Department of Pathology,
The First Affiliated Hospital,
Department of Pathology, The First Affiliated Hospital
Yuan-Na Lin is a Research Scholar in the Department of Oncology, Lombardi Cancer Center at Georgetown University School of Medicine, Washington DC. Dr. Lin is a board-certified visceral surgeon at University Hospital Hamburg-Eppendorf, Germany, where she has received her MD and Ph.D.
During her surgical residency, Dr. Lin has been working on the role of actin binding proteins in cancer cell development and metastasis in an interdisciplinary and translational approach. She has been focusing on the formins mDia1 and mDia3 in colon cancer metastasis and chromosomal instability by modulation of the cytoskeleton. She then moved to Georgetown University, Washington DC, USA, as a DFG (German Research Funding Organization) Research Scholar. Here, she set up an innovative 3D tumor spheroid co-culture platform to examine tumor cell – immune cell interactions, in order to reveal new resistance mechanisms towards T-cell mediated tumor cell killing.
As a clinician, Dr. Lin is particularly interested in bridging basic research with clinical application. Her ultimate goal is to improve immunotherapeutic treatment approaches in patients with pancreatic cancer.
Protective effects of non-mitogenic human acidic fibroblast growth factor on hydrogen peroxide-induced damage to cardiomyocytes in vitro.
World journal of gastroenterology : WJG Sep, 2005 | Pubmed ID: 16222742
Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells.
Molecular cancer , 2011 | Pubmed ID: 21592405
[Cross-sectional study of current situation of glycemic control with type 1 diabetes in Guangdong Province].
Zhonghua yi xue za zhi Dec, 2011 | Pubmed ID: 22333145
Triptolide inhibits proliferation and invasion of malignant glioma cells.
Journal of neuro-oncology Aug, 2012 | Pubmed ID: 22562416
Overexpression of RPS6KB1 predicts worse prognosis in primary HCC patients.
Medical oncology (Northwood, London, England) Dec, 2012 | Pubmed ID: 22684641
Relationship between clinical characteristics and survival of gastroenteropancreatic neuroendocrine neoplasms: A single-institution analysis (1995-2012) in South China.
BMC endocrine disorders Nov, 2012 | Pubmed ID: 23194346
Proteins related to early changes in carcinogenesis of hepatic oval cells after treatment with methylnitronitrosoguanidine.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie Mar, 2014 | Pubmed ID: 24360059
Expression of cytoskeleton regulatory protein Mena in human hepatocellular carcinoma and its prognostic significance.
Medical oncology (Northwood, London, England) May, 2014 | Pubmed ID: 24683008
Pancreatic neuroendocrine tumours: correlation between MSCT features and pathological classification.
European radiology Nov, 2014 | Pubmed ID: 25048189
Expression of O(6)-methylguanine DNA methyltransferase (MGMT) and its clinical significance in gastroenteropancreatic neuroendocrine neoplasm.
International journal of clinical and experimental pathology , 2014 | Pubmed ID: 25120800
Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2014 | Pubmed ID: 25288727
Chromogranin A as a marker for diagnosis, treatment, and survival in patients with gastroenteropancreatic neuroendocrine neoplasm.
Medicine Dec, 2014 | Pubmed ID: 25501094
Protein expression of HER2, 3, 4 in gastric cancer: correlation with clinical features and survival.
Journal of clinical pathology May, 2015 | Pubmed ID: 25731189
Transcriptional upregulation of microtubule-associated protein 2 is involved in the protein kinase A-induced decrease in the invasiveness of glioma cells.
Neuro-oncology Dec, 2015 | Pubmed ID: 26014048
Activation of Cyclic Adenosine Monophosphate Pathway Increases the Sensitivity of Cancer Cells to the Oncolytic Virus M1.
Molecular therapy : the journal of the American Society of Gene Therapy Feb, 2016 | Pubmed ID: 26373347
Granulomas as the Most Useful Histopathological Feature in Distinguishing between Crohn's Disease and Intestinal Tuberculosis in Endoscopic Biopsy Specimens.
Medicine Dec, 2015 | Pubmed ID: 26656343
Demographic and clinical characteristics of patients with type 1 diabetes mellitus: A multicenter registry study in Guangdong, China.
Journal of diabetes Nov, 2016 | Pubmed ID: 26663759
Naturally Existing Oncolytic Virus M1 Is Nonpathogenic for the Nonhuman Primates After Multiple Rounds of Repeated Intravenous Injections.
Human gene therapy 09, 2016 | Pubmed ID: 27296553
A classical PKA inhibitor increases the oncolytic effect of M1 virus via activation of exchange protein directly activated by cAMP 1.
Oncotarget Jul, 2016 | Pubmed ID: 27374176
The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes.
