Department of Cell Biology & Physiology
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Identification of tropoelastin as a ligand for the 65-kD FK506-binding protein, FKBP65, in the secretory pathway.
The Journal of cell biology Jan, 1998 | Pubmed ID: 9442105
Characterization of an in vitro model of elastic fiber assembly.
Molecular biology of the cell Nov, 1999 | Pubmed ID: 10564258
The microfibrillar proteins MAGP-1 and fibrillin-1 form a ternary complex with the chondroitin sulfate proteoglycan decorin.
Molecular biology of the cell May, 2000 | Pubmed ID: 10793130
Lysyl oxidase is required for vascular and diaphragmatic development in mice.
The Journal of biological chemistry Apr, 2003 | Pubmed ID: 12473682
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.
The Journal of clinical investigation Feb, 2003 | Pubmed ID: 12588882
Domains in tropoelastin that mediate elastin deposition in vitro and in vivo.
The Journal of biological chemistry May, 2003 | Pubmed ID: 12626514
A site on laminin alpha 5, AQARSAASKVKVSMKF, induces inflammatory cell production of matrix metalloproteinase-9 and chemotaxis.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2003 | Pubmed ID: 12817023
Fibrillin-1 and -2 contain heparin-binding sites important for matrix deposition and that support cell attachment.
The Biochemical journal Oct, 2003 | Pubmed ID: 12837131
Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice.
Nature medicine Aug, 2003 | Pubmed ID: 12847522
Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency.
The Journal of clinical investigation Nov, 2003 | Pubmed ID: 14597767
Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2.
The Journal of biological chemistry May, 2004 | Pubmed ID: 15044481
Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain.
The Journal of biological chemistry Jun, 2004 | Pubmed ID: 15078883
Deposition of tropoelastin into the extracellular matrix requires a competent elastic fiber scaffold but not live cells.
Matrix biology : journal of the International Society for Matrix Biology Apr, 2004 | Pubmed ID: 15172035
Vascular extracellular matrix and aortic development.
Current topics in developmental biology , 2004 | Pubmed ID: 15522742
TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome.
The Journal of clinical investigation Dec, 2004 | Pubmed ID: 15546004
Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2005 | Pubmed ID: 15710889
Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries.
American journal of physiology. Heart and circulatory physiology Sep, 2005 | Pubmed ID: 15863465
A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease.
American journal of respiratory cell and molecular biology Oct, 2005 | Pubmed ID: 16081882
Tropoelastin interacts with cell-surface glycosaminoglycans via its COOH-terminal domain.
The Journal of biological chemistry Dec, 2005 | Pubmed ID: 16192266
Elastic fiber formation: a dynamic view of extracellular matrix assembly using timer reporters.
Journal of cellular physiology Apr, 2006 | Pubmed ID: 16261592
Elastin fragments drive disease progression in a murine model of emphysema.
The Journal of clinical investigation Mar, 2006 | Pubmed ID: 16470245
Specific sequence motifs direct the oxygenation and chlorination of tryptophan by myeloperoxidase.
Biochemistry Mar, 2006 | Pubmed ID: 16548523
Chlamydomonas agglutinin is a hydroxyproline-rich glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America Oct, 1983 | Pubmed ID: 16593377
The stumbling block in lung repair of emphysema: elastic fiber assembly.
Proceedings of the American Thoracic Society Jul, 2006 | Pubmed ID: 16799087
Fibulin-5 mutations: mechanisms of impaired elastic fiber formation in recessive cutis laxa.
Human molecular genetics Dec, 2006 | Pubmed ID: 17035250
Domains 16 and 17 of tropoelastin in elastic fibre formation.
The Biochemical journal Feb, 2007 | Pubmed ID: 17037986
Elastin protein levels are a vital modifier affecting normal lung development and susceptibility to emphysema.
American journal of physiology. Lung cellular and molecular physiology Mar, 2007 | Pubmed ID: 17142349
Elastin-insufficient mice show normal cardiovascular remodeling in 2K1C hypertension despite higher baseline pressure and unique cardiovascular architecture.
American journal of physiology. Heart and circulatory physiology Jul, 2007 | Pubmed ID: 17400710
Functional rescue of elastin insufficiency in mice by the human elastin gene: implications for mouse models of human disease.
