Section of Endocrinology
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Privatizing biomedical research--a 'third way'.
Nature biotechnology Jan, 2008 | Pubmed ID: 18183013
Inhibition of cardiac Na+ current by primaquine.
British journal of pharmacology Feb, 2002 | Pubmed ID: 11834623
Suppression of death receptor signaling in cerebellar Purkinje neurons protects neighboring granule neurons from apoptosis via an insulin-like growth factor I-dependent mechanism.
The Journal of biological chemistry Jul, 2002 | Pubmed ID: 11964396
Informed decision-making on sympathomimetic use in sport and health.
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine Jul, 2002 | Pubmed ID: 12131054
Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2002 | Pubmed ID: 12417654
Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells.
The Journal of biological chemistry Jun, 2003 | Pubmed ID: 12679364
A myocyte enhancer factor 2D (MEF2D) kinase activated during neuronal apoptosis is a novel target inhibited by lithium.
Journal of neurochemistry Jun, 2003 | Pubmed ID: 12787068
Inhibition of canine (NCX1.1) and Drosophila (CALX1.1) Na(+)-Ca(2+) exchangers by 7-chloro-3,5-dihydro-5-phenyl-1H-4,1-benzothiazepine-2-one (CGP-37157).
The Journal of pharmacology and experimental therapeutics Sep, 2003 | Pubmed ID: 12808003
Presence and functional significance of presynaptic ryanodine receptors.
Progress in neurobiology Apr, 2003 | Pubmed ID: 12880633
Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival.
The Journal of biological chemistry Oct, 2003 | Pubmed ID: 12896970
The pesticide rotenone induces caspase-3-mediated apoptosis in ventral mesencephalic dopaminergic neurons.
Journal of neurochemistry Nov, 2003 | Pubmed ID: 14622122
Effects of SEA0400 on mutant NCX1.1 Na+-Ca2+ exchangers with altered ionic regulation.
Molecular pharmacology Mar, 2004 | Pubmed ID: 14978259
Changes in extracellular K+ concentration modulate contractility of rat and rabbit cardiac myocytes via the inward rectifier K+ current IK1.
The Journal of physiology May, 2004 | Pubmed ID: 14990678
The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2004 | Pubmed ID: 15140920
Novel nuclear herniations induced by nuclear localization of a viral protein.
Journal of virology Jun, 2004 | Pubmed ID: 15163729
Caspase inhibition protects against reovirus-induced myocardial injury in vitro and in vivo.
Journal of virology Oct, 2004 | Pubmed ID: 15452224
Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2004 | Pubmed ID: 15525785
Frequency-dependent regulation of cardiac Na(+)/Ca(2+) exchanger.
American journal of physiology. Heart and circulatory physiology Oct, 2005 | Pubmed ID: 15951340
Distinct mechanisms of neuronal apoptosis are triggered by antagonism of Bcl-2/Bcl-x(L) versus induction of the BH3-only protein Bim.
Journal of neurochemistry Jul, 2005 | Pubmed ID: 15953346
Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons.
Journal of neurochemistry Aug, 2005 | Pubmed ID: 16092944
Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria.
The Journal of biological chemistry Oct, 2007 | Pubmed ID: 17690097
Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons.
Antioxidants & redox signaling Mar, 2009 | Pubmed ID: 18754708
Caspases indirectly regulate cleavage of the mitochondrial fusion GTPase OPA1 in neurons undergoing apoptosis.
Brain research Jan, 2009 | Pubmed ID: 19046944
KSR v. Teleflex. Part 1: Impact of U.S Supreme Court Patent Law on Canadian intellectual property and regulatory rights landscape.
Health law journal , 2007 | Pubmed ID: 19702184
KSR v. Teleflex. Part 2: Impact of U.S Supreme Court Patent Law on Canadian and global systems-based innovation ecologies.
Health law journal , 2007 | Pubmed ID: 19702185
CREB downregulation in vascular disease: a common response to cardiovascular risk.
Arteriosclerosis, thrombosis, and vascular biology Apr, 2010 | Pubmed ID: 20150559
Calpain plays a central role in 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in cerebellar granule neurons.
Neurotoxicity research Apr, 2011 | Pubmed ID: 20333497
Canada's laws on pharmaceutical intellectual property: the case for fundamental reform.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Mar, 2012 | Pubmed ID: 22065362
Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity.
The Journal of biological chemistry May, 2012 | Pubmed ID: 22378792
Neuroprotective actions of glucagon-like peptide-1 in differentiated human neuroprogenitor cells.
Journal of neurochemistry Dec, 2012 | Pubmed ID: 23020846
N-terminal cleavage of the mitochondrial fusion GTPase OPA1 occurs via a caspase-independent mechanism in cerebellar granule neurons exposed to oxidative or nitrosative stress.
Brain research Feb, 2013 | Pubmed ID: 23220553
C-terminal binding proteins are essential pro-survival factors that undergo caspase-dependent downregulation during neuronal apoptosis.
Molecular and cellular neurosciences Jul, 2013 | Pubmed ID: 23859824
Induction of an Inflammatory Loop by Interleukin-1β and Tumor Necrosis Factor-α Involves NF-kB and STAT-1 in Differentiated Human Neuroprogenitor Cells.
PloS one , 2013 | Pubmed ID: 23922745
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