Department of Pancreatobiliary Surgery,
The First Affiliated Hospital,
Department of Pancreatobiliary Surgery, The First Affiliated Hospital
Mrs. Liqun Huang graduated valedictorian from Wuhan University, one of the top universities in China. She has been working in various areas of pharmacology, molecular biology and microbiology. She has extensive experience with preclinical animal models of cancer, small animal surgery, pharmacology as well as cell culture, Western blot, ELISA and immunohistochemistry.
Over the years, Mrs. Huang has played an important role in the evaluation of novel anti-cancer and anti-inflammatory compounds as evidenced by several first-author publications in leading journals.
She has been a key contributor to this published work with technical excellence.
Contributions to Science
1. Evaluated phospho-sulindac as a candidate drug for the treatment of DED, studying its efficacy, safety, formulation, PK, biodistribution and mechanism of action. More work is in press and in progress.
a. Honkanen RA, Huang L, Xie G, Rigas B. Phosphosulindac is efficacious in an improved concanavalin A-based rabbit model of chronic dry eye disease. Transl Res 2018;198:58-72. PMID: 29702077. Available from: https://www.sciencedirect.com/science/article/pii/S1931524418300562?via%3Dihub
b. Wen Z, Muratomi N, Huang W, Huang L, Ren J, Yang J, Persaud Y, Loloi J, Mallangada N, Kung P, Honkanen R, Rigas B. The ocular pharmacokinetics and biodistribution of phospho-sulindac (OXT-328) formulated in nanoparticles: Enhanced and targeted tissue drug delivery. International Journal of Pharmaceutics, 2019;557:273-279. Available from:
https://www.sciencedirect.com/science/article/pii/S037851731830975X?via%3Dihub
c. Honkanen RA, Huang L, Rigas B. A rabbit model of aqueous-deficient dry eye disease induced by concanavalin A injection into the lacrimal glands: Application to drug efficacy studies. J Vis Exp; 2019; in press.
d. Honkanen RA, Huang W, Huang L, Kaplowitz K, Weissbart S, Rigas B. A new rabbit model of chronic dry eye disease induced by complete surgical dacryoadenectomy. Current Eye Research; 2019; in press.
2. Evaluated the anti-cancer properties of phospho-NSAIDs.
Phospho-NSAIDs are safe and highly effective compounds on inhibiting tumor growth in various animal models. Mrs. Huang has extensively studied their safety, efficacy and mechanism of action.
a. Huang L, Mackenzie GG, Sun Y, Ouyang N, Xie G, Vrankova K, Komninou D, Rigas B. Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds. Cancer Res. 2011 Dec 15; 71 (24):7617-27. PMCID: PMC3242900
b. Huang L, Wong CC, Cheng KW, Rigas B. Phospho-aspirin-2 (MDC-22) inhibits estrogen receptor positive breast cancer growth both in vitro and in vivo by a redox-dependent effect. PLoS One, 2014, 4;9(11):e111720. PMCID: PMC4219766
c. Huang L, Wong CC, Mackenzie GG, Sun Y, Cheng KW, Vrankova K, Alston N, Ouyang N, Rigas B. Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress. BMC Cancer. 2014 Feb 28;14:141 PMCID: PMC3941604
d. Huang L, Zhu C, Sun Y, Xie G, Mackenzie GG, Qiao G, Komninou D, Rigas B. Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: A redox/polyamine dependent effect. Carcinogenesis, 2010, 31(11): 1982-90. PMCID: PMC2966552
3. Evaluated the anti-inflammatory effects of phosphosulindac (OXT-328)
Mrs. Huang has extensively studied the anti-inflammatory and analgesic properties of OXT-328 and other structurally similar compounds in a variety of animal and cell culture models.