Circulation research Aug, 2007 | Pubmed ID: 17626896
The intracellular form of human MAGP1 elicits a complex and specific transcriptional response.
The international journal of biochemistry & cell biology , 2007 | Pubmed ID: 17692555
Fibulin-2 is dispensable for mouse development and elastic fiber formation.
Molecular and cellular biology Feb, 2008 | Pubmed ID: 18070922
Elastin haploinsufficiency induces alternative aging processes in the aorta.
Rejuvenation research Feb, 2008 | Pubmed ID: 18173368
Neutrophil elastase cleaves laminin-332 (laminin-5) generating peptides that are chemotactic for neutrophils.
The Journal of biological chemistry Apr, 2008 | Pubmed ID: 18178964
New insights into elastic fiber assembly.
Birth defects research. Part C, Embryo today : reviews Dec, 2007 | Pubmed ID: 18228265
Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury.
Blood Apr, 2008 | Pubmed ID: 18281502
Methods in elastic tissue biology: elastin isolation and purification.
Methods (San Diego, Calif.) May, 2008 | Pubmed ID: 18442703
Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice.
Molecular genetics and metabolism Jul, 2008 | Pubmed ID: 18479957
Modification and functional inactivation of the tropoelastin carboxy-terminal domain in cross-linked elastin.
Matrix biology : journal of the International Society for Matrix Biology Sep, 2008 | Pubmed ID: 18602002
Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems.
The Journal of biological chemistry Sep, 2008 | Pubmed ID: 18625713
Elastin insufficiency predisposes to elevated pulmonary circulatory pressures through changes in elastic artery structure.
Journal of applied physiology (Bethesda, Md. : 1985) Nov, 2008 | Pubmed ID: 18772328
Essential role for fibrillin-2 in zebrafish notochord and vascular morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists Oct, 2008 | Pubmed ID: 18816837
Fibrillins, fibulins, and matrix-associated glycoprotein modulate the kinetics and morphology of in vitro self-assembly of a recombinant elastin-like polypeptide.
Biochemistry Nov, 2008 | Pubmed ID: 18973305
Reduced vessel elasticity alters cardiovascular structure and function in newborn mice.
Circulation research May, 2009 | Pubmed ID: 19372465
Effects of chronic treatment with a low dose of nicorandil on the function of the rat aorta during ageing.
Clinical and experimental pharmacology & physiology Oct, 2009 | Pubmed ID: 19473347
Vascular extracellular matrix and arterial mechanics.
Physiological reviews Jul, 2009 | Pubmed ID: 19584318
Discrete contributions of elastic fiber components to arterial development and mechanical compliance.
Arteriosclerosis, thrombosis, and vascular biology Dec, 2009 | Pubmed ID: 19850904
Microfibril-associated glycoprotein-1, an extracellular matrix regulator of bone remodeling.
The Journal of biological chemistry Jul, 2010 | Pubmed ID: 20501659
Mechanisms of emphysema in autosomal dominant cutis laxa.
Matrix biology : journal of the International Society for Matrix Biology Sep, 2010 | Pubmed ID: 20600892
The matrix-binding domain of microfibril-associated glycoprotein-1 targets active connective tissue growth factor to a fibroblast-produced extracellular matrix.
Macromolecular bioscience Nov, 2010 | Pubmed ID: 20799254
Oxidative and nitrosative modifications of tropoelastin prevent elastic fiber assembly in vitro.
The Journal of biological chemistry Nov, 2010 | Pubmed ID: 20847053
Evidence for heterozygous abnormalities of the elastin gene (ELN) affecting the quantity of vocal fold elastic fibers: a pilot study.
Journal of voice : official journal of the Voice Foundation Mar, 2011 | Pubmed ID: 20926252
New insights into the pathogenesis of autosomal-dominant cutis laxa with report of five ELN mutations.
Human mutation Apr, 2011 | Pubmed ID: 21309044
Oxidative modifications of the C-terminal domain of tropoelastin prevent cell binding.
The Journal of biological chemistry Apr, 2011 | Pubmed ID: 21321118
Decreased aortic diameter and compliance precedes blood pressure increases in postnatal development of elastin-insufficient mice.
American journal of physiology. Heart and circulatory physiology Jul, 2011 | Pubmed ID: 21536846
Characterization of erectile function in elastin haploinsufficicent mice.
