Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

The scaled subprofile model (SSM)1-4 is a multivariate PCA-based algorithm that identifies major sources of variation in patient and control group brain ...

The Feinstein Institute for Medical Research

To investigate the feasibility of universal newborn hearing screening in countryside in order to provide reliable evidence in launching this program all over the countryside of China.

[Study on multi-area universal newborn hearing screening in countryside of China].

D&#39;&eacute;tudier la faisabilit&eacute; du d&eacute;pistage universel d&#39;audition chez les nouveau-n&eacute;s en campagne afin de fournir des preuves fiables dans le lancement de ce programme partout dans la campagne de Chine.

[&Eacute;tude sur le d&eacute;pistage de salon multi-domaines audition chez les nouveau-n&eacute;s universelle dans la campagne de Chine].

Per studiare la fattibilit&agrave; di screening neonatale universale dell&#39;udito nella campagna al fine di fornire prove attendibili nel lancio di questo programma in tutta la campagna della Cina.

[Studio sullo screening neonatale universale-pi&ugrave; aree dell&#39;udito nella campagna di Cina].

Imaging funzionale fornisce un valore aggiunto alla valutazione clinica per valutare l&#39;efficacia delle terapie protesiche cell-based nella malattia di Parkinson (MdP).

Trapianto di cellule della dopamina nella malattia di Parkinson: sfida e prospettiva.

Functional imaging provides a valuable adjunct to clinical evaluation for assessing the efficacy of cell-based restorative therapies in Parkinson's disease (PD).

Dopamine cell transplantation in Parkinson's disease: challenge and perspective.

Imagerie fonctionnelle fournit un compl&eacute;ment pr&eacute;cieux pour l&#39;&eacute;valuation clinique pour &eacute;valuer l&#39;efficacit&eacute; des th&eacute;rapies r&eacute;paratrice cellulaire dans la maladie de Parkinson (MP).

Greffe de cellules de dopamine dans la maladie de Parkinson : d&eacute;fis et perspectives.

Parkinson's disease (PD) is associated with a characteristic regional metabolic covariance pattern that is modulated by treatment. To determine whether a homologous metabolic pattern is also present in nonhuman primate models of parkinsonism, 11 adult macaque monkeys with parkinsonism secondary to chronic systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 12 age-matched healthy animals were scanned with [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET). A subgroup comprising five parkinsonian and six control animals was used to identify a parkinsonism-related pattern (PRP). For validation, analogous topographies were derived from other subsets of parkinsonian and control animals. The PRP topography was characterized by metabolic increases in putamen/pallidum, thalamus, pons, and sensorimotor cortex, as well as reductions in the posterior parietal-occipital region. Pattern expression was significantly elevated in parkinsonian relative to healthy animals (P<0.00001). Parkinsonism-related topographies identified in the other derivation sets were very similar, with significant pairwise correlations of region weights (r>0.88; P<0.0001) and subject scores (r>0.74; P<0.01). Moreover, pattern expression in parkinsonian animals correlated with motor ratings (r>0.71; P<0.05). Thus, homologous parkinsonism-related metabolic networks are demonstrable in PD patients and in monkeys with experimental parkinsonism. Network quantification may provide a useful biomarker for the evaluation of new therapeutic agents in preclinical models of PD.

Abnormal metabolic brain networks in a nonhuman primate model of parkinsonism.

