achieving-moderate-pressures-sealed-vessels-using-dry-ice-as-solid

Achieving Moderate Pressures in Sealed Vessels Using Dry Ice As a Solid CO<sub>2</sub> Source

Herein is presented a general strategy to perform reactions under mild to moderate CO2 pressures with dry ice. This technique obviates the need for ...

University of Toledo

Elaborating amines via C-H functionalization has been an important area of research over the past decade but has generally relied on an added directing group or sterically hindered amine approach. Since free-amine-directed C(sp)-H activation is still primarily limited to cyclization reactions and to improve the sustainability and reaction scope of amine-based C-H activation, we present a strategy using CO in the form of dry ice that facilitates intermolecular C-H arylation. This methodology has been used to enable an operationally simple procedure whereby 1° and 2° aliphatic amines can be arylated selectively at their γ-C-H positions. In addition to potentially serving as a directing group, CO has also been demonstrated to curtail the oxidation of sensitive amine substrates.

Michael C. Young

Department of Chemistry and Biochemistry,
School of Green Chemistry and Engineering

University of Toledo

Achieving Moderate Pressures in Sealed Vessels Using Dry Ice As a Solid CO₂ Source

Michael C. Young

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Chemistry and Biochemistry,School of Green Chemistry and Engineering

University of Toledo

Achieving Moderate Pressures in Sealed Vessels Using Dry Ice As a Solid CO2 Source

Department of Chemistry and Biochemistry,
School of Green Chemistry and Engineering

Achieving Moderate Pressures in Sealed Vessels Using Dry Ice As a Solid CO₂ Source