Jaap A. Joles

Inducible nitric oxide synthase in renal transplantation.

Proteinuria is preceded by decreased nitric oxide synthesis and prevented by a NO donor in cholesterol-fed rats.

Anti-inflammatory effects of tetrahydrobiopterin on early rejection in renal allografts: modulation of inducible nitric oxide synthase.

Visualizing tubular lipid peroxidation in intact renal tissue in hypertensive rats.

Male gender increases sensitivity to renal injury in response to cholesterol loading.

NO dependency of RBF and autoregulation in the spontaneously hypertensive rat.

Hypoxanthine plus xanthine oxidase causes profound natriuresis without affecting renal blood flow autoregulation.

Bone-marrow-derived cells contribute to glomerular endothelial repair in experimental glomerulonephritis.

Hypoalbuminaemia enhances the renal vasoconstrictor effect of lysophosphatidylcholine.

Temporary losartan or captopril in young SHR induces malignant hypertension despite initial normotension.

Sympathetic hyperactivity in chronic renal failure: a wake-up call.

Causes and consequences of increased sympathetic activity in renal disease.

Broadly altered gene expression in blood leukocytes in essential hypertension is absent during treatment.

Hypercholesterolemia in rats induces podocyte stress and decreases renal cortical nitric oxide synthesis via an angiotensin II type 1 receptor-sensitive mechanism.

Perinatal L-arginine and antioxidant supplements reduce adult blood pressure in spontaneously hypertensive rats.

The role of nitric oxide in renal transplantation.

Programming blood pressure in adult SHR by shifting perinatal balance of NO and reactive oxygen species toward NO: the inverted Barker phenomenon.

The severe cardiorenal syndrome: 'Guyton revisited'.

Nitric oxide-dependent and nitric oxide-independent transcriptional responses to high shear stress in endothelial cells.

Resistance to oxidative stress by chronic infusion of angiotensin II in mouse kidney is not mediated by the AT2 receptor.

To D or not to D: calcitriol and vascular calcification in end-stage renal disease.

Gene expression of energy and protein metabolism in hearts of hypertensive nitric oxide- or GSH-depleted mice.

Effects of gender on hepatic HMG-CoA reductase, cholesterol 7alpha-hydroxylase, and LDL receptor in hereditary analbuminemia.

In mice, proteinuria and renal inflammatory responses to albumin overload are strain-dependent.

Tetrahydrobiopterin, but not L-arginine, decreases NO synthase uncoupling in cells expressing high levels of endothelial NO synthase.

Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in mice.

Role of circulating karyocytes in the initiation and progression of atherosclerosis.

Anti-oxidant sensitivity of donor age-related gene expression in cultured fibroblasts.

Erythropoietin and the cardiorenal syndrome: cellular mechanisms on the cardiorenal connectors.

Low albumin levels increase endothelial NO production and decrease vascular NO sensitivity.

Blood pressure in mutant rats lacking the 5-hydroxytryptamine transporter.

Transcriptome-based identification of pro- and antioxidative gene expression in kidney cortex of nitric oxide-depleted rats.

Met-RANTES reduces endothelial progenitor cell homing to activated (glomerular) endothelium in vitro and in vivo.

Protein restriction in lactation confers nephroprotective effects in the male rat and is associated with increased antioxidant expression.

Technology insight: Innovative options for end-stage renal disease--from kidney refurbishment to artificial kidney.

Maternal supplementation with citrulline increases renal nitric oxide in young spontaneously hypertensive rats and has long-term antihypertensive effects.

Mixed proximal and distal renal tubular acidosis without aminoaciduria in a mare.

Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction.

Statins and small GTPases: Koch's postulates and chronic kidney disease.

Amelioration of anti-Thy1-glomerulonephritis by PPAR-gamma agonism without increase of endothelial progenitor cell homing.

Detection of basal NO production in rat tissues using iron-dithiocarbamate complexes.

A perinatal nitric oxide donor increases renal vascular resistance and ameliorates hypertension and glomerular injury in adult fawn-hooded hypertensive rats.

CTGF inhibits BMP-7 signaling in diabetic nephropathy.

Increased expression of SOCS3 in monocytes and SOCS1 in lymphocytes correlates with progressive loss of renal function and cardiovascular risk factors in chronic kidney disease.

Increased SOCS expression in peripheral blood mononuclear cells of end stage renal disease patients is related to inflammation and dialysis modality.

