a-procedure-to-study-stress-induced-relapse-heroin-seeking-after

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

The punishment-imposed abstinence procedure models the self-imposed abstinence that humans initiate due to the adverse consequences associated with ...

Concordia University

Maraviroc is an antiretroviral agent and C-C chemokine coreceptor 5 (CCR5) antagonist that is currently used to treat human immunodeficiency virus. CCR5/μ-opioid receptor heterodimerization suggests that maraviroc could be a treatment for oxycodone abuse. We treated rats with maraviroc to explore its effect on oxycodone-seeking and its interference with the analgesic effects of oxycodone. We used resting-state blood-oxygen-level-dependent functional connectivity to assess the effect of maraviroc on oxycodone-enhanced coupling in the reward circuitry and performed behavioural tests to evaluate the effect of maraviroc on oxycodone rewarding properties and on oxycodone-seeking after prolonged abstinence.

Catarina Borges

Department of Psychology,
Center for Studies in Behavioral Neurobiology,
Department of Psychology, Center for Studies in Behavioral Neurobiology

Concordia University

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Catarina Borges

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Psychology,Center for Studies in Behavioral Neurobiology,Department of Psychology, Center for Studies in Behavioral Neurobiology

Concordia University

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Department of Psychology,
Center for Studies in Behavioral Neurobiology,
Department of Psychology, Center for Studies in Behavioral Neurobiology