Maladie de Parkinson (MP) est associ&eacute;e &agrave; un motif caract&eacute;ristique de covariance m&eacute;taboliques r&eacute;gionaux qui est modul&eacute; par le traitement. Pour d&eacute;terminer si un profil m&eacute;tabolique homologue est &eacute;galement pr&eacute;sent dans les mod&egrave;les de primates non-humains de parkinsonisme, 11 macaques adultes avec parkinsonisme secondaire &agrave; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine syst&eacute;mique chronique (MPTP) et 12 appari&eacute;s selon l&#39;&acirc;ge des animaux sains ont &eacute;t&eacute; scann&eacute;es avec [(18) F] fluorod&eacute;soxyglucose (FDG), tomographie par &eacute;mission (TEP). Un sous-groupe comprenant cinq parkinsoniens et six animaux t&eacute;moins a &eacute;t&eacute; utilis&eacute; pour identifier un mod&egrave;le ax&eacute;es sur la maladie de Parkinson (PRP). Pour la validation, topographies analogues proviennent d&#39;autres sous-ensembles des parkinsoniens et contr&ocirc;le des animaux. La topographie de la PRP a &eacute;t&eacute; caract&eacute;ris&eacute;e par m&eacute;tabolique augmente dans le putamen/pallidum, thalamus, pons et cortex sensorimoteur, ainsi que des r&eacute;ductions dans la r&eacute;gion pari&eacute;tale-occipitale post&eacute;rieure. Expression de motif &eacute;tait significativement &eacute;lev&eacute;e chez les parkinsoniens par rapport aux animaux sains (P &lt; 0,00001). topographies Parkinsonisme li&eacute;es identifi&eacute;es dans les autres jeux de d&eacute;rivation ont &eacute;t&eacute; tr&egrave;s similaires, avec des corr&eacute;lations significatives par paires de poids de la r&eacute;gion (r &gt; 0,88 ; P &lt; 0,0001) et des scores de sujet (r &gt; 0,74 ; P &lt; 0,01). en Outre, expression de mod&egrave;le chez les parkinsoniens animaux en corr&eacute;lation avec cotes moteurs (r &gt; 0,71 ; P &lt; 0,05). Ainsi, les homologues r&eacute;seaux m&eacute;taboliques li&eacute;s &agrave; la maladie de Parkinson sont d&eacute;montrables dans les patients Parkinsoniens et chez le singe avec parkinsonisme exp&eacute;rimental. Quantification de r&eacute;seau peut fournir un biomarqueur utile pour l&#39;&eacute;valuation de nouveaux agents th&eacute;rapeutiques dans des mod&egrave;les pr&eacute;cliniques de PD.

R&eacute;seaux m&eacute;taboliques anormale du cerveau dans un mod&egrave;le de primate non humain de la maladie de Parkinson.

Malattia di Parkinson (MdP) &egrave; associata con un pattern caratteristico regionale covarianza metabolica che &egrave; modulato da un trattamento. Per determinare se &egrave; presente in modelli di primati non umani di parkinsonismo, 11 scimmie Macaco adulte con parkinsonismo anche un omologo modello metabolico secondario a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine sistemica cronica (MPTP) e 12 animali sani di et&agrave; erano scansionate con [(18) F] fluorodesossiglucosio (FDG) positron emission tomography (PET). Un sottogruppo comprendente cinque parkinsoniano e sei animali di controllo &egrave; stato utilizzato per identificare un modello di parkinsonismo-correlati (PRP). Per la convalida, topografie analoghe sono derivati da altri sottoinsiemi del parkinsoniano e controllo degli animali. La topografia PRP &egrave; stata caratterizzata da metabolica aumenta nel putamen/pallidum, talamo, pons e corteccia sensitivo-motoria, come pure riduzioni nella regione parietale-occipitale posteriore. Modello espressione era significativamente elevata in parkinsoniani rispetto gli animali sani (P &lt; 0.00001). topografie parkinsonismo-correlati identificati in altri set di derivazione erano molto simili, con significative correlazioni coppie di pesi di regione (r &amp;gt; 0,88; P &lt; 0,0001) e gol di soggetto (r &amp;gt; 0,74; P &lt; 0,01). Inoltre, espressione del modello nel parkinsoniano animali correlato con motore voti (r &amp;gt; 0,71; P &lt; 0,05). Cos&igrave;, omologhe reti metaboliche parkinsonismo-correlati sono dimostrabili in pazienti PD e nelle scimmie con parkinsonismo sperimentale. Quantificazione della rete pu&ograve; fornire un utile biomarcatore per la valutazione di nuovi agenti terapeutici in modelli preclinici di PD.

Reti di cervello metabolico anormale in un modello di primati non umani di parkinsonismo.

Regions of functional brain activation differ between novice and expert laparoscopists.

Correlation of laparoscopic experience with differential functional brain activation: a positron emission tomography study with oxygen 15-labeled water.

