Department of Physics,
Cancer Research UK Cambridge Institute
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Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2009 | Pubmed ID: 19903889
Imaging and 'omic' methods for the molecular diagnosis of cancer.
Expert review of molecular diagnostics May, 2010 | Pubmed ID: 20465497
Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.
Molecular cancer therapeutics Dec, 2010 | Pubmed ID: 21159611
Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy.
Magnetic resonance in medicine Aug, 2011 | Pubmed ID: 21661043
Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid: vitamin C as a probe for imaging redox status in vivo.
Journal of the American Chemical Society Aug, 2011 | Pubmed ID: 21692446
Hyperpolarized (13)C spectroscopy detects early changes in tumor vasculature and metabolism after VEGF neutralization.
Cancer research Feb, 2012 | Pubmed ID: 22223844
Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2012 | Pubmed ID: 22837393
Analysis of image heterogeneity using 2D Minkowski functionals detects tumor responses to treatment.
Magnetic resonance in medicine Jan, 2014 | Pubmed ID: 23440731
Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13) C-labeled cell metabolite and water protons.
Contrast media & molecular imaging , 2014 | Pubmed ID: 24523064
Single-pixel phase-corrected fiber bundle endomicroscopy with lensless focussing capability.
Journal of lightwave technology : a joint IEEE/OSA publication , | Pubmed ID: 27279676
Contrast agents for molecular photoacoustic imaging.
Nature methods , | Pubmed ID: 27467727
Design and validation of a near-infrared fluorescence endoscope for detection of early esophageal malignancy.
Journal of biomedical optics , | Pubmed ID: 27490221
Imaging biomarker roadmap for cancer studies.
Nature reviews. Clinical oncology Mar, 2017 | Pubmed ID: 27725679
Label-free monitoring of tissue biochemistry following traumatic brain injury using Raman spectroscopy.
The Analyst , | Pubmed ID: 27905576
Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-13C]Dehydroascorbic Acid Reduction Using 13C Magnetic Resonance Spectroscopy.
The Journal of biological chemistry , | Pubmed ID: 27994059
Evaluation of Precision in Optoacoustic Tomography for Preclinical Imaging in Living Subjects.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine May, 2017 | Pubmed ID: 28126890
Tolerancing the alignment of large-core optical fibers, fiber bundles and light guides using a Fourier approach.
Applied optics , | Pubmed ID: 28430250
Fluorescence hyperspectral imaging (fHSI) using a spectrally resolved detector array.
Journal of biophotonics , | Pubmed ID: 28485130
Photoacoustic imaging using genetically encoded reporters: a review.
Journal of biomedical optics , | Pubmed ID: 28717818
Optoacoustic Detection of Early Therapy-Induced Tumor Cell Death Using a Targeted Imaging Agent.
Clinical cancer research : an official journal of the American Association for Cancer Research , | Pubmed ID: 28821560
Oxygen Enhanced Optoacoustic Tomography (OE-OT) Reveals Vascular Dynamics in Murine Models of Prostate Cancer.
Theranostics , | Pubmed ID: 28824724
Current and Emerging Technologies for Probing Molecular Signatures of Traumatic Brain Injury.
Frontiers in neurology , | Pubmed ID: 28912750
Distance dependent photoacoustics revealed through DNA nanostructures.
Nanoscale Nov, 2017 | Pubmed ID: 29043366
Detection of early neoplasia in Barrett's esophagus using lectin-based near-infrared imaging: an ex vivo study on human tissue.
Endoscopy , | Pubmed ID: 29342490
Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species.
Royal Society open science Feb, 2018 | Pubmed ID: 29515860
Optoacoustics delineates murine breast cancer models displaying angiogenesis and vascular mimicry.
British journal of cancer , | Pubmed ID: 29576623
Emerging optical methods for endoscopic surveillance of Barrett's oesophagus.
The lancet. Gastroenterology & hepatology , | Pubmed ID: 29644977
Graphitic and oxidised high pressure high temperature (HPHT) nanodiamonds induce differential biological responses in breast cancer cell lines.
Nanoscale , | Pubmed ID: 29917033
Oxygen-Enhanced and Dynamic Contrast-Enhanced Optoacoustic Tomography Provide Surrogate Biomarkers of Tumor Vascular Function, Hypoxia, and Necrosis.
Cancer research , | Pubmed ID: 30115696
Raman micro-spectroscopy for accurate identification of primary human bronchial epithelial cells.
Scientific reports , | Pubmed ID: 30135442
An active DNA-based nanoprobe for photoacoustic pH imaging.
Chemical communications (Cambridge, England) , | Pubmed ID: 30137064
Bimodal reflectance and fluorescence multispectral endoscopy based on spectrally resolving detector arrays.
Journal of biomedical optics Oct, 2018 | Pubmed ID: 30358334
Quantitative evaluation of comb-structure correction methods for multispectral fibrescopic imaging.
Scientific reports , | Pubmed ID: 30542081
A clinically translatable hyperspectral endoscopy (HySE) system for imaging the gastrointestinal tract.
Nature communications , | Pubmed ID: 31015458
A roadmap for the clinical implementation of optical-imaging biomarkers.
Nature biomedical engineering May, 2019 | Pubmed ID: 31036890
Photoacoustic imaging as a tool to probe the tumour microenvironment.
Disease models & mechanisms , | Pubmed ID: 31337635
An Activatable Cancer-Targeted Hydrogen Peroxide Probe for Photoacoustic and Fluorescence Imaging.
Cancer research , | Pubmed ID: 31455691
Full-field quantitative phase and polarisation-resolved imaging through an optical fibre bundle.