The journal of sexual medicine Nov, 2011 | Pubmed ID: 21883953
Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice.
Journal of cellular biochemistry Jan, 2012 | Pubmed ID: 21898536
Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation.
Molecular genetics and metabolism Dec, 2011 | Pubmed ID: 21944884
Genetic modifiers of cardiovascular phenotype caused by elastin haploinsufficiency act by extrinsic noncomplementation.
The Journal of biological chemistry Dec, 2011 | Pubmed ID: 22049077
Inhibition of MicroRNA-29 Enhances Elastin Levels in Cells Haploinsufficient for Elastin and in Bioengineered Vessels.
Arteriosclerosis, thrombosis, and vascular biology Nov, 2011 | Pubmed ID: 22095981
Alternative splicing and tissue-specific elastin misassembly act as biological modifiers of human elastin gene frameshift mutations associated with dominant cutis laxa.
The Journal of biological chemistry Jun, 2012 | Pubmed ID: 22573328
A fiber-based constitutive model predicts changes in amount and organization of matrix proteins with development and disease in the mouse aorta.
Biomechanics and modeling in mechanobiology Jun, 2013 | Pubmed ID: 22790326
Paxillin contracts the osteoclast cytoskeleton.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Dec, 2012 | Pubmed ID: 22807029
Overview of extracellular matrix.
Current protocols in cell biology Dec, 2012 | Pubmed ID: 23208544
Development, composition, and structural arrangements of the ciliary zonule of the mouse.
Investigative ophthalmology & visual science Apr, 2013 | Pubmed ID: 23493297
Zap70 inhibits Syk-mediated osteoclast function.
Journal of cellular biochemistry Aug, 2013 | Pubmed ID: 23494777
Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo.
The Journal of biological chemistry Oct, 2013 | Pubmed ID: 23963447
Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle.
Journal of the American Heart Association Aug, 2013 | Pubmed ID: 23974906
Ocular phenotype of Fbn2-null mice.
Investigative ophthalmology & visual science Nov, 2013 | Pubmed ID: 24130178
Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.
Investigative ophthalmology & visual science Dec, 2013 | Pubmed ID: 24265020
Altered reactivity of resistance vasculature contributes to hypertension in elastin insufficiency.
American journal of physiology. Heart and circulatory physiology Mar, 2014 | Pubmed ID: 24414067
The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-β.
Diabetes Jun, 2014 | Pubmed ID: 24458361
Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin.
American journal of respiratory cell and molecular biology Jan, 2015 | Pubmed ID: 24988442
Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.
Disease models & mechanisms May, 2015 | Pubmed ID: 25762570
The microfibril-associated glycoproteins (MAGPs) and the microfibrillar niche.
Matrix biology : journal of the International Society for Matrix Biology Sep, 2015 | Pubmed ID: 25963142
Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities.
The Journal of biological chemistry Aug, 2015 | Pubmed ID: 26178373
Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness.
American journal of physiology. Heart and circulatory physiology Sep, 2015 | Pubmed ID: 26232234
Characterization of metabolic health in mouse models of fibrillin-1 perturbation.
Matrix biology : journal of the International Society for Matrix Biology 09, 2016 | Pubmed ID: 26902431
Albumin contributes to kidney disease progression in Alport syndrome.
American journal of physiology. Renal physiology 07, 2016 | Pubmed ID: 27147675
Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans.
Proceedings of the National Academy of Sciences of the United States of America 08, 2016 | Pubmed ID: 27432961
Marrow Adipose Tissue Expansion Coincides with Insulin Resistance in MAGP1-Deficient Mice.
Frontiers in endocrinology , 2016 | Pubmed ID: 27445989
Deficient Circumferential Growth Is the Primary Determinant of Aortic Obstruction Attributable to Partial Elastin Deficiency.
Arteriosclerosis, thrombosis, and vascular biology 05, 2017 | Pubmed ID: 28254817
Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model.
Physiological reports Mar, 2017 | Pubmed ID: 28270590
Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries.
Science advances May, 2017 | Pubmed ID: 28508064
Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose-Induced Apoptosis.
Investigative ophthalmology & visual science 05, 2017 | Pubmed ID: 28538980
FGF receptors control alveolar elastogenesis.
