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Department of Biochemistry and Genetics,
La Trobe Institute for Molecular Science,
Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science
Thanh Kha Phan has not added Biography.
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Phosphoinositide-mediated oligomerization of a defensin induces cell lysis.
eLife Apr, 2014 | Pubmed ID: 24692446
The Tomato Defensin TPP3 Binds Phosphatidylinositol (4,5)-Bisphosphate via a Conserved Dimeric Cationic Grip Conformation To Mediate Cell Lysis.
Molecular and cellular biology Jun, 2015 | Pubmed ID: 25802281
Human β-defensin 3 contains an oncolytic motif that binds PI(4,5)P2 to mediate tumour cell permeabilisation.
Oncotarget Jan, 2016 | Pubmed ID: 26657293
Convergent evolution of defensin sequence, structure and function.
Cellular and molecular life sciences : CMLS 02, 2017 | Pubmed ID: 27557668
Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin-lipid oligomeric assemblies and membrane permeabilization.
Proceedings of the National Academy of Sciences of the United States of America 10, 2016 | Pubmed ID: 27647905
Determining the contents and cell origins of apoptotic bodies by flow cytometry.
Scientific reports Oct, 2017 | Pubmed ID: 29089562
Importance of phosphoinositide binding by human β-defensin 3 for Akt-dependent cytokine induction.
Immunology and cell biology Jan, 2018 | Pubmed ID: 29359392
X-ray structure of a carpet-like antimicrobial defensin-phospholipid membrane disruption complex.
Nature communications May, 2018 | Pubmed ID: 29773800
Human β-defensin 2 kills through phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization.
Science advances Jul, 2018 | Pubmed ID: 30050988
La Trobe University
Thanh Kha Phan1,
Ivan KH Poon1,
Georgia K Atkin-Smith1
1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
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