a. Huang L, Mackenzie G, Ouyang N, Sun Y, Xie G, Johnson F, Komniou D, Rigas B. The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats. Br J Pharmacol., 2011, 162(7):1521-33. PMCID: PMC3057290
b. Mattheolabakis G, Mackenzie GG, Huang L, Ouyang N, Cheng KW, Rigas B. Topically applied phospho-sulindac hydrogel is efficacious and safe in the treatment of experimental arthritis in rats. Pharm Res. 2013 Jun;30(6):1471-82. PMCID: PMC4395004
4. Co-developed a novel inhibitor of NF-κB activation:
Mrs. Huang was part of a team of four that developed a novel small molecule inhibitor of NF-κB based on our observation that annexin 1 is an endogenous inhibitor of NF-κB and that annexin 1 mediates the anti-inflammatory activity of all corticosteroids. This peptide is currently being developed for clinical applications.
a. Zhang Z, Huang L, Zhao W, Rigas B. Annexin 1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation: anticancer effects in vitro and in vivo. Cancer Research, 70 (6), 2379-88, 2010. PMCID: PMC2953961
5. Screening for cooperating oncogenes in leukemia:
Mrs. Huang’s early research at the National University of Singapore focused on screening for oncogenes in RUNX1+/-transgenic mice. She was involved in identifying cancer genes cooperated with the RUNX1 gene in acute myeloid leukemia (AML) by retroviral integration. The selected four publications below summarize the main points of the work.
a. Huang L, Osato M, Yanagida M, Yamashita N, Ito Y. The myeloid features of BXH2 leukemias may result from lack of one copy of repetitive sequence in the long terminal repeat (LTR) viral enhancer. International Journal of Hematology, 85(2):170-172, 2007. PMID: 17321997
b. Asou N, Yanagida M, Huang L, Yamamoto M, Shigesada K, Mitsuya H, Ito Y, Osato M. Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t(8;21)(q24;q22) acute myeloid leukemia. Blood, 109(9): 4023-4027, 2007. PMID: 17244685
c. Yamashita N, Osato M, Huang L, Yanagida M, Kogan SC, Iwasaki M, Nakamura T, Shigesada K, Asou N, Ito Y. Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice. British Journal of Hematology, 131(4): 495-507, 2005. PMID: 16281942
d. Yanagida M, Osato M, Yamashita N, Liqun H, Jacob B, Wu F, Cao X, Nakamura T, Yokomizo T, Takahashi S, Yamamoto M, Shigesada K, Ito Y. Increased dosage of RUNX1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice. Oncogene, 24(28): 4477-85, 2005. PMID: 15856017
Refractive error and visual impairment in school children in rural southern China.
Ophthalmology Feb, 2007 | Pubmed ID: 17123622
[Effect of preoperative biliary drainage on liver function changes in patients with malignant obstructive jaundice in the low bile duct before and after pancreaticoduodenectomy].
Ai zheng = Aizheng = Chinese journal of cancer Jan, 2008 | Pubmed ID: 18184470
[Determination of the postoperative effect on intestinal structure and myoelectric motility in rabbits: modified uncut jejunal loop versus Roux-en-Y biliodigestive anastomosis].
Zhonghua wai ke za zhi [Chinese journal of surgery] Jun, 2008 | Pubmed ID: 19035220
MicroRNA-143 as a tumor suppressor for bladder cancer.
The Journal of urology Mar, 2009 | Pubmed ID: 19157460
Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling.
Experimental cell research May, 2010 | Pubmed ID: 20347808
Resveratrol enhances the sensitivity of cholangiocarcinoma to chemotherapeutic agents.
Laboratory investigation; a journal of technical methods and pathology Sep, 2010 | Pubmed ID: 20458282
MicroRNA-125b suppresses the development of bladder cancer by targeting E2F3.
International journal of cancer Apr, 2011 | Pubmed ID: 20549700
13-Methyltetradecanoic acid induces mitochondrial-mediated apoptosis in human bladder cancer cells.
Urologic oncology May-Jun, 2012 | Pubmed ID: 20843711
Recent advances in the understanding of the role of the endocannabinoid system in liver diseases.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Mar, 2011 | Pubmed ID: 20934397
E13.5 retinal progenitors induce mouse bone marrow mesenchymal stromal cells to differentiate into retinal progenitor-like cells.