Development (Cambridge, England) 12, 2017 | Pubmed ID: 29122839
Measurement of elastin, collagen, and total protein levels in tissues.
Methods in cell biology , 2018 | Pubmed ID: 29310774
Elastin purification and solubilization.
Methods in cell biology , 2018 | Pubmed ID: 29310779
Elastin in lung development and disease pathogenesis.
Matrix biology : journal of the International Society for Matrix Biology 11, 2018 | Pubmed ID: 29331337
Contribution of metabolic disease to bone fragility in MAGP1-deficient mice.
Matrix biology : journal of the International Society for Matrix Biology 04, 2018 | Pubmed ID: 29519758
Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease.
Matrix biology : journal of the International Society for Matrix Biology 10, 2018 | Pubmed ID: 29524629
Requisite endothelial reactivation and effective siRNA nanoparticle targeting of Etv2/Er71 in tumor angiogenesis.
JCI insight 04, 2018 | Pubmed ID: 29669933
Spatial and temporal changes in extracellular elastin and laminin distribution during lung alveolar development.
Scientific reports 05, 2018 | Pubmed ID: 29844468
Extracellular Determinants of Arterial Morphogenesis, Growth, and Homeostasis.
Current topics in developmental biology , 2018 | Pubmed ID: 29853177
Cardiovascular consequences of KATP overactivity in Cantu syndrome.
JCI insight 08, 2018 | Pubmed ID: 30089727
Decreased lysyl oxidase level protects against development of retinal vascular lesions in diabetic retinopathy.
Experimental eye research 07, 2019 | Pubmed ID: 31022398
Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress.
JCI insight 06, 2019 | Pubmed ID: 31211696
Sodium-activated potassium channels moderate excitability in vascular smooth muscle.
The Journal of physiology 10, 2019 | Pubmed ID: 31444905
Elastic fiber ultrastructure and assembly.
Matrix biology : journal of the International Society for Matrix Biology 11, 2019 | Pubmed ID: 31669522
Identification of the growth factor-binding sequence in the extracellular matrix protein MAGP-1.
The Journal of biological chemistry 02, 2020 | Pubmed ID: 31988245
Whole exome sequencing in patients with Williams-Beuren syndrome followed by disease modeling in mice points to four novel pathways that may modify stenosis risk.
Human molecular genetics May, 2020 | Pubmed ID: 32412588
A matricellular protein fibulin-4 is essential for the activation of lysyl oxidase.
Science advances Nov, 2020 | Pubmed ID: 33239290
RNA Vaccines for COVID-19: 5 Things Every Cardiologist Should Know.
JACC. Basic to translational science Dec, 2020 | Pubmed ID: 33251385
Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice.
JCI insight 03, 2021 | Pubmed ID: 33529173
SVEP1 is a human coronary artery disease locus that promotes atherosclerosis.
Science translational medicine 03, 2021 | Pubmed ID: 33762433
Inhibition of NOX1 Mitigates Blood Pressure Increases in Elastin Insufficiency.
Function (Oxford, England) , 2021 | Pubmed ID: 34223172
JNK2 Gene Silencing for Elastic Matrix Regenerative Repair.
Tissue engineering. Part A Aug, 2021 | Pubmed ID: 34409851
Tissue-specific smooth muscle cell subtypes identified by transcriptional profiling.
The international journal of biochemistry & cell biology 10, 2021 | Pubmed ID: 34411694
Vascular Smooth Muscle Cell Subpopulations and Neointimal Formation in Mouse Models of Elastin Insufficiency.
Arteriosclerosis, thrombosis, and vascular biology 12, 2021 | Pubmed ID: 34587758
Deletion of type VIII collagen reduces blood pressure, increases carotid artery functional distensibility and promotes elastin deposition.
Matrix biology plus Dec, 2021 | Pubmed ID: 34693248
Loss of Angiotensin II Type 2 Receptor Improves Blood Pressure in Elastin Insufficiency.
Frontiers in cardiovascular medicine , 2021 | Pubmed ID: 34790711
1Department of Basic Sciences, University of Health Sciences and Pharmacy,
2Department of Ophthalmology & Visual Sciences, Washington University School of Medicine,
3Department of Biomedical Engineering, The Ohio State University,
4Department of Cell Biology & Physiology, Washington University School of Medicine
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