R&eacute;gions d&#39;activation c&eacute;r&eacute;brale fonctionnelle diff&egrave;rent entre novices et experts laparoscopists.

Corr&eacute;lation d&#39;exp&eacute;rience laparoscopique avec activation c&eacute;r&eacute;brale fonctionnelle diff&eacute;rentielle : une &eacute;tude de tomographie par &eacute;mission de positrons avec de l&#39;eau 15-&eacute;tiquet&eacute; d&#39;oxyg&egrave;ne.

Regioni di attivazione funzionale del cervello si differenziano tra principiante ed esperto laparoscopists.

Correlazione dell&#39;esperienza laparoscopica con attivazione differenziale funzionale del cervello: uno studio di tomografia ad emissione di positroni con acqua ossigeno 15-etichettati.

Tomografia ad emissione di positroni (PET) di imaging con 18 F fluorodesossiglucosio (FDG) &egrave; stata usata per identificare i modelli caratteristici del metabolismo regionale di glucosio in pazienti con di Parkinson idiopatica (IPD) e le sindromi parkinsoniane atipiche della Paralisi sopranucleare progressiva (PSP), atrofia multisistemica (MSA) multipli e sindrome cortico-basale (CBS). Abbiamo intrapreso questo studio per valutare l&#39;utilit&agrave; del fluorodesossiglucosio-PET nella diagnosi differenziale dei singoli pazienti con parkinsonismo clinico. &quot;Visual&quot; e &quot;computer-supported&quot; lettura delle scansioni PET fluorodesossiglucosio erano utilizzati per l&#39;interpretazione di immagine e confrontati con gli altri.

Diagnosi differenziale delle sindromi parkinsoniane utilizzando F-18 fluorodesossiglucosio tomografia ad emissione di positroni.

Positron emission tomography (PET) imaging with F-18 fluorodeoxyglucose (FDG) has been used to identify characteristic patterns of regional glucose metabolism in patients with idiopathic Parkinson's disease (IPD) and the atypical parkinsonian syndromes of progressive supranuclear palsy (PSP), multiple system atrophy (MSA), and corticobasal syndrome (CBS). We undertook this study to assess the utility of fluorodeoxyglucose-PET in the differential diagnosis of individual patients with clinical parkinsonism. "Visual" and "computer-supported" reading of the fluorodeoxyglucose-PET scans were used for image interpretation and compared with each other.

Differential diagnosis of parkinsonian syndromes using F-18 fluorodeoxyglucose positron emission tomography.

D&#39;&eacute;mission positons (TEP) d&#39;imagerie avec fluorod&eacute;soxyglucose (FDG), F-18 a &eacute;t&eacute; utilis&eacute; pour identifier les motifs caract&eacute;ristiques du m&eacute;tabolisme du glucose r&eacute;gionale chez les patients atteints de la maladie de Parkinson idiopathique (IPD) et les syndromes parkinsoniens atypiques de paralysie supranucl&eacute;aire progressive (PSP), multiples atrophie (MSA) et le syndrome cortico-basale (CBS). Nous avons entrepris cette &eacute;tude pour &eacute;valuer l&#39;utilit&eacute; du fluorod&eacute;soxyglucose-PET dans le diagnostic diff&eacute;rentiel des patients avec syndrome parkinsonien clinique. &laquo; Visuelle &raquo; et &quot;computer-supported&quot; lecture des scans fluorod&eacute;soxyglucose-PET ont &eacute;t&eacute; utilis&eacute;s pour l&#39;interpr&eacute;tation de l&#39;image et par rapport &agrave; l&#39;autre.

Diagnostic diff&eacute;rentiel des syndromes parkinsoniens, en utilisant la tomographie par &eacute;mission de F-18 fluorodeoxyglucose.

