Mark A. Frye

Clinical predictors of response to lamotrigine and gabapentin monotherapy in refractory affective disorders.

Principal components of the Beck Depression Inventory and regional cerebral metabolism in unipolar and bipolar depression.

Correlates of overweight and obesity in 644 patients with bipolar disorder.

Early physical and sexual abuse associated with an adverse course of bipolar illness.

High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposure.

Mania and attention deficit hyperactivity disorder in a prepubertal child: diagnostic and treatment challenges.

Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders?

Subsyndromal depression is associated with functional impairment in patients with bipolar disorder.

Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management.

Tiagabine in treatment refractory bipolar disorder: a clinical case series.

Validity of the mood disorder questionnaire: a general population study.

Acute antimanic efficacy and safety of oxcarbazepine in an open trial with an on-off-on design.

Low CSF somatostatin associated with response to nimodipine in patents with affective illness.

Odor localization requires visual feedback during free flight in Drosophila melanogaster.

Screening for bipolar disorder in the community.

Treating acute mania.

Acceleration and augmentation strategies for treating bipolar depression.

Impact of bipolar disorder on a U.S. community sample.

Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder.

Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network.

A signature of salience in the Drosophila brain.

Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method.

Impact of antidepressant discontinuation after acute bipolar depression remission on rates of depressive relapse at 1-year follow-up.

Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness.

An overview of recent findings of the Stanley Foundation Bipolar Network (Part I).

A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network.

Spatial organization of visuomotor reflexes in Drosophila.

Motor output reflects the linear superposition of visual and olfactory inputs in Drosophila.

Clinical and legal correlates of inmates with bipolar disorder at time of criminal arrest.

Unmet needs in bipolar depression.

Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network.

Chart review of the impact of attention-deficit/hyperactivity disorder comorbidity on response to lithium or divalproex sodium in adolescent mania.

Peripheral thyroid hormones and response to selective serotonin reuptake inhibitors.

Impact of depressive symptoms compared with manic symptoms in bipolar disorder: results of a U.S. community-based sample.

Closing the loop between neurobiology and flight behavior in Drosophila.

Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder.

Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial.

Reproductive function and risk for PCOS in women treated for bipolar disorder.

Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients.

Relationship between criminal arrest and community treatment history among patients with bipolar disorder.

Patterns of alcohol consumption in bipolar patients comorbid for alcohol abuse or dependence.

Longitudinal evaluation of reproductive function in women treated for bipolar disorder.

Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon.

Clinical and legal characteristics of inmates with bipolar disorder.

Use of health care services among persons who screen positive for bipolar disorder.

Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers.

Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants.

Low cerebrospinal fluid glutamate and glycine in refractory affective disorder.

Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder.

Discharge against medical advice from inpatient psychiatric treatment: a literature review.

Healthcare resource utilization in bipolar depression compared with unipolar depression: results of a United States population-based study.

Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study.

Free T4 index and clinical outcome in patients with depression.

Bipolar disorder and comorbid alcoholism: prevalence rate and treatment considerations.

New findings from the Bipolar Collaborative Network: clinical implications for therapeutics.

Incidence and time course of subsyndromal symptoms in patients with bipolar I disorder: an evaluation of 2 placebo-controlled maintenance trials.

Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trial.

Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism.

Behavioral neurobiology: a vibrating gyroscope controls fly steering maneuvers.

Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: a study using 3-Tesla proton magnetic resonance spectroscopy.

Predictors of bipolar disorder risk among patients currently treated for major depression.

Free-flight odor tracking in Drosophila is consistent with an optimal intermittent scale-free search.

Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression.

The poor prognosis of childhood-onset bipolar disorder.

Six-month prospective life charting of mood symptoms with lamotrigine monotherapy versus placebo in rapid cycling bipolar disorder.

A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders.

Lack of mania prophylaxis associated with lamotrigine monotherapy in manic-predominant bipolar I disorder.

Modal subcomponents of metabolic syndrome in patients with bipolar disorder.

A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression.

Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder.