Cytotherapy Mar, 2011 | Pubmed ID: 20979443
Hybrid laparoscopic endoscopic single-site surgery for radical cystoprostatectomy and orthotopic ileal neobladder: an initial experience of 12 cases.
Journal of endourology Jan, 2011 | Pubmed ID: 21091222
[The epidemiological characteristic of 97,823 cases of pre-hospital medical care in Guangzhou city].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue Feb, 2011 | Pubmed ID: 21315008
Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor.
Laboratory investigation; a journal of technical methods and pathology Jul, 2011 | Pubmed ID: 21464819
Aberrant DNA methylation profile in cholangiocarcinoma.
World journal of gastrointestinal pathophysiology Jun, 2010 | Pubmed ID: 21607139
Biogenic amines serotonin and dopamine regulate cholangiocyte hyperplastic and neoplastic growth.
World journal of gastrointestinal pathophysiology Jun, 2010 | Pubmed ID: 21607143
Suppression of the HPA axis during extrahepatic biliary obstruction induces cholangiocyte proliferation in the rat.
American journal of physiology. Gastrointestinal and liver physiology Jan, 2012 | Pubmed ID: 21979757
Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism.
Gut Feb, 2012 | Pubmed ID: 22068162
Upregulation of low-density lipoprotein receptor after exposure to transforming growth factor-β2 in tenon's capsule fibroblasts from patients with glaucoma.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Apr, 2012 | Pubmed ID: 22087858
Serum starvation induced cell cycle synchronization facilitates human somatic cells reprogramming.
PloS one , 2012 | Pubmed ID: 22529890
Monoamine oxidase A expression is suppressed in human cholangiocarcinoma via coordinated epigenetic and IL-6-driven events.
Laboratory investigation; a journal of technical methods and pathology Oct, 2012 | Pubmed ID: 22906985
CRX variants in cone-rod dystrophy and mutation overview.
Biochemical and biophysical research communications Oct, 2012 | Pubmed ID: 22960069
Clinical manifestations and MRI features of vaginal endodermal sinus tumors in four children.
Pediatric radiology Aug, 2013 | Pubmed ID: 23361494
Novel GUCA1A mutation identified in a Chinese family with cone-rod dystrophy.
Neuroscience letters Apr, 2013 | Pubmed ID: 23428504
Screening for variants in 20 genes in 130 unrelated patients with cone-rod dystrophy.
Molecular medicine reports Jun, 2013 | Pubmed ID: 23563732
[Retrospective clinical analysis of 118 cases with malignant glaucoma].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology Feb, 2013 | Pubmed ID: 23714028
Exome sequencing of 47 chinese families with cone-rod dystrophy: mutations in 25 known causative genes.
PloS one , 2013 | Pubmed ID: 23776498
Systematic error of cardiac output measured by bolus thermodilution with a pulmonary artery catheter compared with that measured by an aortic flow probe in a pig model.
Journal of cardiothoracic and vascular anesthesia Dec, 2013 | Pubmed ID: 24035141
Cone-rod dysfunction is a sign of early-onset high myopia.
Optometry and vision science : official publication of the American Academy of Optometry Nov, 2013 | Pubmed ID: 24100477
LARP1 predict the prognosis for early-stage and AFP-normal hepatocellular carcinoma.
Journal of translational medicine Oct, 2013 | Pubmed ID: 24159927
Secretin stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice.
Gastroenterology Jun, 2014 | Pubmed ID: 24583060
Identification of CNGA3 mutations in 46 families: common cause of achromatopsia and cone-rod dystrophies in Chinese patients.
JAMA ophthalmology Sep, 2014 | Pubmed ID: 24903488
Regulation of the extrinsic apoptotic pathway by microRNA-21 in alcoholic liver injury.
The Journal of biological chemistry Oct, 2014 | Pubmed ID: 25118289
Arabidopsis acyl-CoA-binding protein ACBP3 participates in plant response to hypoxia by modulating very-long-chain fatty acid metabolism.
The Plant journal : for cell and molecular biology Jan, 2015 | Pubmed ID: 25284079
Serum CYFRA 21-1 in Biliary Tract Cancers: A Reliable Biomarker for Gallbladder Carcinoma and Intrahepatic Cholangiocarcinoma.
