Joshua D. Nosanchuk

Histoplasma capsulatum synthesizes melanin-like pigments in vitro and during mammalian infection.

Melanization of Cryptococcus neoformans and Histoplasma capsulatum reduces their susceptibilities to amphotericin B and caspofungin.

The contribution of melanin to microbial pathogenesis.

Melanin and fungi.

Synthesis of melanin-like pigments by Sporothrix schenckii in vitro and during mammalian infection.

Budding of melanized Cryptococcus neoformans in the presence or absence of L-dopa.

Experimental murine cryptococcal infection results in contamination of bedding with Cryptococcus neoformans.

Cryptococcus neoformans virulence is enhanced after growth in the genetically malleable host Dictyostelium discoideum.

'Ready made' virulence and 'dual use' virulence factors in pathogenic environmental fungi--the Cryptococcus neoformans paradigm.

Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum.

Susceptibility of the human pathogenic fungi Cryptococcus neoformans and Histoplasma capsulatum to gamma-radiation versus radioimmunotherapy with alpha- and beta-emitting radioisotopes.

Tuberculosis in New York city: recent lessons and a look ahead.

Effects of voriconazole on Cryptococcus neoformans.

Interaction of Blastomyces dermatitidis, Sporothrix schenckii, and Histoplasma capsulatum with Acanthamoeba castellanii.

Blastomyces dermatitidis produces melanin in vitro and during infection.

Dead cells in melanoma tumors provide abundant antigen for targeted delivery of ionizing radiation by a mAb to melanin.

Investigation of fungal deterioration of synthetic paint binders using vibrational spectroscopic techniques.

Microstructure of cell wall-associated melanin in the human pathogenic fungus Cryptococcus neoformans.

Melanization of Cryptococcus neoformans affects lung inflammatory responses during cryptococcal infection.

Synthesis of melanin pigment by Candida albicans in vitro and during infection.

Dual infections with pigmented and albino strains of Cryptococcus neoformans in patients with or without human immunodeficiency virus infection in India.

Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection.

Comparative analysis of Cryptococcus neoformans acid-resistant particles generated from pigmented cells grown in different laccase substrates.

Adrenal infections.

Radiolabeled melanin-binding peptides are safe and effective in treatment of human pigmented melanoma in a mouse model of disease.

Effects of disrupting the polyketide synthase gene WdPKS1 in Wangiella [Exophiala] dermatitidis on melanin production and resistance to killing by antifungal compounds, enzymatic degradation, and extremes in temperature.

Efficacy of voriconazole in experimental Cryptococcus neoformans infection.

Impact of melanin on microbial virulence and clinical resistance to antimicrobial compounds.

Synthetic consolidants attacked by melanin-producing fungi: case study of the biodeterioration of Milan (Italy) cathedral marble treated with acrylics.

Coccidioides posadasii produces melanin in vitro and during infection.

Use of mycelial-phase Sporothrix schenckii exoantigens in an enzyme-linked immunosorbent assay for diagnosis of sporotrichosis by antibody detection.

Virulence of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis in reconstituted human tissue models.

Ionizing radiation changes the electronic properties of melanin and enhances the growth of melanized fungi.

Immunoglobulins G, M, and A against Sporothrix schenckii exoantigens in patients with sporotrichosis before and during treatment with itraconazole.

Lipase 8 affects the pathogenesis of Candida albicans.

Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection.

Targeted gene deletion in Candida parapsilosis demonstrates the role of secreted lipase in virulence.

Caspofungin reduces the incidence of fungal contamination in cell culture.

Phage display library derived peptides that bind to human tumor melanin as potential vehicles for targeted radionuclide therapy of metastatic melanoma.

Voriconazole inhibits melanization in Cryptococcus neoformans.

Extracellular vesicles produced by Cryptococcus neoformans contain protein components associated with virulence.

Current status and future of antifungal therapy for systemic mycoses.

The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum.

Methamphetamine inhibits antigen processing, presentation, and phagocytosis.

Vesicular transport in Histoplasma capsulatum: an effective mechanism for trans-cell wall transfer of proteins and lipids in ascomycetes.

The radioprotective properties of fungal melanin are a function of its chemical composition, stable radical presence and spatial arrangement.

A monoclonal antibody to Histoplasma capsulatum alters the intracellular fate of the fungus in murine macrophages.

Histoplasma capsulatum at the host-pathogen interface.

Melanin as a virulence factor of Paracoccidioides brasiliensis and other dimorphic pathogenic fungi: a minireview.