Cell reports 01, 2017 | Pubmed ID: 28076790
Synchronous carcinosarcoma of the uterine cervix with adenoid basal carcinoma and cervical intraepithelial neoplasia III: A case report and literature review.
Pathology, research and practice May, 2017 | Pubmed ID: 28214205
Early evaluation of sunitinib for the treatment of advanced gastroenteropancreatic neuroendocrine neoplasms via CT imaging: RECIST 1.1 or Choi Criteria?
BMC cancer 02, 2017 | Pubmed ID: 28231773
Interferon alpha antagonizes the anti-hepatoma activity of the oncolytic virus M1 by stimulating anti-viral immunity.
Oncotarget Apr, 2017 | Pubmed ID: 28445966
Somatostatin receptor expression indicates improved prognosis in gastroenteropancreatic neuroendocrine neoplasm, and octreotide long-acting release is effective and safe in Chinese patients with advanced gastroenteropancreatic neuroendocrine tumors.
Oncology letters Mar, 2017 | Pubmed ID: 28454229
Selective replication of oncolytic virus M1 results in a bystander killing effect that is potentiated by Smac mimetics.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2017 | Pubmed ID: 28607091
The role of elevated serum procalcitonin in neuroendocrine neoplasms of digestive system.
Clinical biochemistry Dec, 2017 | Pubmed ID: 28668469
Selective Antagonism of Bcl-xL Potentiates M1 Oncolysis by Enhancing Mitochondrial Apoptosis.
Human gene therapy 08, 2018 | Pubmed ID: 28750564
Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma.
Science translational medicine Aug, 2017 | Pubmed ID: 28835517
Deficiency of the IRE1α-Autophagy Axis Enhances the Antitumor Effects of the Oncolytic Virus M1.
Journal of virology 03, 2018 | Pubmed ID: 29263275
Testes-specific protease 50 (TSP50) promotes invasion and metastasis by inducing EMT in gastric cancer.
BMC cancer 01, 2018 | Pubmed ID: 29361914
Intravenous injections of the oncolytic virus M1 as a novel therapy for muscle-invasive bladder cancer.
Cell death & disease 02, 2018 | Pubmed ID: 29449555
Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus.
Nature communications 04, 2018 | Pubmed ID: 29670091
Association of Low Zinc Finger Antiviral Protein Expression with Progression and Poor Survival of Patients with Hepatocellular Carcinoma.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2018 | Pubmed ID: 30196292
Clinicopathological features and lymph node metastatic patterns of gastric mixed adenoneuroendocrine carcinoma.
Histology and histopathology Apr, 2019 | Pubmed ID: 30238962
DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage.
Nature communications 10, 2018 | Pubmed ID: 30337542
Comparison between M-score and LR-M in the reporting system of contrast-enhanced ultrasound LI-RADS.
European radiology Aug, 2019 | Pubmed ID: 30569182
DLC2 operates as a tumor suppressor gene in breast cancer via the RhoGTPase pathway.
Oncology letters Feb, 2019 | Pubmed ID: 30719106
R406 elicits anti-Warburg effect via Syk-dependent and -independent mechanisms to trigger apoptosis in glioma stem cells.
Cell death & disease 05, 2019 | Pubmed ID: 31043589
Survey and analysis of the nutritional status in hospitalized patients with malignant gastric tumors and its influence on the quality of life.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Jan, 2020 | Pubmed ID: 31049672
Negative regulation of miR-1275 by H3K27me3 is critical for glial induction of glioblastoma cells.
Molecular oncology 07, 2019 | Pubmed ID: 31162799
Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells.
Journal of experimental & clinical cancer research : CR Jun, 2019 | Pubmed ID: 31174563
Bone marrow-derived mesenchymal stem cells utilize the notch signaling pathway to induce apoptosis of hepatic stellate cells via NF-κB sensor.
Biological chemistry 03, 2020 | Pubmed ID: 31527287
Genome landscapes of rectal cancer before and after preoperative chemoradiotherapy.
Theranostics , 2019 | Pubmed ID: 31660073
Circ_0001955 facilitates hepatocellular carcinoma (HCC) tumorigenesis by sponging miR-516a-5p to release TRAF6 and MAPK11.
Cell death & disease 12, 2019 | Pubmed ID: 31822654
Preoperative prediction of tumour deposits in rectal cancer by an artificial neural network-based US radiomics model.
European radiology Apr, 2020 | Pubmed ID: 31828415
Sclerosing thymoma with extensive ossification and myasthenia gravis: an extremely rare case in the anterior mediastinum.
International journal of clinical and experimental pathology , 2017 | Pubmed ID: 31966408
Biphenotypic sinonasal sarcoma with diffuse infiltration and intracranial extension: a case report.