Digestive diseases and sciences May, 2015 | Pubmed ID: 25487191
Effect of asymmetric force on the condylar cartilage, subchondral bone and collagens in the temporomandibular joints.
Archives of oral biology Apr, 2015 | Pubmed ID: 25703817
Unsaturation of very-long-chain ceramides protects plant from hypoxia-induced damages by modulating ethylene signaling in Arabidopsis.
PLoS genetics Mar, 2015 | Pubmed ID: 25822663
MicroRNA-155 promotes bladder cancer growth by repressing the tumor suppressor DMTF1.
Oncotarget Apr, 2015 | Pubmed ID: 25965824
PBRM1 suppresses bladder cancer by cyclin B1 induced cell cycle arrest.
Oncotarget Apr, 2015 | Pubmed ID: 25978027
Autophagy contributes to regulation of the hypoxia response during submergence in Arabidopsis thaliana.
Autophagy , 2015 | Pubmed ID: 26566261
Molecular genetics of cone-rod dystrophy in Chinese patients: New data from 61 probands and mutation overview of 163 probands.
Experimental eye research 05, 2016 | Pubmed ID: 26992781
Molecular genetics of Leber congenital amaurosis in Chinese: New data from 66 probands and mutation overview of 159 probands.
Experimental eye research 08, 2016 | Pubmed ID: 27375279
Design, synthesis, and biological evaluation of cyclic-indole derivatives as anti-tumor agents via the inhibition of tubulin polymerization.
European journal of medicinal chemistry Jan, 2017 | Pubmed ID: 27721152
Diffusion-weighted MRI Enables to Accurately Grade Inflammatory Activity in Patients of Ileocolonic Crohn's Disease: Results from an Observational Study.
Inflammatory bowel diseases 02, 2017 | Pubmed ID: 28079618
Homozygosity Mapping and Genetic Analysis of Autosomal Recessive Retinal Dystrophies in 144 Consanguineous Pakistani Families.
Investigative ophthalmology & visual science 04, 2017 | Pubmed ID: 28418496
CXCR5-Overexpressing Mesenchymal Stromal Cells Exhibit Enhanced Homing and Can Decrease Contact Hypersensitivity.
Molecular therapy : the journal of the American Society of Gene Therapy 06, 2017 | Pubmed ID: 28454789
The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury.
The Journal of biological chemistry 07, 2017 | Pubmed ID: 28536261
Diffusion kurtosis MRI versus conventional diffusion-weighted imaging for evaluating inflammatory activity in Crohn's disease.
Journal of magnetic resonance imaging : JMRI 03, 2018 | Pubmed ID: 28577319
miR-200c Accelerates Hepatic Stellate Cell-Induced Liver Fibrosis via Targeting the FOG2/PI3K Pathway.
BioMed research international , 2017 | Pubmed ID: 28691020
An Individually Optimized Protocol of Contrast Medium Injection in Enhanced CT Scan for Liver Imaging.
Contrast media & molecular imaging , 2017 | Pubmed ID: 29097935
The Diagnostic Value of MR Imaging in Differentiating T Staging of Bladder Cancer: A Meta-Analysis.
Radiology 02, 2018 | Pubmed ID: 29206594
Characterization of Degree of Intestinal Fibrosis in Patients with Crohn Disease by Using Magnetization Transfer MR Imaging.
Radiology 05, 2018 | Pubmed ID: 29357272
T2* Mapping to characterize intestinal fibrosis in crohn's disease.
Journal of magnetic resonance imaging : JMRI Apr, 2018 | Pubmed ID: 29663577
Stanniocalcin-2 contributes to mesenchymal stromal cells attenuating murine contact hypersensitivity mainly via reducing CD8 Tc1 cells.
Cell death & disease 05, 2018 | Pubmed ID: 29748538
Knockout of microRNA-21 attenuates alcoholic hepatitis through the VHL/NF-κB signaling pathway in hepatic stellate cells.