Comorbid substance use disorder in women with bipolar disorder associated with criminal arrest.

The spatial, temporal and contrast properties of expansion and rotation flight optomotor responses in Drosophila.

Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network.

Bipolar depression: best practices for the hospitalized patient.

Defining the clinical course of bipolar disorder: response, remission, relapse, recurrence, and roughening.

Incidence of childhood-onset bipolar illness in the USA and Europe.

Crossmodal visual input for odor tracking during fly flight.

Animal behavior: flying back to front.

Are bipolar mood symptoms affected by the phase of the menstrual cycle?

Aripiprazole efficacy in irritability and disruptive-aggressive symptoms: young mania rating scale line analysis from two, randomized, double-blind, placebo-controlled trials.

Flies see second-order motion.

Context-dependent olfactory enhancement of optomotor flight control in Drosophila.

Diagnostic dilemmas and clinical correlates of mixed states in bipolar disorder.

Visual edge orientation shapes free-flight behavior in Drosophila.

Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression.

The psychometric validation of the Sheehan Disability Scale (SDS) in patients with bipolar disorder.

The neuro-ecology of resource localization in Drosophila: behavioral components of perception and search.

Invertebrate solutions for sensing gravity.

Peripheral visual circuits functionally segregate motion and phototaxis behaviors in the fly.

Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study.

Disrupting disordered neurocircuitry: treating refractory psychiatric illness with neuromodulation.

Flies require bilateral sensory input to track odor gradients in flight.

Mood stabilization and destabilization during acute and continuation phase treatment for bipolar I disorder with lamotrigine or placebo.

Olanzapine/fluoxetine combination for the treatment of mixed depression in bipolar I disorder: a post hoc analysis.

Visual stabilization dynamics are enhanced by standing flight velocity.

Neurobiology: fly gyro-vision.

Modafinil for bipolar depression with comorbid methamphetamine abuse.

Multisensory systems integration for high-performance motor control in flies.

Gender and depressive symptoms in 711 patients with bipolar disorder evaluated prospectively in the Stanley Foundation bipolar treatment outcome network.

Dynamics of optomotor responses in Drosophila to perturbations in optic flow.

Mechanisms of odor-tracking: multiple sensors for enhanced perception and behavior.

Mutation of the Drosophila vesicular GABA transporter disrupts visual figure detection.

Improving the design of maintenance studies for bipolar disorder.

Multisensory integration for odor tracking by flying Drosophila: Behavior, circuits and speculation.

Gender differences in the relationship between depressive symptoms and cravings in alcoholism.

Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood.

Adjunctive armodafinil for major depressive episodes associated with bipolar I disorder: a randomized, multicenter, double-blind, placebo-controlled, proof-of-concept study.

Prevalence and correlates of eating disorders in 875 patients with bipolar disorder.

Theta motion processing in fruit flies.

Increased suicidality in mania complicated by alcoholism.

Complexity of pharmacologic treatment required for sustained improvement in outpatients with bipolar disorder.

Utilization of residential alcoholism treatment in bipolar disorder.

Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and Germany.

Clinical practice. Bipolar disorder--a focus on depression.

Voltage-dependent mania after subthalamic nucleus deep brain stimulation in Parkinson's disease: a case report.

Pharmacogenomics of antidepressant induced mania: a review and meta-analysis of the serotonin transporter gene (5HTTLPR) association.

Odor identity influences tracking of temporally patterned plumes in Drosophila.

Direct costs of bipolar disorder versus other chronic conditions: an employer-based health plan analysis.

Review of pharmacological treatment in mood disorders and future directions for drug development.

Differences in demographic composition and in work, social, and functional limitations among the populations with unipolar depression and bipolar disorder: results from a nationally representative sample.

Trazodone and alcohol relapse: a retrospective study following residential treatment.

An olfactory circuit increases the fidelity of visual behavior.

International consensus group on depression prevention in bipolar disorder.

Valproate-induced hyperammonemic encephalopathy: an update on risk factors, clinical correlates and management.