Department of Oncology UNIL CHUV,
Ludwig Institute for Cancer Research Lausanne,
Department of Oncology UNIL CHUV, Ludwig Institute for Cancer Research Lausanne
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TIE-2 and VEGFR kinase activities drive immunosuppressive function of TIE-2-expressing monocytes in human breast tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research Jul, 2013 | Pubmed ID: 23649001
A dendritic cell vaccine pulsed with autologous hypochlorous acid-oxidized ovarian cancer lysate primes effective broad antitumor immunity: from bench to bedside.
Clinical cancer research : an official journal of the American Association for Cancer Research Sep, 2013 | Pubmed ID: 23838316
Shikonin-loaded antibody-armed nanoparticles for targeted therapy of ovarian cancer.
International journal of nanomedicine , 2014 | Pubmed ID: 24790428
Overexpression of SMARCE1 is associated with CD8+ T-cell infiltration in early stage ovarian cancer.
The international journal of biochemistry & cell biology Aug, 2014 | Pubmed ID: 24880093
Development, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer.
Oncotarget Aug, 2014 | Pubmed ID: 25051365
T cells bearing a chimeric antigen receptor against prostate-specific membrane antigen mediate vascular disruption and result in tumor regression.
Cancer immunology research Jan, 2015 | Pubmed ID: 25358763
Phage antibody display libraries: a powerful antibody discovery platform for immunotherapy.
Critical reviews in biotechnology , 2016 | Pubmed ID: 25394539
Targeting the tumor vasculature to enhance T cell activity.
Current opinion in immunology Apr, 2015 | Pubmed ID: 25665467
The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research Jun, 2015 | Pubmed ID: 25712684
Tumor-infiltrating lymphocytes in triple-negative breast cancer: a biomarker for use beyond prognosis?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Apr, 2015 | Pubmed ID: 25753438
Angiogenic activity of breast cancer patients' monocytes reverted by combined use of systems modeling and experimental approaches.
PLoS computational biology Mar, 2015 | Pubmed ID: 25768678
Multifunctional mitoxantrone-conjugated magnetic nanosystem for targeted therapy of folate receptor-overexpressing malignant cells.
Journal of nanobiotechnology Mar, 2015 | Pubmed ID: 25880772
Personalized approaches to active immunotherapy in cancer.
Biochimica et biophysica acta Jan, 2016 | Pubmed ID: 26241169
Whole Tumor Antigen Vaccines: Where Are We?
Vaccines Apr, 2015 | Pubmed ID: 26343191
Erratum to: Multifunctional mitoxantrone-conjugated magnetic nanosystem for targeted therapy of folate receptor-overexpressing malignant cells.
Journal of nanobiotechnology Sep, 2015 | Pubmed ID: 26407625
Overexpression of GPC6 and TMEM132D in Early Stage Ovarian Cancer Correlates with CD8+ T-Lymphocyte Infiltration and Increased Patient Survival.
BioMed research international , 2015 | Pubmed ID: 26448945
Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.
Cancer cell Oct, 2015 | Pubmed ID: 26461095
Targeting Programmed Cell Death 1 in Ovarian Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Dec, 2015 | Pubmed ID: 26503205
TCR-engineered T cells to treat tumors: Seeing but not touching?
Seminars in immunology Feb, 2016 | Pubmed ID: 26997556
TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer.
Oncoimmunology Feb, 2016 | Pubmed ID: 27057438
The Human Vaccines Project: A roadmap for cancer vaccine development.
Science translational medicine Apr, 2016 | Pubmed ID: 27075624
Mass spectrometry-based antigen discovery for cancer immunotherapy.
Current opinion in immunology 08, 2016 | Pubmed ID: 27155075
Ovarian cancer chemokines may not be a significant barrier during whole tumor antigen dendritic-cell vaccine and adoptive T-cell immunotherapy.
Oncoimmunology May, 2016 | Pubmed ID: 27467909
1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2).
Bioorganic & medicinal chemistry letters 09, 2016 | Pubmed ID: 27469130
Neoantigen-based cancer immunotherapy.
Annals of translational medicine Jul, 2016 | Pubmed ID: 27563649
Radiotherapy combination opportunities leveraging immunity for the next oncology practice.
