Tobias Krojer

Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.

Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6.

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.

Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects.

Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.

Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.

Ribosomal oxygenases are structurally conserved from prokaryotes to humans.

Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.

Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design.

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.

Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

An overview of heavy-atom derivatization of protein crystals.

Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.

A generic protocol for protein crystal dehydration using the HC1b humidity controller.

Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.

Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.

Gentle, fast and effective crystal soaking by acoustic dispensing.

Proper modelling of ligand binding requires an ensemble of bound and unbound states.

The XChemExplorer graphical workflow tool for routine or large-scale protein-ligand structure determination.

Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites.

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.

A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.

Achieving a Good Crystal System for Crystallographic X-Ray Fragment Screening.

A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase.

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.

Deliberately Losing Control of C-H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism.

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease.

Discovery of allosteric binding sites by crystallographic fragment screening.

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking.

The low-cost Shifter microscope stage transforms the speed and robustness of protein crystal harvesting.

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.

Structure and activation mechanism of the human liver-type glutaminase GLS2.

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.