Candida parapsilosis, an emerging fungal pathogen.

A role for vesicular transport of macromolecules across cell walls in fungal pathogenesis.

Monoclonal antibodies to heat shock protein 60 alter the pathogenesis of Histoplasma capsulatum.

Iatrogenic meningitis in an obstetric patient after combined spinal-epidural analgesia: case report and review of the literature.

Radioimmunotherapy of experimental human metastatic melanoma with melanin-binding antibodies and in combination with dacarbazine.

Vesicular transport across the fungal cell wall.

Growth conditions influence melanization of Brazilian clinical Sporothrix schenckii isolates.

Antimicrobial and healing efficacy of sustained release nitric oxide nanoparticles against Staphylococcus aureus skin infection.

Methamphetamine enhances histoplasmosis by immunosuppression of the host.

Acetylsalicylic acid (aspirin) reduces damage to reconstituted human tissues infected with Candida species by inhibiting extracellular fungal lipases.

The use of chitosan to damage Cryptococcus neoformans biofilms.

Nitric oxide releasing nanoparticles are therapeutic for Staphylococcus aureus abscesses in a murine model of infection.

Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infection.

Cryptococcus neoformans responds to mannitol by increasing capsule size in vitro and in vivo.

Extracellular vesicles from Cryptococcus neoformans modulate macrophage functions.

Aggregation of Streptococcus pneumoniae by a pneumococcal capsular polysaccharide-specific human monoclonal IgM correlates with antibody efficacy in vivo.

Demonstration of antibiofilm and antifungal efficacy of chitosan against candidal biofilms, using an in vivo central venous catheter model.

Melanin-covered nanoparticles for protection of bone marrow during radiation therapy of cancer.

DIAGNOSIS OF HISTOPLASMOSIS.

A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis.

Characterization of yeast extracellular vesicles: evidence for the participation of different pathways of cellular traffic in vesicle biogenesis.

Fungal cell gigantism during mammalian infection.

Vesicular Trans-Cell Wall Transport in Fungi: A Mechanism for the Delivery of Virulence-Associated Macromolecules?

Phenylalanine hydroxylase (PAH) from the lower eukaryote Leishmania major.

The stearoyl-coenzyme A desaturase 1 is essential for virulence and membrane stress in Candida parapsilosis through unsaturated fatty acid production.

Monoclonal antibodies against peptidorhamnomannans of Scedosporium apiospermum enhance the pathogenicity of the fungus.

Autophagy-related lipase FgATG15 of Fusarium graminearum is important for lipid turnover and plant infection.

The use of nitric oxide releasing nanoparticles as a treatment against Acinetobacter baumannii in wound infections.

Biogenesis of extracellular vesicles in yeast: Many questions with few answers.

Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice.

Candida parapsilosis fat storage-inducing transmembrane (FIT) protein 2 regulates lipid droplet formation and impacts virulence.

Melanogenesis in dermatophyte species in vitro and during infection.

Susceptibility of Gram-positive and -negative bacteria to novel nitric oxide-releasing nanoparticle technology.

A rat model of neonatal candidiasis demonstrates the importance of lipases as virulence factors for Candida albicans and Candida parapsilosis.

Detection of antibodies against Paracoccidioides brasiliensis melanin in in vitro and in vivo studies during infection.

The homeostasis of iron, copper, and zinc in paracoccidioides brasiliensis, cryptococcus neoformans var. Grubii, and cryptococcus gattii: a comparative analysis.

Lipid droplet formation protects against gluco/lipotoxicity in Candida parapsilosis: an essential role of fatty acid desaturase Ole1.

Sodium butyrate inhibits pathogenic yeast growth and enhances the functions of macrophages.

Improved antimicrobial efficacy with nitric oxide releasing nanoparticle generated S-nitrosoglutathione.

Secreted lipases supply fatty acids for yeast growth in the absence of de novo fatty acid synthesis.

Vesicular transport systems in fungi.

Effects of microplusin, a copper-chelating antimicrobial peptide, against Cryptococcus neoformans.

Surface architecture of histoplasma capsulatum.

Radioimmunotherapy of fungal diseases: the therapeutic potential of cytocidal radiation delivered by antibody targeting fungal cell surface antigens.

The Identification of Gene Duplication and the Role of Secreted Aspartyl Proteinase 1 in Candida parapsilosis Virulence.

Nitric Oxide-Releasing Nanoparticles Accelerate Wound Healing by Promoting Fibroblast Migration and Collagen Deposition.