CA: a cancer journal for clinicians Jan, 2017 | Pubmed ID: 27570942
Combine and Conquer: Double CTLA-4 and PD-1 Blockade Combined with Whole Tumor Antigen Vaccine Cooperate to Eradicate Tumors.
Cancer research 12, 2016 | Pubmed ID: 27909064
Human melanomas and ovarian cancers overexpressing mechanical barrier molecule genes lack immune signatures and have increased patient mortality risk.
Oncoimmunology , 2016 | Pubmed ID: 28123876
Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel.
Frontiers in immunology , 2017 | Pubmed ID: 28421069
TIE-2 expressing monocytes in human cancers.
Oncoimmunology , 2017 | Pubmed ID: 28507810
and cell-based analyses reveal strong divergence between prediction and observation of T-cell-recognized tumor antigen T-cell epitopes.
The Journal of biological chemistry 07, 2017 | Pubmed ID: 28536262
The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β-Microglobulin through Distinct Binding Sites.
Biochemistry 08, 2017 | Pubmed ID: 28671821
Identifying biological mechanisms for favorable cancer prognosis using non-hypothesis-driven iterative survival analysis.
NPJ systems biology and applications , 2016 | Pubmed ID: 28725481
Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity.
PLoS computational biology Aug, 2017 | Pubmed ID: 28832583
Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis.
Nature communications 09, 2017 | Pubmed ID: 28928446
Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy.
Oncoimmunology , 2017 | Pubmed ID: 28932632
'Hotspots' of Antigen Presentation Revealed by Human Leukocyte Antigen Ligandomics for Neoantigen Prioritization.
Frontiers in immunology , 2017 | Pubmed ID: 29104575
High-throughput and Sensitive Immunopeptidomics Platform Reveals Profound Interferonγ-Mediated Remodeling of the Human Leukocyte Antigen (HLA) Ligandome.
Molecular & cellular proteomics : MCP 03, 2018 | Pubmed ID: 29242379
Tumour endothelial marker 1/endosialin-mediated targeting of human sarcoma.
European journal of cancer (Oxford, England : 1990) 02, 2018 | Pubmed ID: 29304474
Correction to: Characterization of the first fully human anti-TEM1 scFv in models of solid tumor imaging and immunotoxin-based therapy.
Cancer immunology, immunotherapy : CII 02, 2018 | Pubmed ID: 29313073
Sensitive and frequent identification of high avidity neo-epitope specific CD8 T cells in immunotherapy-naive ovarian cancer.
Nature communications 03, 2018 | Pubmed ID: 29545564
T cell-induced CSF1 promotes melanoma resistance to PD1 blockade.
Science translational medicine 04, 2018 | Pubmed ID: 29643229
Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer.
Science translational medicine 04, 2018 | Pubmed ID: 29643231
The C-terminal extension landscape of naturally presented HLA-I ligands.
Proceedings of the National Academy of Sciences of the United States of America 05, 2018 | Pubmed ID: 29712860
Consensus guidelines for the use and interpretation of angiogenesis assays.
Angiogenesis 08, 2018 | Pubmed ID: 29766399
Label-Free Optofluidic Nanobiosensor Enables Real-Time Analysis of Single-Cell Cytokine Secretion.
Small (Weinheim an der Bergstrasse, Germany) 06, 2018 | Pubmed ID: 29806234
CART cells are prone to Fas- and DR5-mediated cell death.
Journal for immunotherapy of cancer 07, 2018 | Pubmed ID: 30005714
Estimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome.
Molecular & cellular proteomics : MCP 12, 2018 | Pubmed ID: 30171158
Correction to: CART cells are prone to Fas- and DR5-mediated cell death.
Journal for immunotherapy of cancer 09, 2018 | Pubmed ID: 30253808
Two-Dimensional Label-Free Affinity Analysis of Tumor-Specific CD8 T Cells with a Biomimetic Plasmonic Sensor.
ACS sensors 11, 2018 | Pubmed ID: 30339020
The Length Distribution and Multiple Specificity of Naturally Presented HLA-I Ligands.
Journal of immunology (Baltimore, Md. : 1950) 12, 2018 | Pubmed ID: 30429286
Addressing current challenges and future directions in immuno-oncology: expert perspectives from the 2017 NIBIT Foundation Think Tank, Siena, Italy.