The therapeutic benefits of bilateral capsulotomy for the treatment of refractory obsessive compulsive disorder (OCD) are probably attributed to interruption of the cortico-striato-thalamo-cortical circuitry. We evaluated resting brain metabolism and treatment response in OCD patients using positron emission tomography (PET) imaging. [(18)F]-fluoro-deoxy-glucose PET was performed in eight OCD patients precapsulotomy and postcapsulotomy. We determined metabolic differences between preoperative images in patients and those in eight age-matched healthy volunteers, and postoperative changes and clinical correlations in the patients. The OCD patients showed widespread metabolic increases in normalized glucose metabolism in the bilateral orbitofrontal cortex and inferior frontal gyrus, cingulate gyrus, and bilateral pons/cerebellum, and metabolic decreases bilaterally in the precentral and lingual gyri. Bilateral capsulotomy resulted in significant metabolic decreases bilaterally in the prefrontal cortical regions, especially in the dorsal anterior cingulate cortex (ACC) and in the medial dorsal thalamus and caudate nucleus. In contrast, metabolism increased bilaterally in the precentral and lingual gyri. Clinical improvement in patients correlated with metabolic changes in the bilateral dorsal ACC and in the right middle occipital gyrus after capsulotomy. This study underscores the importance of the internal capsule in modulating ventral prefrontal and dorsal anterior cingulate neuronal activity in the neurosurgical management of OCD patients.

Metabolic imaging of bilateral anterior capsulotomy in refractory obsessive compulsive disorder: an FDG PET study.

Les bienfaits th&eacute;rapeutiques de la capsulotomie bilat&eacute;ral pour le traitement du r&eacute;fractaire trouble obsessionnel compulsif (TOC) sont probablement attribuables &agrave; interruption du circuit cortico-circuits striato-thalamo-cortical. Nous avons &eacute;valu&eacute; le repos r&eacute;ponse de cerveau du m&eacute;tabolisme et du traitement chez les patients TOC &agrave; l&#39;aide de l&#39;imagerie par &eacute;mission de positrons (TEP). [(18) F] - fluoro - d&eacute;soxy-glucose PET a &eacute;t&eacute; r&eacute;alis&eacute;e dans huit precapsulotomy patients TOC et postcapsulotomy. Nous avons d&eacute;termin&eacute; les diff&eacute;rences m&eacute;taboliques entre images pr&eacute;op&eacute;ratoires chez les patients et ceux de huit volontaires sains appari&eacute;s selon l&#39;&acirc;ge et les modifications postop&eacute;ratoires et corr&eacute;lations cliniques chez les patients. Les patients TOC montraient des augmentations m&eacute;taboliques g&eacute;n&eacute;ralis&eacute;es du m&eacute;tabolisme du glucose normalis&eacute;e orbitofrontal bilat&eacute;raux cortex et inf&eacute;rieure gyrus frontal, gyrus cingulaire et pons/cervelet bilat&eacute;rale, et m&eacute;tabolique diminue sur le plan bilat&eacute;ral dans les circonvolutions pr&eacute;central et linguales. Capsulotomie bilat&eacute;ral a entra&icirc;n&eacute; des diminutions significatives m&eacute;taboliques au niveau bilat&eacute;ral dans les r&eacute;gions du cortex pr&eacute;frontale, surtout dans la dorsal cortex cingulaire ant&eacute;rieur (ACC) et dans le thalamus dorsal m&eacute;dial et le noyau caud&eacute;. En revanche, le m&eacute;tabolisme augmente au niveau bilat&eacute;ral dans les circonvolutions pr&eacute;central et linguales. Am&eacute;lioration clinique chez les patients en corr&eacute;lation avec des changements m&eacute;taboliques dans l&#39;ACC dorsal bilat&eacute;ral et dans le gyrus occipital droit moyen apr&egrave;s capsulotomie. Cette &eacute;tude souligne l&#39;importance de la capsule interne dans la modulation ventrale dorsale et pr&eacute;frontale ant&eacute;rieure cingulaire activit&eacute; neuronale dans la neurochirurgie en charge des patients de trouble obsessionnel-compulsif.

Imagerie m&eacute;tabolique d&#39;une capsulotomie ant&eacute;rieure bilat&eacute;rale en r&eacute;fractaire trouble obsessionnel-compulsif : une &eacute;tude de FDG PET.

