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Department of Translational Neuroscience,
College of Human Medicine,
Department of Translational Neuroscience, College of Human Medicine
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Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.
Biochemistry Nov, 2011 | Pubmed ID: 22039833
Gene Therapy Models of Alzheimer's Disease and Other Dementias.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 26611599
Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies.
Neurobiology of disease Oct, 2016 | Pubmed ID: 27260838
Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport.
Experimental neurology Sep, 2016 | Pubmed ID: 27373205
Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition.
Neurobiology of aging 11, 2016 | Pubmed ID: 27574109
Exposure of the Amino Terminus of Tau Is a Pathological Event in Multiple Tauopathies.
The American journal of pathology Jun, 2017 | Pubmed ID: 28413156
Production of recombinant tau oligomers in vitro.
Methods in cell biology , 2017 | Pubmed ID: 28882311
Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms.
Frontiers in neuroscience , 2017 | Pubmed ID: 29089864
FTDP-17 Mutations Alter the Aggregation and Microtubule Stabilization Propensity of Tau in an Isoform-Specific Fashion.
Biochemistry Feb, 2019 | Pubmed ID: 30562452
Tau and Axonal Transport Misregulation in Tauopathies.
Advances in experimental medicine and biology , 2019 | Pubmed ID: 32096030
Liquid-liquid phase separation induces pathogenic tau conformations in vitro.
Nature communications Jun, 2020 | Pubmed ID: 32499559
Tau: A Signaling Hub Protein.
Frontiers in molecular neuroscience , 2021 | Pubmed ID: 33815057
Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2021 | Pubmed ID: 34607969
Age-dependent accumulation of tau aggregation in .
Frontiers in aging , 2022 | Pubmed ID: 36062211
Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons.
Molecular neurobiology Jun, 2023 | Pubmed ID: 36859689
Michigan State University
Rebecca L. Mueller1,2,
Nicholas M. Kanaan1,2,3,
Benjamin Combs1
1Department of Translational Neuroscience, College of Human Medicine, Michigan State University,
2Neuroscience Program, Michigan State University,
3, Hauenstein Neuroscience Center, Mercy Health Saint Mary’s
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