Stefan G. Sarafianos

Multiplex single-cell visualization of nucleic acids and protein during HIV infection.

4'-Ethynyl-2-fluoro-2'-deoxyadenosine, MK-8591: a novel HIV-1 reverse transcriptase translocation inhibitor.

Effect of tRNA on the Maturation of HIV-1 Reverse Transcriptase.

6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity.

6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H.

Antiretroviral potency of 4'-ethnyl-2'-fluoro-2'-deoxyadenosine, tenofovir alafenamide and second-generation NNRTIs across diverse HIV-1 subtypes.

Structural Implications of Genotypic Variations in HIV-1 Integrase From Diverse Subtypes.

The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase.

Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation.

Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2.

Strain-specific effect on biphasic DNA binding by HIV-1 integrase.

Novel Hepatitis B Virus Capsid-Targeting Antiviral That Aggregates Core Particles and Inhibits Nuclear Entry of Viral Cores.

CMCdG, a Novel Nucleoside Analog with Favorable Safety Features, Exerts Potent Activity against Wild-Type and Entecavir-Resistant Hepatitis B Virus.

Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker.

Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket.

Long-Acting Anti-HIV Drugs Targeting HIV-1 Reverse Transcriptase and Integrase.

Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication.

Conformational Changes in HIV-1 Reverse Transcriptase that Facilitate Its Maturation.

Determinants of Active-Site Inhibitor Interaction with HIV-1 RNase H.

Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus.

Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H.

7-Deaza-7-fluoro modification confers on 4'-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety.

Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules.

Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs.

Chemical profiling of HIV-1 capsid-targeting antiviral PF74.

Effect of P-body component Mov10 on HCV virus production and infectivity.

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.

Novel HIV-1 capsid-targeting small molecules of the PF74 binding site.