International journal of clinical and experimental pathology , 2017 | Pubmed ID: 31966535
The Role of Ki-67 Index Cut-off of 55% and Differentiation in Redefining NET and NEC for Grade 3 Gastrointestinal Neuroendocrine Neoplasms.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 10, 2020 | Pubmed ID: 32578023
Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancer.
Nature communications 07, 2020 | Pubmed ID: 32709844
Zinc-finger antiviral protein acts as a tumor suppressor in colorectal cancer.
Oncogene 09, 2020 | Pubmed ID: 32770142
Systematic Characterization of the Biodistribution of the Oncolytic Virus M1.
Human gene therapy 11, 2020 | Pubmed ID: 32829653
PIWI-interacting RNAs in human cancer.
Seminars in cancer biology 10, 2021 | Pubmed ID: 32877760
Development of a novel scoring system based on endoscopic appearance for management of rectal neuroendocrine tumors.
Endoscopy 07, 2021 | Pubmed ID: 32992347
Myeloid-derived suppressor cells in gastroenteropancreatic neuroendocrine neoplasms.
Endocrine 01, 2021 | Pubmed ID: 33010002
Tumors driven by RAS signaling harbor a natural vulnerability to oncolytic virus M1.
Molecular oncology 12, 2020 | Pubmed ID: 33037696
Concordance Between the Ki-67 Index Cutoff Value of 55% and Differentiation in Neuroendocrine Tumor and Neuroendocrine Carcinoma in Grade 3 Pancreatic Neuroendocrine Neoplasms.
Pancreas Nov/Dec, 2020 | Pubmed ID: 33122528
Anti-DFS70 Antibodies Among Patient and Healthy Population Cohorts in China: Results From a Multicenter Training Program Showing Spontaneous Abortion and Pediatric Systemic Autoimmune Rheumatic Diseases Are Common in Anti-DFS70 Positive Patients.
Frontiers in immunology , 2020 | Pubmed ID: 33133072
Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction.
Nature communications 11, 2020 | Pubmed ID: 33257699
Lonidamine potentiates the oncolytic efficiency of M1 virus independent of hexokinase 2 but via inhibition of antiviral immunity.
Cancer cell international Nov, 2020 | Pubmed ID: 33292203
Intravenous injection of the oncolytic virus M1 awakens antitumor T cells and overcomes resistance to checkpoint blockade.
Cell death & disease 12, 2020 | Pubmed ID: 33311488
Suppression of CCDC6 sensitizes tumor to oncolytic virus M1.
Neoplasia (New York, N.Y.) 01, 2021 | Pubmed ID: 33338804
Combining NanoKnife with M1 oncolytic virus enhances anticancer activity in pancreatic cancer.
Cancer letters 04, 2021 | Pubmed ID: 33444691
Visualization of the Oncolytic Alphavirus M1 Life Cycle in Cancer Cells.
Virologica Sinica Aug, 2021 | Pubmed ID: 33481190
Real-Time Visualization and Quantification of Oncolytic M1 Virus and .
Human gene therapy 02, 2021 | Pubmed ID: 33504253
Necroptotic virotherapy of oncolytic alphavirus M1 cooperated with Doxorubicin displays promising therapeutic efficacy in TNBC.
Oncogene 07, 2021 | Pubmed ID: 34155344
Correction to: Visualization of the Oncolytic Alphavirus M1 Life Cycle in Cancer Cells.
Virologica Sinica Aug, 2021 | Pubmed ID: 34264508
Percutaneous ethanol injection enhanced the efficacy of radiofrequency ablation in the treatment of HCC: an insight into the mechanism of ethanol action.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group , 2021 | Pubmed ID: 34542014
Oncolytic Viro-Immunotherapy: An Emerging Option in the Treatment of Gliomas.
Frontiers in immunology , 2021 | Pubmed ID: 34675919
Pituicytoma: Four cases with unusual imaging features and a literature review.
Neuro endocrinology letters Nov, 2021 | Pubmed ID: 34847317
Twin grasper-assisted endoscopic mucosa-inverting closure for large perforations after endoscopic full-thickness resection: a new endoscopic technique.
Endoscopy Dec, 2021 | Pubmed ID: 34933359
Dongjie Yang*,1,2,
Xun Hou*,1,
Wentong Lan*,3,
Minxuan Shen1,
Shaohua Yang4,
Lele Zhang1,
Qinbo Cai1,
Yan Qian1,
Yuan Lin5,
Xia Feng6,
Yulong He1,2,4
1Center for Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University,
2, Guangdong Provincial Key Laboratory of Digestive Cancer Research,
3Department of Endoscopy, The First Affiliated Hospital, Sun Yat-sen University,
4Digestive Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University,
5Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University,
6Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University
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