Kristin A. Hogquist

CD53, a thymocyte selection marker whose induction requires a lower affinity TCR-MHC interaction than CD69, but is up-regulated with slower kinetics.

A spontaneous CD8 T cell-dependent autoimmune disease to an antigen expressed under the human keratin 14 promoter.

Rare, structurally homologous self-peptides promote thymocyte positive selection.

Sweet 'n' sour: the impact of differential glycosylation on T cell responses.

Positive and negative selection of T cells.

Antigen receptor selection by editing or downregulation of V(D)J recombination.

Receptor sensitivity: when T cells lose their sense of self.

The central tolerance response to male antigen in normal mice is deletion and not receptor editing.

Thymocyte sensitivity and supramolecular activation cluster formation are developmentally regulated: a partial role for sialylation.

Central tolerance to self-antigen expressed by cortical epithelial cells.

Langerhans cells activate naive self-antigen-specific CD8 T cells in the steady state.

The regulated expression of a diverse set of genes during thymocyte positive selection in vivo.

The fourth way? Harnessing aggressive tendencies in the thymus.

Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.

The timing of TCR alpha expression critically influences T cell development and selection.

A requirement for sustained ERK signaling during thymocyte positive selection in vivo.

Central tolerance: learning self-control in the thymus.

Conditioning of Langerhans cells induced by a primary CD8 T cell response to self-antigen in vivo.

Kruppel-like factor 2 regulates thymocyte and T-cell migration.

Tec kinases in T cell development: a clue behind the mask?

Transcriptional analysis of clonal deletion in vivo.

Thymic emigration revisited.

Identification of a novel population of Langerin+ dendritic cells.

Langerin expressing cells promote skin immune responses under defined conditions.

T-cell migration: Kruppeled T cells move again.

Thymic emigration: when and how T cells leave home.

Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla.

Immunodeficiency: when T cells are stuck at home.

Central tolerance: what have we learned from mice?

Thymic emigration: sphingosine-1-phosphate receptor-1-dependent models and beyond.

Langerhans cells are not required for the CD8 T cell response to epidermal self-antigens.

Treg cells meet their limit.

Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire.

KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors.

Epidermal Langerhans cells are not required for UV-induced immunosuppression.

Why CD8+ T cells need diversity when growing up.

Krüppel-like factor 2 regulates trafficking and homeostasis of gammadelta T cells.

T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells.

Acute ablation of Langerhans cells enhances skin immune responses.

Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells.

Krüppel-like factor 2 (KLF2) regulates B-cell reactivity, subset differentiation, and trafficking molecule expression.

Postselection thymocyte maturation and emigration are independent of IL-7 and ERK5.

Progress and problems in understanding and managing primary Epstein-Barr virus infections.

Alternative memory in the CD8 T cell lineage.

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse.

Selection of self-reactive T cells in the thymus.

TCR affinity in thymic development.

Krüppel-like factors in lymphocyte biology.

Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination.

Pillars article: T cell receptor antagonist peptides induce positive selection. Cell. 1994. 76: 17-27.

Primary Epstein-Barr virus infection does not erode preexisting CD8⁺ T cell memory in humans.

Death diverted, but to what?

T-cell tolerance: central and peripheral.

Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.

Behavioral, virologic, and immunologic factors associated with acquisition and severity of primary Epstein-Barr virus infection in university students.

Murine thymic selection quantified using a unique method to capture deleted T cells.

Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selection.

Virtual memory CD8 T cells display unique functional properties.

Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells.

Distinct temporal patterns of T cell receptor signaling during positive versus negative selection in situ.

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells.

Primary EBV infection induces an expression profile distinct from other viruses but similar to hemophagocytic syndromes.

From pre-DP, post-DP, SP4, and SP8 Thymocyte Cell Counts to a Dynamical Model of Cortical and Medullary Selection.

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.

Cutting edge: NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus.

Antigen-dependent versus -independent activation of invariant NKT cells during infection.

Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see).

TCR Affinity and Tolerance Mechanisms Converge To Shape T Cell Diabetogenic Potential.