Optics express , | Pubmed ID: 31510290
Development of a blood oxygenation phantom for photoacoustic tomography combined with online pO2 detection and flow spectrometry.
Journal of biomedical optics , | Pubmed ID: 31625321
Quantitative phase and polarization imaging through an optical fiber applied to detection of early esophageal tumorigenesis.
Journal of biomedical optics , | Pubmed ID: 31840442
Development of a blood oxygenation phantom for photoacoustic tomography combined with online pO2 detection and flow spectrometry (Erratum).
Journal of biomedical optics , | Pubmed ID: 31872581
Grayscale-to-Color: Scalable Fabrication of Custom Multispectral Filter Arrays.
ACS photonics , | Pubmed ID: 31921939
Deep learning applied to hyperspectral endoscopy for online spectral classification.
Scientific reports Mar, 2020 | Pubmed ID: 32127600
A background correction method to compensate illumination variation in hyperspectral imaging.
PloS one , | Pubmed ID: 32168335
Photoacoustics resolves species-specific differences in hemoglobin concentration and oxygenation.
Journal of biomedical optics , | Pubmed ID: 32888263
A Comparative Photophysical Study of Structural Modifications of Thioflavin T-Inspired Fluorophores.
The journal of physical chemistry letters , | Pubmed ID: 32924494
DNA-Based Nanocarriers to Enhance the Optoacoustic Contrast of Tumors In Vivo.
Advanced healthcare materials , | Pubmed ID: 33191661
Multi-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am: a targeted cell death imaging agent.
Breast cancer research : BCR , | Pubmed ID: 33596961
Correction to: Multi-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am: a targeted cell death imaging agent.
Breast cancer research : BCR , | Pubmed ID: 33722249
Learned spectral decoloring enables photoacoustic oximetry.
Scientific reports , | Pubmed ID: 33753769
Technical validation studies of a dual-wavelength LED-based photoacoustic and ultrasound imaging system.
Photoacoustics , | Pubmed ID: 33948434
Spectral Endoscopy Enhances Contrast for Neoplasia in Surveillance of Barrett's Esophagus.
Cancer research , | Pubmed ID: 34039635
First experience in clinical application of hyperspectral endoscopy for evaluation of colonic polyps.
Journal of biophotonics , | Pubmed ID: 34047490
ThX - a next-generation probe for the early detection of amyloid aggregates.
Chemical science , | Pubmed ID: 34122915
Robustness to misalignment of low-cost, compact quantitative phase imaging architectures.
OSA continuum , | Pubmed ID: 34222834
First-in-human pilot study of snapshot multispectral endoscopy for early detection of Barrett's-related neoplasia.
Journal of biomedical optics Oct, 2021 | Pubmed ID: 34628734
The IPASC data format: A consensus data format for photoacoustic imaging.
Photoacoustics , | Pubmed ID: 35287304
Opti-MSFA: a toolbox for generalized design and optimization of multispectral filter arrays.
Optics express Feb, 2022 | Pubmed ID: 35299518
The Potential of Photoacoustic Imaging in Radiation Oncology.
Frontiers in oncology , | Pubmed ID: 35311156
Evaluation of Label-Free Confocal Raman Microspectroscopy for Monitoring Oxidative Stress In Vitro in Live Human Cancer Cells.
Antioxidants (Basel, Switzerland) , | Pubmed ID: 35326223
SIMPA: an open-source toolkit for simulation and image processing for photonics and acoustics.
Journal of biomedical optics , | Pubmed ID: 35380031
Photoacoustic Tomography Detects Response and Resistance to Bevacizumab in Breast Cancer Mouse Models.
Cancer research , | Pubmed ID: 35404400
Quantification of vascular networks in photoacoustic mesoscopy.
Photoacoustics , | Pubmed ID: 35574188
Criteria for the design of tissue-mimicking phantoms for the standardization of biophotonic instrumentation.
Nature biomedical engineering , | Pubmed ID: 35624150
Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.
Journal of biomedical optics Aug, 2022 | Pubmed ID: 35922891
Photoacoustic imaging radiomics in patient-derived xenografts: a study on feature sensitivity and model discrimination.
Scientific reports Sep, 2022 | Pubmed ID: 36071117
Publisher Correction: Feasibility and sensitivity study of radiomic features in photoacoustic imaging of patient-derived xenografts.
Scientific reports Nov, 2022 | Pubmed ID: 36450766
Multispectral imaging of nailfold capillaries using light-emitting diode illumination.
Journal of biomedical optics Dec, 2022 | Pubmed ID: 36519074
Transrectal Absorber Guide Raster-Scanning Optoacoustic Mesoscopy for Label-Free In Vivo Assessment of Colitis.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) Apr, 2023 | Pubmed ID: 37083262
Performance evaluation of mesoscopic photoacoustic imaging.
Photoacoustics Jun, 2023 | Pubmed ID: 37214427
Contrast-Enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) Jun, 2023 | Pubmed ID: 37289088
Lina Hacker1,2,
Aoife M. Ivory3,
James Joseph4,5,
Janek Gröhl1,2,
Bajram Zeqiri3,
Srinath Rajagopal3,
Sarah E. Bohndiek1,2
1Department of Physics, University of Cambridge,
2Cancer Research UK Cambridge Institute, University of Cambridge,
3Ultrasound and Underwater Acoustics Group, Department of Medical, Marine and Nuclear Physics, National Physical Laboratory,
4School of Science and Engineering, University of Dundee,
5Centre for Medical Engineering and Technology, University of Dundee
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