Edgars Liepinsh

Mildronate: cardioprotective action through carnitine-lowering effect.

The methylester of gamma-butyrobetaine, but not gamma-butyrobetaine itself, induces muscarinic receptor-dependent vasodilatation.

Investigations on the pharmacology of the cardioprotective guanidine ME10092.

Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction.

Comparative pharmacological activity of optical isomers of phenibut.

Effect of inhibiting carnitine biosynthesis on male rat sexual performance.

Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart.

Quantitative analysis of phenibut in rat brain tissue extracts by liquid chromatography-tandem mass spectrometry.

Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.

Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats.

Effects of long-term mildronate treatment on cardiac and liver functions in rats.

Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism.

The anti-inflammatory and antinociceptive effects of NF-kappaB inhibitory guanidine derivative ME10092.

Mildronate exerts acute anticonvulsant and antihypnotic effects.

Flow cytometric analysis of glyoxalase-1 expression in human leukocytes.

Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats.

Mildronate treatment improves functional recovery following middle cerebral artery occlusion in rats.

Mildronate treatment alters γ-butyrobetaine and l-carnitine concentrations in healthy volunteers.

Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats.

The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine.

A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function.

The sensorimotor and cognitive deficits in rats following 90- and 120-min transient occlusion of the middle cerebral artery.

High L-carnitine concentrations do not prevent late diabetic complications in type 1 and 2 diabetic patients.

Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus.

Troubleshooting digital macro photography for image acquisition and the analysis of biological samples.

Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients.

Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion.

The heart is better protected against myocardial infarction in the fed state compared to the fasted state.

Mildronate, the inhibitor of L-carnitine transport, induces brain mitochondrial uncoupling and protects against anoxia-reoxygenation.

Magnesium nitrate attenuates blood pressure rise in SHR rats.

Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size.

Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria.

A cross-sectional survey of urinary iodine status in Latvia.

Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation.

Determination of trimethylamine-N-oxide in combination with L-carnitine and γ-butyrobetaine in human plasma by UPLC/MS/MS.

Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis.

Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella pneumoniae.

The neuroprotective effects of R-phenibut after focal cerebral ischemia.

Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance.

Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity.

Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria.

The unusual pharmacokinetics of meldonium: Implications for doping.

Response to comment by Sergei V. Jargin: "Meldonium (Mildronate): primum nоn nocere".

Carnitine and γ-Butyrobetaine Stimulate Elimination of Meldonium due to Competition for OCTN2-mediated Transport.

Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria.

Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB.

S-phenylpiracetam, a selective DAT inhibitor, reduces body weight gain without influencing locomotor activity.

Acute and long-term administration of palmitoylcarnitine induces muscle-specific insulin resistance in mice.

Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues.

Letter to the Editor: "Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris".

Mitochondrial Function in the Kidney and Heart, but Not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia.

Altered mitochondrial metabolism in the insulin-resistant heart.

Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity.

Excretion of the Polymyxin Derivative NAB739 in Murine Urine.

Cardiac metabolism as a driver and therapeutic target of myocardial infarction.

Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload.

Low-intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults.

Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice.

Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia.

Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.

Rats with congenital hydronephrosis show increased susceptibility to renal ischemia-reperfusion injury.

Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury.

Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism.

Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats.

Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage.

Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.

Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19.