Michele Melchiorre

Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers.

Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators.

Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers.

Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers.

Lipid markers of "geometrical" radical stress: synthesis of monotrans cholesteryl ester isomers and detection in human plasma.

Novel blockers of hyperpolarization-activated current with isoform selectivity in recombinant cells and native tissue.

Trans fatty acids: chemical synthesis of eicosapentaenoic acid isomers and detection in rats fed a deodorized fish oil diet.

Biomimetic models of radical stress and related biomarkers.

Non-enzymatic modifications in metallothioneins connected to lipid membrane damages: Structural and biomimetic studies under reductive radical stress.