Mathias Ziegler

Crystallization and preliminary X-ray analysis of human nicotinamide mononucleotide adenylyltransferase (NMNAT).

Crystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with NMN.

ATP-dependent selection between single nucleotide and long patch base excision repair.

The new life of a centenarian: signalling functions of NAD(P).

NAD+ surfaces again.

Poly(ADP-ribosylation) and genomic stability.

Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms.

A vital link between energy and signal transduction.

Time sensing by NAADP receptors.

The power to reduce: pyridine nucleotides--small molecules with a multitude of functions.

Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1.

Emerging functions of extracellular pyridine nucleotides.

NAD kinase levels control the NADPH concentration in human cells.

Refinement of a radioreceptor binding assay for nicotinic acid adenine dinucleotide phosphate.

Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix.

Designed protein-protein association.

Conformational changes and reaction of clostridial glycosylating toxins.

Inhibition of the glucosyltransferase activity of clostridial Rho/Ras-glucosylating toxins by castanospermine.

Application of a coupled enzyme assay to characterize nicotinamide riboside kinases.

Emerging roles of NAD+ and its metabolites in cell signaling.

Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro.

Proteomic response of human neuroblastoma cells to azaspiracid-1.

The NMN/NaMN adenylyltransferase (NMNAT) protein family.

Application of reverse-phase HPLC to quantify oligopeptide acetylation eliminates interference from unspecific acetyl CoA hydrolysis.

Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity.

Visualization of subcellular NAD pools and intra-organellar protein localization by poly-ADP-ribose formation.

The phosphate makes a difference: cellular functions of NADP.

Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases.

Compartmentation of NAD+-dependent signalling.

Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.

Progress in the function and regulation of ADP-Ribosylation.

Pathway analysis of NAD+ metabolism.

NAD(+) biosynthesis and salvage--a phylogenetic perspective.

ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose).

The NAD metabolome--a key determinant of cancer cell biology.

NAD and ADP-ribose metabolism in mitochondria.

Pharmacology of ADP-ribosylation.

Physiology of ADP-ribosylation.

Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data.

NAD biosynthesis in humans--enzymes, metabolites and therapeutic aspects.

Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform.

Carbohydrate metabolism during vertebrate appendage regeneration: what is its role? How is it regulated?: A postulation that regenerating vertebrate appendages facilitate glycolytic and pentose phosphate pathways to fuel macromolecule biosynthesis.

Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels.

Separating NADH and NADPH fluorescence in live cells and tissues using FLIM.

Sequence divergence and diversity suggests ongoing functional diversification of vertebrate NAD metabolism.

The PHD finger of p300 influences its ability to acetylate histone and non-histone targets.

NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms.

An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.

The human NAD metabolome: Functions, metabolism and compartmentalization.

Generation, Release, and Uptake of the NAD Precursor Nicotinic Acid Riboside by Human Cells.

Subcellular Distribution of NAD+ between Cytosol and Mitochondria Determines the Metabolic Profile of Human Cells.

SIRT2 inactivation reveals a subset of hyperacetylated perinuclear microtubules inaccessible to HDAC6.