Cancer immunology, immunotherapy : CII Jan, 2019 | Pubmed ID: 30564889
A severe case of refractory esophageal stenosis induced by nivolumab and responding to tocilizumab therapy.
Journal for immunotherapy of cancer 12, 2018 | Pubmed ID: 30587227
Safety and Tolerability of Adoptive Cell Therapy in Cancer.
Drug safety 02, 2019 | Pubmed ID: 30649750
Tumour-reactive T cell subsets in the microenvironment of ovarian cancer.
British journal of cancer 02, 2019 | Pubmed ID: 30718808
Tumor Landscapes: β-Catenin Drives Immune Desertification.
Clinical cancer research : an official journal of the American Association for Cancer Research May, 2019 | Pubmed ID: 30837277
The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance.
Cell stem cell 03, 2019 | Pubmed ID: 30849366
Computational KIR copy number discovery reveals interaction between inhibitory receptor burden and survival.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing , 2019 | Pubmed ID: 30864318
Correction: Tumour-reactive T cell subsets in the microenvironment of ovarian cancer.
British journal of cancer Apr, 2019 | Pubmed ID: 30890776
Going Beyond the Sequences: TCR Binding Patterns at the Service of Cancer Detection.
Cancer research 04, 2019 | Pubmed ID: 30936076
High-throughput Screening of Human Tumor Antigen-specific CD4 T Cells, Including Neoantigen-reactive T Cells.
Clinical cancer research : an official journal of the American Association for Cancer Research Jul, 2019 | Pubmed ID: 31015344
Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors.
Cancer cell Jun, 2019 | Pubmed ID: 31185212
Mass spectrometry driven exploration reveals nuances of neoepitope-driven tumor rejection.
JCI insight Jun, 2019 | Pubmed ID: 31219806
Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function.
Frontiers in immunology , 2019 | Pubmed ID: 31244820
Rational combinations of immunotherapy with radiotherapy in ovarian cancer.
The Lancet. Oncology Aug, 2019 | Pubmed ID: 31364594
A Phase Ib Study of the Combination of Personalized Autologous Dendritic Cell Vaccine, Aspirin, and Standard of Care Adjuvant Chemotherapy Followed by Nivolumab for Resected Pancreatic Adenocarcinoma-A Proof of Antigen Discovery Feasibility in Three Patients.
Frontiers in immunology , 2019 | Pubmed ID: 31440238
Integrating SpyCatcher/SpyTag covalent fusion technology into phage display workflows for rapid antibody discovery.
Scientific reports Sep, 2019 | Pubmed ID: 31492910
Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8 T cells.
Journal for immunotherapy of cancer Oct, 2019 | Pubmed ID: 31601268
Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes.
Nature biotechnology Nov, 2019 | Pubmed ID: 31611696
CD8 Binding of MHC-Peptide Complexes in cis or trans Regulates CD8 T-cell Responses.
Journal of molecular biology Dec, 2019 | Pubmed ID: 31704286
Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment.
Journal for immunotherapy of cancer Nov, 2019 | Pubmed ID: 31735170
A Phase I/II trial comparing autologous dendritic cell vaccine pulsed either with personalized peptides (PEP-DC) or with tumor lysate (OC-DC) in patients with advanced high-grade ovarian serous carcinoma.
Journal of translational medicine Nov, 2019 | Pubmed ID: 31771601
Neutrophils suppress tumor-infiltrating T cells in colon cancer via matrix metalloproteinase-mediated activation of TGFβ.
EMBO molecular medicine Dec, 2019 | Pubmed ID: 31793740
Analysis of Secondary Structure Biases in Naturally Presented HLA-I Ligands.
Frontiers in immunology , 2019 | Pubmed ID: 31824508
Mass spectrometry based immunopeptidomics leads to robust predictions of phosphorylated HLA class I ligands.
Molecular & cellular proteomics : MCP Dec, 2019 | Pubmed ID: 31848261
Mukul Girotra*,1,2,
Anne-Christine Thierry3,
Alexandre Harari1,3,
George Coukos1,
Olaia Naveiras2,4,
Nicola Vannini*,1
1Department of Oncology UNIL CHUV, Ludwig Institute for Cancer Research Lausanne, University of Lausanne,
2Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL),
3Center of Experimental Therapeutics, Department of Oncology, Centre Hospitalier Universitaire Vaudois,
4Hematology Service, Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV)
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