I benefici terapeutici di capsulotomia bilaterale per il trattamento del refrattario disturbo ossessivo-compulsivo (OCD) sono probabilmente attribuiti a interruzione del circuito cortico-striato-talamico-corticale. Abbiamo valutato riposa risposta cerebrale metabolismo e trattamento nei pazienti OCD mediante tomografia ad emissione di positroni (PET) imaging. [(18) F] - fluoro - deossi-glucosio PET &egrave; stata eseguita in otto precapsulotomy pazienti OCD e postcapsulotomy. Abbiamo determinato differenze metaboliche tra immagini preoperatorie in pazienti e quelli a otto volontari sani di et&agrave; corrispondente e le modifiche post-operatorie e correlazioni cliniche nei pazienti. I pazienti OCD ha mostrato diffuso aumento metabolico nel metabolismo del glucosio normalizzato nel Orbitofrontale bilaterale corteccia e inferior giro frontale, giro cingolato e pons/cervelletto bilaterale e metabolici diminuisce bilateralmente nelle circonvoluzioni precentrale e linguale. Capsulotomia bilaterale provocato significative diminuzioni metaboliche bilateralmente nelle regioni corticali prefrontale, soprattutto nella dorsale corteccia cingolata anteriore (ACC) e nel nucleo caudato e talamo dorsale mediale. Al contrario, metabolismo aumentato bilateralmente nelle circonvoluzioni precentrale e linguale. Miglioramento clinico in pazienti correlato con i cambiamenti metabolici in ACC dorsale bilaterale e la circonvoluzione occipitale destra medio dopo capsulotomia. Questo studio sottolinea l&#39;importanza della capsula interna nella modulazione ventrale prefrontale e dorsale anteriore cingolata attivit&agrave; neuronale nella gestione dei pazienti OCD neurochirurgica.

Imaging metabolico di capsulotomia anteriore bilaterale nel disturbo ossessivo-compulsivo refrattario: uno studio PET FDG.

The objective of this study was to validate Parkinson's disease-related pattern (PDRP) as a measure of network biomarker of Parkinson's disease (PD) in Chinese population by using 18F-fluorodeoxyglucose (FDG) and Positron Emission Tomography (PET). Resting-state brain FDG PET imaging was performed in a cohort of 33 PD patients and 33 age/gender-matched healthy controls to identify a PDRP. PDRP expression was then computed in a new cohort of 30 PD patients and 30 healthy controls using a voxel-based network quantification algorithm. Differences in PDRP expression were compared across groups and correlations with severities of PD were investigated. As a result, we identified a PDRP characterized by relative increases in pallidothalamic, pontine, and cerebellar metabolism, associated with concurrent metabolic decreases in the premotor and posterior parietal areas. PDRP expression in each of the two PD groups was significantly elevated relative to that of the healthy controls (P < 0.001). Receiver operating characteristic (ROC) analysis revealed that the PDRP-based discrimination for PD patients and controls had high sensitivity and specificity (both = 93.9%) in the derivation cohort, which declined slightly in the validation cohort (both = 90.0%) at the same diagnostic threshold. Moreover, PDRP scores correlated positively with Hoehn and Yahr scores (r â‰¥ 0.590, P â‰¤ 0.001) and Unified Parkinson's Disease Rating Scale motor scores (r â‰¥ 0.646, P < 0.001) in both patient groups. In conclusion, PDRP is highly reproducible in Chinese cohorts based on FDG PET imaging. Network activity of PDRP can differentiate PD patients from healthy controls and correlates with the severities of the disease.

Metabolic brain network in the Chinese patients with Parkinson's disease based on 18F-FDG PET imaging.

