 26760242
Inversion of the stereochemical configuration (3S, 5S)-clavaminic acid into (3R, 5R)-clavulanic acid: A computationally-assisted approach based on experimental evidence.
Journal of theoretical biology Apr, 2016 | Pubmed ID: 26835563
Lanthipeptides: chemical synthesis versus in vivo biosynthesis as tools for pharmaceutical production.
Microbial cell factories Jun, 2016 | Pubmed ID: 27267232
Crystal structures of two monomeric triosephosphate isomerase variants identified via a directed-evolution protocol selecting for L-arabinose isomerase activity.
Acta crystallographica. Section F, Structural biology communications 06, 2016 | Pubmed ID: 27303904
The fed-batch principle for the molecular biology lab: controlled nutrient diets in ready-made media improve production of recombinant proteins in Escherichia coli.
Microbial cell factories Jun, 2016 | Pubmed ID: 27317421
Life cycle assessment of flexibly fed biogas processes for an improved demand-oriented biogas supply.
Bioresource technology Nov, 2016 | Pubmed ID: 27522120
Pharmacological and pharmacokinetic properties of lanthipeptides undergoing clinical studies.
Biotechnology letters Apr, 2017 | Pubmed ID: 28044226
Erratum to: Pharmacological and pharmacokinetic properties of lanthipeptides undergoing clinical studies.
Biotechnology letters 04, 2017 | Pubmed ID: 28155176
Micro-Electromechanical Affinity Sensor for the Monitoring of Glucose in Bioprocess Media.
International journal of molecular sciences Jun, 2017 | Pubmed ID: 28594350
Sterol synthesis and cell size distribution under oscillatory growth conditions in Saccharomyces cerevisiae scale-down cultivations.
Yeast (Chichester, England) 02, 2018 | Pubmed ID: 28940694
Bare laser-synthesized Au-based nanoparticles as nondisturbing surface-enhanced Raman scattering probes for bacteria identification.
Journal of biophotonics 07, 2018 | Pubmed ID: 29388744
Streptomyces clavuligerus shows a strong association between TCA cycle intermediate accumulation and clavulanic acid biosynthesis.
Applied microbiology and biotechnology May, 2018 | Pubmed ID: 29523936
How scalable and suitable are single-use bioreactors?
Current opinion in biotechnology 10, 2018 | Pubmed ID: 29753977
Real-time monitoring of the budding index in Saccharomyces cerevisiae batch cultivations with in situ microscopy.
Microbial cell factories May, 2018 | Pubmed ID: 29764434
Importance of the cultivation history for the response of Escherichia coli to oscillations in scale-down experiments.
Bioprocess and biosystems engineering Sep, 2018 | Pubmed ID: 29808419
Synthesis of non-canonical branched-chain amino acids in Escherichia coli and approaches to avoid their incorporation into recombinant proteins.
Current opinion in biotechnology 10, 2018 | Pubmed ID: 29870877
Comparison of time-gated surface-enhanced raman spectroscopy (TG-SERS) and classical SERS based monitoring of Escherichia coli cultivation samples.
Biotechnology progress 11, 2018 | Pubmed ID: 29882305
An observational study of ballooning in large spiders: Nanoscale multifibers enable large spiders' soaring flight.
PLoS biology 06, 2018 | Pubmed ID: 29902191
Application of Continuous Culture Methods to Recombinant Protein Production in Microorganisms.
Microorganisms Jun, 2018 | Pubmed ID: 29933583
Automated Cell Treatment for Competence and Transformation of in a High-Throughput Quasi-Turbidostat Using Microtiter Plates.
Microorganisms Jun, 2018 | Pubmed ID: 29941834
Bioinspired Designs, Molecular Premise and Tools for Evaluating the Ecological Importance of Antimicrobial Peptides.
Pharmaceuticals (Basel, Switzerland) Jul, 2018 | Pubmed ID: 29996512
Heterologous Biosynthesis, Modifications and Structural Characterization of Ruminococcin-A, a Lanthipeptide From the Gut Bacterium E1, in .
Frontiers in microbiology , 2018 | Pubmed ID: 30093894
Rocking Aspergillus: morphology-controlled cultivation of Aspergillus niger in a wave-mixed bioreactor for the production of secondary metabolites.
Microbial cell factories Aug, 2018 | Pubmed ID: 30129427
CFD predicted pH gradients in lactic acid bacteria cultivations.
Biotechnology and bioengineering Apr, 2019 | Pubmed ID: 30450609
Accelerated Bioprocess Development of Endopolygalacturonase-Production with Using Multivariate Prediction in a 48 Mini-Bioreactor Automated Platform.
Bioengineering (Basel, Switzerland) Nov, 2018 | Pubmed ID: 30469407
Electrooptical Determination of Polarizability for On-Line Viability and Vitality Quantification of Cultures.
Frontiers in bioengineering and biotechnology , 2018 | Pubmed ID: 30564571
Degradation Kinetics of Clavulanic Acid in Fermentation Broths at Low Temperatures.
Antibiotics (Basel, Switzerland) Jan, 2019 | Pubmed ID: 30658482
Carboxylic acid consumption and production by Corynebacterium glutamicum.
Biotechnology progress May, 2019 | Pubmed ID: 30851150
Antibacterial and anticancer activities of orphan biosynthetic gene clusters from Atlantis II Red Sea brine pool.
Microbial cell factories Mar, 2019 | Pubmed ID: 30885206
Reproduction of Large-Scale Bioreactor Conditions on Microfluidic Chips.
Microorganisms Apr, 2019 | Pubmed ID: 31010155
Construction and characterization of broad-host-range reporter plasmid suitable for on-line analysis of bacterial host responses related to recombinant protein production.
Microbial cell factories May, 2019 | Pubmed ID: 31064376
Monte Carlo Simulations for the Analysis of Non-linear Parameter Confidence Intervals in Optimal Experimental Design.
Frontiers in bioengineering and biotechnology , 2019 | Pubmed ID: 31179278
A UV/Vis Spectroscopy-Based Assay for Monitoring of Transformations Between Nucleosides and Nucleobases.
Methods and protocols Jul, 2019 | Pubmed ID: 31311105
A model-based framework for parallel scale-down fed-batch cultivations in mini-bioreactors for accelerated phenotyping.
Biotechnology and bioengineering Nov, 2019 | Pubmed ID: 31317526
Data of clavulanic acid and clavulanate-imidazole stability at low temperatures.
Data in brief Apr, 2019 | Pubmed ID: 31372423
Monitoring of Polyhydroxyalkanoate (PHA) Production during High-Cell-Density Plant Oil Cultivations Using Photon Density Wave Spectroscopy.
Bioengineering (Basel, Switzerland) Sep, 2019 | Pubmed ID: 31546779
Characterization of the Metabolic Response of to Shear Stress in Stirred Tanks and Single-Use 2D Rocking Motion Bioreactors for Clavulanic Acid Production.
Antibiotics (Basel, Switzerland) Sep, 2019 | Pubmed ID: 31569725
Bioprocess Development for Lantibiotic Ruminococcin-A Production in and Kinetic Insights Into LanM Enzymes Catalysis.
Frontiers in microbiology , 2019 | Pubmed ID: 31572338
Fungi as source for new bio-based materials: a patent review.
Fungal biology and biotechnology , 2019 | Pubmed ID: 31673396
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