American journal of physiology. Gastrointestinal and liver physiology 09, 2018 | Pubmed ID: 29848019
Disrupted functional connectivity within the default mode network and salience network in unmedicated bipolar II disorder.
Progress in neuro-psychopharmacology & biological psychiatry 01, 2019 | Pubmed ID: 29958116
A novel LRAT mutation affecting splicing in a family with early onset retinitis pigmentosa.
Human genomics 07, 2018 | Pubmed ID: 29973277
Autophagy regulates glucose-mediated root meristem activity by modulating ROS production in Arabidopsis.
Autophagy 03, 2019 | Pubmed ID: 30208757
COMPARISON BETWEEN RELEASABLE SCLERAL BUCKLING AND VITRECTOMY IN PATIENTS WITH PHAKIC PRIMARY RHEGMATOGENOUS RETINAL DETACHMENT.
Retina (Philadelphia, Pa.) Jan, 2020 | Pubmed ID: 30300265
Screening for autoantibodies in inflammatory neurological syndrome using fluorescence pattern in a tissue-based assay: Cerebrospinal fluid findings from 793 patients.
Multiple sclerosis and related disorders Feb, 2019 | Pubmed ID: 30611927
Disrupted Cerebellar Connectivity With the Central Executive Network and the Default-Mode Network in Unmedicated Bipolar II Disorder.
Frontiers in psychiatry , 2018 | Pubmed ID: 30618876
Controlling the Polarity of the Molecular Beam Epitaxy Grown In-Bi Atomic Film on the Si(111) Surface.
Scientific reports Jan, 2019 | Pubmed ID: 30679630
Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 Knockout Mice via Lethal-7 microRNA.
Hepatology (Baltimore, Md.) 06, 2019 | Pubmed ID: 30723922
Identification of potential diagnostic biomarkers for pneumonia caused by adenovirus infection in children by screening serum exosomal microRNAs.
Molecular medicine reports May, 2019 | Pubmed ID: 30942467
Metformin mitigates autoimmune insulitis by inhibiting Th1 and Th17 responses while promoting Treg production.
American journal of translational research , 2019 | Pubmed ID: 31105845
A novel AR translational regulator lncRNA LBCS inhibits castration resistance of prostate cancer.
Molecular cancer 06, 2019 | Pubmed ID: 31221168
Immunoglobulin-Like Transcript 5 Inhibits Macrophage-Mediated Bacterial Killing and Antigen Presentation During Sepsis.
The Journal of infectious diseases 10, 2019 | Pubmed ID: 31250008
Symmetry of folds in FEVR: A genotype-phenotype correlation study.
Experimental eye research 09, 2019 | Pubmed ID: 31299183
Abnormal resting-state regional homogeneity in unmedicated bipolar II disorder.
Journal of affective disorders 09, 2019 | Pubmed ID: 31299441
Human Mesenchymal Stem Cell-Treated Regulatory CD23CD43 B Cells Alleviate Intestinal Inflammation.
Theranostics , 2019 | Pubmed ID: 31367246
Pancreatic tumor in type 1 autoimmune pancreatitis: a diagnostic challenge.
BMC cancer Aug, 2019 | Pubmed ID: 31419961
Abnormalities of intrinsic regional brain activity in first-episode and chronic schizophrenia: a meta-analysis of resting-state functional MRI
Journal of psychiatry & neuroscience : JPN 01, 2020 | Pubmed ID: 31580042
The spectrum of genetic mutations in patients with asymptomatic mild familial exudative vitreoretinopathy.
Experimental eye research 03, 2020 | Pubmed ID: 31987760
Shear stress activates ATOH8 via autocrine VEGF promoting glycolysis dependent-survival of colorectal cancer cells in the circulation.
Journal of experimental & clinical cancer research : CR Jan, 2020 | Pubmed ID: 32000836
Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression.
Cancer letters 04, 2020 | Pubmed ID: 32014458
Analysis of Etiologic Factors in Pediatric Rhegmatogenous Retinal Detachment With Genetic Testing.
American journal of ophthalmology 10, 2020 | Pubmed ID: 32112773
Comparative analysis of retrograde intrarenal surgery and modified ultra-mini percutaneous nephrolithotomy in management of lower pole renal stones (1.5-3.5 cm).