L&#39;objectif de cette &eacute;tude &eacute;tait de valider le mod&egrave;le ax&eacute;s sur la maladie de Parkinson (PDRP) comme mesure de biomarqueurs du r&eacute;seau de la maladie de Parkinson (PD) dans la population chinoise en utilisant le 18F-fluorod&eacute;soxyglucose (FDG) et la tomographie par &eacute;mission de positrons (TEP). L&#39;imagerie c&eacute;r&eacute;brale de l&#39;&eacute;tat de repos FDG PET s&#39;est d&eacute;roul&eacute;e dans une cohorte de patients atteints de la MP 33 et 33 t&eacute;moins sains du m&ecirc;me &acirc;ge/sexe pour identifier un PDRP. Expression PDRP &eacute;tait alors calcul&eacute;e dans une nouvelle cohorte de 30 patients Parkinsoniens et 30 t&eacute;moins sains en utilisant un algorithme de quantification du r&eacute;seau voxel. Diff&eacute;rences dans l&#39;expression PDRP ont &eacute;t&eacute; compar&eacute;s entre les groupes et les corr&eacute;lations avec les s&eacute;v&eacute;rit&eacute;s du PD ont &eacute;t&eacute; &eacute;tudi&eacute;es. Ainsi, nous avons identifi&eacute; un PDRP caract&eacute;ris&eacute;e par une augmentation relative dans pallidothalamic, pontique et m&eacute;tabolisme c&eacute;r&eacute;belleux, associ&eacute; &agrave; des diminutions m&eacute;taboliques simultan&eacute;es dans les zones pari&eacute;tales post&eacute;rieures et pr&eacute;moteur. Expression PDRP dans chacun des deux groupes PD &eacute;tait significativement &eacute;lev&eacute;e par rapport &agrave; celle des t&eacute;moins sains (P &lt; 0,001). R&eacute;cepteur op&eacute;rationnel analyse caract&eacute;ristique (ROC) a r&eacute;v&eacute;l&eacute; que la discrimination fond&eacute;e sur le PDRP pour les patients Parkinsoniens et contr&ocirc;les avait haute sensibilit&eacute; et sp&eacute;cificit&eacute; (tant = 93,9 %) dans la cohorte de d&eacute;rivation, qui a baiss&eacute; l&eacute;g&egrave;rement dans la cohorte de validation (tant = 90,0 %) au m&ecirc;me seuil diagnostique. En outre, les scores PDRP sont positivement corr&eacute;l&eacute;e avec scores Hoehn et Yahr (r &ge; 0.590, P &le; 0,001) et scores moteurs de Unified Parkinson Disease Rating Scale (r &ge; 0,646, P &lt; 0,001) dans les deux groupes de patients. En conclusion, PDRP est hautement reproductible dans les cohortes chinois bas&eacute;s sur FDG TEP. Activit&eacute; r&eacute;seau du PDRP peut diff&eacute;rencier les patients Parkinsoniens de t&eacute;moins sains et est corr&eacute;l&eacute;e avec la s&eacute;v&eacute;rit&eacute; de la maladie.

R&eacute;seau m&eacute;tabolique de cerveau chez les patients chinois avec la maladie de Parkinson bas&eacute; sur l&#39;imagerie TEP de 18F-FDG.

L&#39;obiettivo di questo studio era quello di convalidare il modello di malattia di Parkinson-correlati (PDRP) come misura di biomarker rete morbo di Parkinson (PD) nella popolazione cinese utilizzando il 18F-fluorodesossiglucosio (FDG) e tomografia a emissione di positroni (PET). Stato di riposo brain imaging PET FDG &egrave; stata eseguita in una coorte di 33 pazienti PD e 33 controlli sani et&agrave;/sesso-abbinati a identificare un PDRP. Espressione PDRP &egrave; stato quindi calcolato in una nuova coorte di 30 pazienti PD e 30 controlli sani utilizzando un algoritmo di quantificazione di voxel-based network. Le differenze nell&#39;espressione PDRP sono state confrontate tra i gruppi e le correlazioni con i livelli di gravit&agrave; del PD sono state studiate. Come risultato, abbiamo identificato un PDRP caratterizzata dal relativo aumento pallidothalamic, agro Pontino e metabolismo cerebellare, associato a concomitanti metabolici diminuisce nelle aree parietali posteriori e premotoria. Espressione PDRP in ciascuno dei due gruppi PD &egrave; stato significativamente elevato rispetto a quello dei controlli sani (P &lt; 0.001). Ricevitore opera analisi caratteristica (ROC) ha rivelato che la discriminazione basata su PDRP per i pazienti PD e controlli aveva ad alta sensibilit&agrave; e specificit&agrave; (sia = 93.9%) nella coorte di derivazione, che &egrave; diminuito leggermente nella coorte di convalida (sia = 90.0%) presso la stessa soglia diagnostica. Inoltre, punteggi PDRP correlato positivamente con gol di Hoehn e Yahr (r &ge; 0.590, P &le; 0,001) e gol di motore malattia punteggio scala Unified Parkinson (r &ge; 0.646, P &lt; 0.001) in entrambi i gruppi di pazienti. In conclusione, PDRP &egrave; altamente riproducibile in coorti cinese basati sull&#39;imaging PET FDG. Attivit&agrave; di rete di PDRP pu&ograve; differenziare i pazienti PD da controlli sani e correla con la gravit&agrave; della malattia.