Consequences of perinatal treatment with L-arginine and antioxidants for the renal transcriptome in spontaneously hypertensive rats.

Blood pressure follows the kidney: Perinatal influences on hereditary hypertension.

Taurine: red bull or red herring?

Is kidney ischemia the central mechanism in parallel activation of the renin and sympathetic system?

Renal venous congestion and renal function in congestive heart failure.

Llama heavy-chain antibody fragments efficiently remove toxic shock syndrome toxin 1 from plasma in vitro but not in experimental porcine septic shock.

Renal glutathione S-transferase mu type 1 expression is already reduced in new-born spontaneously hypertensive rats.

Renal proximal tubular dysfunction is a major determinant of urinary connective tissue growth factor excretion.

Perinatal micronutrient supplements ameliorate hypertension and proteinuria in adult fawn-hooded hypertensive rats.

Erythropoietin treatment in patients with combined heart and renal failure: objectives and design of the EPOCARES study.

Reduction of fibrosis-related arrhythmias by chronic renin-angiotensin-aldosterone system inhibitors in an aged mouse model.

IFN gamma-dependent SOCS3 expression inhibits IL-6-induced STAT3 phosphorylation and differentially affects IL-6 mediated transcriptional responses in endothelial cells.

Involvement of connective tissue growth factor in human and experimental hypertensive nephrosclerosis.

Oxidative stress in obstructive nephropathy.

Renal sinus adiposity and hypertension.

The nitric oxide donor molsidomine rescues cardiac function in rats with chronic kidney disease and cardiac dysfunction.

Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats.

Can exercise prevent preeclampsia?

Loss of endogenous bone morphogenetic protein-6 aggravates renal fibrosis.

Crossing borders: linking environmental and genetic developmental factors.

Perinatal inhibition of NF-kappaB has long-term antihypertensive effects in spontaneously hypertensive rats.

Systemic arterial and venous determinants of renal hemodynamics in congestive heart failure.

Enhanced Angiotensin II type 1 receptor expression in leukocytes of patients with chronic kidney disease.

Salt sensitivity of blood pressure: developmental and sex-related effects.

Atorvastatin reduces sympathetic activity in patients with chronic kidney disease.

Expanding the beneficial pleiotropic repertoire of interleukin-10.

Biological and technical considerations regarding the removal of bacteriotoxins in sepsis with emphasis on toxic shock syndrome toxin 1.

Subtotal nephrectomy plus coronary ligation leads to more pronounced damage in both organs than either nephrectomy or coronary ligation.

Perinatal exogenous nitric oxide in fawn-hooded hypertensive rats reduces renal ribosomal biogenesis in early life.

Effect of GFR on plasma N-terminal connective tissue growth factor (CTGF) concentrations.

A novel approach for blood purification: mixed-matrix membranes combining diffusion and adsorption in one step.

HEALTHY BONE MARROW CELLS REDUCE PROGRESSION OF KIDNEY FAILURE BETTER THAN CKD BONE MARROW CELLS IN RATS WITH ESTABLISHED CHRONIC KIDNEY DISEASE.

ACE Inhibition in Anti-Thy1 Glomerulonephritis Limits Proteinuria but Does Not Improve Renal Function and Structural Remodeling.

Human embryonic mesenchymal stem cell-derived conditioned medium rescues kidney function in rats with established chronic kidney disease.

Hypertension: Renal denervation in chronic kidney disease.

FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair.

Target organ cross talk in cardiorenal syndrome: animal models.

Short-term erythropoietin treatment does not substantially modulate monocyte transcriptomes of patients with combined heart and renal failure.

Early determinants of cardiovascular disease.

Haemodynamic influences on kidney oxygenation: clinical implications of integrative physiology.

Hemizygous deletion of CTGF/CCN2 does not suffice to prevent fibrosis of the severely injured kidney.

Healthy bone marrow cells reduce progression of kidney failure better than CKD bone marrow cells in rats with established chronic kidney disease.

The nephron number counts--from womb to tomb.

Bone marrow cell therapy in hypertensive kidney disease: contribution to cardiac fibrosis?

Ischemia and Reactive Oxygen Species in Sympathetic Hyperactivity States: A Vicious Cycle that can be Interrupted by Renal Denervation?

Can exercise partly cure the cardio-renal syndrome?

Comparative physiology and hyperuricemia as a causal factor for hypertension.