BMC urology Mar, 2020 | Pubmed ID: 32178654
Is Hydrogen Sulfide a Concern During Treatment of Lung Adenocarcinoma With Ammonium Tetrathiomolybdate?
Frontiers in oncology , 2020 | Pubmed ID: 32195181
Data Analysis-Driven Precise Asthmatic Treatment by Targeting Mast Cells.
Endocrine, metabolic & immune disorders drug targets , 2021 | Pubmed ID: 32520694
Shared and specific patterns of dynamic functional connectivity variability of striato-cortical circuitry in unmedicated bipolar and major depressive disorders.
Psychological medicine 03, 2022 | Pubmed ID: 32648539
Inflammation is associated with decreased functional connectivity of insula in unmedicated bipolar disorder.
Brain, behavior, and immunity 10, 2020 | Pubmed ID: 32688026
Novel variants in familial exudative vitreoretinopathy patients with KIF11 mutations and the Genotype-Phenotype correlation.
Experimental eye research 10, 2020 | Pubmed ID: 32730767
Effects of transcranial magnetic stimulation on the performance of the activities of daily living and attention function after stroke: a randomized controlled trial.
Clinical rehabilitation Dec, 2020 | Pubmed ID: 32748630
Mutation Spectrum and De Novo Mutation Analysis in Stickler Syndrome Patients with High Myopia or Retinal Detachment.
Genes 08, 2020 | Pubmed ID: 32756486
Ultra-wide-field scanning laser ophthalmoscopy and optical coherence tomography in FEVR: findings and its diagnostic ability.
The British journal of ophthalmology 07, 2021 | Pubmed ID: 32788330
Characteristics of temporal dynamics of intrinsic brain activity in unmedicated bipolar disorder with suicidality.
The Australian and New Zealand journal of psychiatry 11, 2020 | Pubmed ID: 32815392
Identification of Novel Copy Number Variations of VCAN Gene in Three Chinese Families with Wagner Disease.
Genes 08, 2020 | Pubmed ID: 32854301
A novel identification system combining diffusion kurtosis imaging with conventional magnetic resonance imaging to assess intestinal strictures in patients with Crohn's disease.
Abdominal radiology (New York) 03, 2021 | Pubmed ID: 32964274
Immunotherapy for Metastatic Prostate Cancer: Current and Emerging Treatment Options.
The Urologic clinics of North America Nov, 2020 | Pubmed ID: 33008499
Common and distinct patterns of intrinsic brain activity alterations in major depression and bipolar disorder: voxel-based meta-analysis.
Translational psychiatry 10, 2020 | Pubmed ID: 33077728
Shared and specific dynamics of brain segregation and integration in bipolar disorder and major depressive disorder: A resting-state functional magnetic resonance imaging study.
Journal of affective disorders 02, 2021 | Pubmed ID: 33221713
Degree of Creeping Fat Assessed by Computed Tomography Enterography is Associated with Intestinal Fibrotic Stricture in Patients with Crohn's Disease: A Potentially Novel Mesenteric Creeping Fat Index.
Journal of Crohn's & colitis Jul, 2021 | Pubmed ID: 33411893
Clinical manifestation and genetic analysis in Chinese early onset X-linked retinoschisis.
Molecular genetics & genomic medicine 10, 2020 | Pubmed ID: 33460243
Novel Compound Heterozygous and Homozygous Variants Detected in Chinese Families with Bardet-Biedl Syndrome.
Journal of ophthalmology , 2021 | Pubmed ID: 33520300
Plasma TNFSF13B and TNFSF14 Function as Inflammatory Indicators of Severe Adenovirus Pneumonia in Pediatric Patients.
Frontiers in immunology , 2020 | Pubmed ID: 33542721
Inflammation is correlated with abnormal functional connectivity in unmedicated bipolar depression: an independent component analysis study of resting-state fMRI.
Psychological medicine Feb, 2021 | Pubmed ID: 33602352
Hepatic mosaic enhancement pattern correlates with increased inflammatory activity and adverse therapeutic outcomes in patients with Crohn's disease.