Rete metabolica cerebrale nei pazienti con malattia di Parkinson basato sull&#39;imaging PET 18F-FDG cinesi.

To generate imaging biomarkers from disease-specific brain networks, we have implemented a general toolbox to rapidly perform scaled subprofile modeling (SSM) based on principal component analysis (PCA) on brain images of patients and normals. This SSMPCA toolbox can define spatial covariance patterns whose expression in individual subjects can discriminate patients from controls or predict behavioral measures. The technique may depend on differences in spatial normalization algorithms and brain imaging systems. We have evaluated the reproducibility of characteristic metabolic patterns generated by SSMPCA in patients with Parkinson's disease (PD). We used [(18) F]fluorodeoxyglucose PET scans from patients with PD and normal controls. Motor-related (PDRP) and cognition-related (PDCP) metabolic patterns were derived from images spatially normalized using four versions of SPM software (spm99, spm2, spm5, and spm8). Differences between these patterns and subject scores were compared across multiple independent groups of patients and control subjects. These patterns and subject scores were highly reproducible with different normalization programs in terms of disease discrimination and cognitive correlation. Subject scores were also comparable in patients with PD imaged across multiple PET scanners. Our findings confirm a very high degree of consistency among brain networks and their clinical correlates in PD using images normalized in four different SPM platforms. SSMPCA toolbox can be used reliably for generating disease-specific imaging biomarkers despite the continued evolution of image preprocessing software in the neuroimaging community. Network expressions can be quantified in individual patients independent of different physical characteristics of PET cameras. Hum Brain Mapp, 2013. Â© 2012 Wiley Periodicals, Inc.

Characterization of disease-related covariance topographies with SSMPCA toolbox: Effects of spatial normalization and PET scanners.

Pour g&eacute;n&eacute;rer des biomarqueurs d&#39;imagerie de r&eacute;seaux c&eacute;r&eacute;braux sp&eacute;cifiques &agrave; une maladie, nous avons impl&eacute;ment&eacute; une bo&icirc;te &agrave; outils g&eacute;n&eacute;raux pour effectuer rapidement des mod&eacute;lisation &agrave; l&#39;&eacute;chelle des sous-profils (SSM) bas&eacute;e sur l&#39;analyse en composantes principales (PCA) sur des images du cerveau des patients et normales. Cette bo&icirc;te &agrave; outils SSMPCA peut d&eacute;finir des mod&egrave;les de covariance spatiale dont l&#39;expression dans les sujets individuels peut distinguer les patients des contr&ocirc;les ou pr&eacute;dire les mesures comportementales. La technique peut d&eacute;pendre des diff&eacute;rences dans les algorithmes de normalisation spatiale et des syst&egrave;mes d&#39;imagerie c&eacute;r&eacute;brale. Nous avons &eacute;valu&eacute; la reproductibilit&eacute; des profils m&eacute;taboliques caract&eacute;ristiques g&eacute;n&eacute;r&eacute; par SSMPCA chez les patients atteints de maladie de Parkinson (MP). Nous avons utilis&eacute; [(18) F] fluorod&eacute;soxyglucose PET scans de patients atteints de PD et de contr&ocirc;les normaux. Motor-related (PDRP) et ax&eacute;es sur la cognition mod&egrave;les m&eacute;taboliques (PPPC) proviennent d&#39;images dans l&#39;espace normalis&eacute;s &agrave; l&#39;aide de quatre versions du logiciel SPM (spm99 spm2, spm5 et spm8). Diff&eacute;rences entre ces mod&egrave;les et les partitions de l&#39;objet ont &eacute;t&eacute; compar&eacute;s &agrave; travers plusieurs groupes ind&eacute;pendants des patients et des sujets t&eacute;moins. Ces patrons et les partitions de l&#39;objet ont &eacute;t&eacute; hautement reproductibles avec des programmes de normalisation diff&eacute;rents en termes de discrimination de la maladie et de corr&eacute;lation cognitive. Sujet scores &eacute;taient &eacute;galement comparables chez les patients avec PD imag&eacute; &agrave; travers de multiples tomographes TEP. Nos r&eacute;sultats confirment un tr&egrave;s haut degr&eacute; de coh&eacute;rence entre les r&eacute;seaux c&eacute;r&eacute;braux et leurs corr&eacute;lats cliniques dans PD &agrave; l&#39;aide d&#39;images normalis&eacute;es dans quatre diff&eacute;rentes plateformes SPM. Bo&icirc;te &agrave; outils SSMPCA peut &ecirc;tre utilis&eacute; avec fiabilit&eacute; pour g&eacute;n&eacute;rateurs sp&eacute;cifiques &agrave; certaines maladies biomarqueurs d&#39;imagerie malgr&eacute; l&#39;&eacute;volution continue des image logiciel dans la communaut&eacute; de neuro-imagerie de pr&eacute;traitement. Les expressions de r&eacute;seau peuvent &ecirc;tre quantifi&eacute;es dans chaque patient ind&eacute;pendant des caract&eacute;ristiques physiques diff&eacute;rentes des cam&eacute;ras de PET. Hum Brain Mapp, 2013. &copy; 2012 Wiley p&eacute;riodiques, Inc.