Abdominal radiology (New York) 07, 2021 | Pubmed ID: 33646351
A CT-based nomogram for predicting the malignant potential of primary gastric gastrointestinal stromal tumors preoperatively.
Abdominal radiology (New York) 07, 2021 | Pubmed ID: 33713161
The Psychological Status of General Population in Hubei Province During the COVID-19 Outbreak: A Cross-Sectional Survey Study.
Frontiers in public health , 2021 | Pubmed ID: 33968877
Large-scale network abnormality in bipolar disorder: A multimodal meta-analysis of resting-state functional and structural magnetic resonance imaging studies.
Journal of affective disorders 09, 2021 | Pubmed ID: 34087634
Diffeomorphic respiratory motion estimation of thoracoabdominal organs for image-guided interventions.
Medical physics Aug, 2021 | Pubmed ID: 34115885
Whole-Gene Deletions of Cause Familial Exudative Vitreoretinopathy.
Genes 06, 2021 | Pubmed ID: 34199009
Structural and functional brain alterations in anorexia nervosa:A multimodal meta-analysis of neuroimaging studies.
Human brain mapping 10, 2021 | Pubmed ID: 34296492
Diagnosis of Ocular Toxocariasis by Serum and Aqueous Humor IgG ELISA.
Translational vision science & technology 07, 2021 | Pubmed ID: 34323951
Psychological Effects of People Isolated in Hubei Due to COVID-19 Epidemic.
Frontiers in psychiatry , 2021 | Pubmed ID: 34393837
Native Mapping and Magnetization Transfer Imaging in Grading Bowel Fibrosis in Crohn's Disease: A Comparative Animal Study.
Biosensors Aug, 2021 | Pubmed ID: 34562892
Mortality risk factors among hospitalized children with severe pertussis.
BMC infectious diseases Oct, 2021 | Pubmed ID: 34641796
CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3.
Cell death & disease 10, 2021 | Pubmed ID: 34654797
Knobloch Syndrome Associated with Novel Variants in Chinese Population.
Genes 09, 2021 | Pubmed ID: 34680907
Versatile multi-constrained planning for thermal ablation of large liver tumors.
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society 12, 2021 | Pubmed ID: 34710628
Mydriasis-Free Flicker Electroretinograms in 204 Healthy Children Aged 0-18 Years: Reference Data From Two Cohorts.
Translational vision science & technology 11, 2021 | Pubmed ID: 34739038
Long noncoding RNA AK023096 interacts with hnRNP-K and contributes to the maintenance of self-renewal in bladder cancer stem-like cells.
Experimental cell research 12, 2021 | Pubmed ID: 34742742
A Type I Collagen-Targeted MR Imaging Probe for Staging Fibrosis in Crohn's Disease.
Frontiers in molecular biosciences , 2021 | Pubmed ID: 34859052
Choroidal Neovascularization in Pediatric Patients: Analysis of Etiologic Factors, Clinical Characteristics and Treatment Outcomes.
Frontiers in medicine , 2021 | Pubmed ID: 34912817
Impaired bone marrow microenvironment and stem cells in transfusion-dependent beta-thalassemia.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Feb, 2022 | Pubmed ID: 34923340
NONINVASIVE DIAGNOSTIC STRATEGY OF OCULAR TOXOCARIASIS BASED ON CLINICAL FEATURES.
Retina (Philadelphia, Pa.) 05, 2022 | Pubmed ID: 34923511
Common and specific patterns of functional and structural brain alterations in schizophrenia and bipolar disorder: a multimodal voxel-based meta-analysis.
Journal of psychiatry & neuroscience : JPN Jan-Feb, 2022 | Pubmed ID: 35105667
Association between resting-state functional connectivity of amygdala subregions and peripheral pro-inflammation cytokines levels in bipolar disorder.
Brain imaging and behavior Aug, 2022 | Pubmed ID: 35175549
Up-Regulated Expression of Interferon-Gamma, Interleukin-6 and Tumor Necrosis Factor-Alpha in the Endolymphatic Sac of Meniere's Disease Suggesting the Local Inflammatory Response Underlies the Mechanism of This Disease.
Frontiers in neurology , 2022 | Pubmed ID: 35280304
NDP-related retinopathies: clinical phenotype of female carriers.
The British journal of ophthalmology Mar, 2022 | Pubmed ID: 35361573
FZD4 in a Large Chinese Population With Familial Exudative Vitreoretinopathy: Molecular Characteristics and Clinical Manifestations.
Investigative ophthalmology & visual science 04, 2022 | Pubmed ID: 35394490
Thyroid hormones disturbances, cognitive deficits and abnormal dynamic functional connectivity variability of the amygdala in unmedicated bipolar disorder.
Journal of psychiatric research 06, 2022 | Pubmed ID: 35429738
Shared and specific characteristics of regional cerebral blood flow and functional connectivity in unmedicated bipolar and major depressive disorders.
Journal of affective disorders 07, 2022 | Pubmed ID: 35452757
Update on the Phenotypic and Genotypic Spectrum of -Related Retinopathy.
Genes 04, 2022 | Pubmed ID: 35456519
Deficient DNASE1L3 facilitates neutrophil extracellular traps-induced invasion via cyclic GMP-AMP synthase and the non-canonical NF-κB pathway in diabetic hepatocellular carcinoma.
Clinical & translational immunology , 2022 | Pubmed ID: 35474906
Expressional and prognostic value of HPCAL1 in cholangiocarcinoma via integrated bioinformatics analyses and experiments.
Cancer medicine May, 2022 | Pubmed ID: 35645147
Ocular manifestations of Chinese patients with copy number variants in the gene.
Molecular vision , 2022 | Pubmed ID: 35656167
Association between Incidental Pelvic Inflammation and Aggressive Prostate Cancer.
Cancers May, 2022 | Pubmed ID: 35681714
Ocular characteristics of a 6-year-Old boy with molybdenum cofactor deficiency type B.
American journal of ophthalmology case reports Sep, 2022 | Pubmed ID: 35692435
CTNND1 variants cause familial exudative vitreoretinopathy through the Wnt/cadherin axis.
JCI insight 07, 2022 | Pubmed ID: 35700046
Skills assessment after a grape-based microsurgical course for ophthalmology residents: randomised controlled trial.
The British journal of ophthalmology Jun, 2022 | Pubmed ID: 35701080
Validation of a Classification Model Using Complete Blood Count to Predict Severe Human Adenovirus Lower Respiratory Tract Infections in Pediatric Cases.
Frontiers in pediatrics , 2022 | Pubmed ID: 35712623
Multi-frequency magnetic resonance elastography of the pancreas: measurement reproducibility and variance among healthy volunteers.
Gastroenterology report , 2022 | Pubmed ID: 35910246
A prognostic survival nomogram for persons with extra-nodal natural killer-/T-cell lymphoma.
Leukemia Aug, 2022 | Pubmed ID: 35970944
Functional and structural brain abnormalities in posttraumatic stress disorder: A multimodal meta-analysis of neuroimaging studies.
Journal of psychiatric research Aug, 2022 | Pubmed ID: 36029627
ROP-like retinopathy in full/near-term newborns: A etiology, risk factors, clinical and genetic characteristics, prognosis and management.
Frontiers in medicine , 2022 | Pubmed ID: 36035399
Mesenteric abnormalities play an important role in grading intestinal fibrosis in patients with Crohn's disease: a computed tomography and clinical marker-based nomogram.
Therapeutic advances in gastroenterology , 2022 | Pubmed ID: 36090482
Functional and structural brain differences in bipolar disorder: a multimodal meta-analysis of neuroimaging studies.
Psychological medicine Sep, 2022 | Pubmed ID: 36093787
Oral Fluorescein Angiography with Ultra-Wide-Field Scanning Laser Ophthalmoscopy in Pediatric Patients Precis: Oral Fluorescein Angiography in Children.
Journal of clinical medicine Sep, 2022 | Pubmed ID: 36143067
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