Caract&eacute;risation des topographies covariance li&eacute;e &agrave; la maladie avec la bo&icirc;te &agrave; outils SSMPCA : effets de normalisation spatiale et tomographes TEP.

Per generare imaging biomarkers dalle reti di malattia-specifici del cervello, abbiamo attuato una serie di strumenti generali per eseguire rapidamente la modellazione in scala subprofile (SSM), basato sull&#39;analisi delle componenti principali (PCA) sulle immagini del cervello di pazienti e normali. Questo toolbox SSMPCA possibile definire modelli di covarianza spaziale cui espressione nei singoli soggetti pu&ograve; discriminare i pazienti da controlli o prevedere misure comportamentali. La tecnica pu&ograve; dipendere da differenze nella normalizzazione spaziale algoritmi e sistemi di imaging cerebrale. Noi abbiamo valutato la riproducibilit&agrave; del caratteristico pattern metabolico generato da SSMPCA nei pazienti con malattia di Parkinson (MdP). Abbiamo usato [(18) F] fluorodesossiglucosio PET scansioni da pazienti con PD e controlli normali. Motore-correlati (PDRP) e cognizione relativi modelli metabolici (PDCP) sono stati derivati da immagini spazialmente normalizzati utilizzando quattro versioni del software SPM (spm99, spm2, spm5 e spm8). Le differenze tra questi modelli e gol di soggetto sono state confrontate attraverso molteplici gruppi indipendenti di pazienti e soggetti di controllo. Questi modelli e gol di soggetto erano altamente riproducibile con programmi di normalizzazione differenti in termini di discriminazione malattia e correlazione cognitiva. Gol di soggetto anche erano paragonabili nei pazienti con PD imaged across multiple di positroni. I nostri risultati confermano un elevato grado di coerenza tra le reti di cervello e loro clinical correlates in PD utilizzando immagini normalizzate in quattro diverse piattaforme SPM. Casella degli strumenti SSMPCA pu&ograve; essere utilizzato in modo affidabile per generare malattie specifiche imaging biomarkers nonostante la continua evoluzione del software nella Comunit&agrave; alle indagini neuroradiologiche di pre-elaborazione di immagini. Espressioni di rete possono essere quantificate in singoli pazienti indipendenti di diverse caratteristiche fisiche delle telecamere di PET. Hum cervello Mapp, 2013. &copy; 2012 Wiley periodici, Inc.

Shichun Peng

Center for Neurosciences

The Feinstein Institute for Medical Research

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Shichun Peng

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Center for Neurosciences

The Feinstein Institute for Medical Research

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Center for Neurosciences