Michelle Krogsgaard

Direct observation of ligand recognition by T cells.

Distinct molecular mechanisms account for the specificity of two different T-cell receptors.

Dynamics of cell surface molecules during T cell recognition.

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation.

Linking molecular and cellular events in T-cell activation and synapse formation.

Quantitative imaging of lymphocyte membrane protein reorganization and signaling.

How T cells 'see' antigen.

Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity.

Selection of aberrant class II restricted CD8+ T cells in NOD mice expressing a glutamic acid decarboxylase (GAD)65-specific T cell receptor transgene.

High-level bacterial secretion of single-chain alphabeta T-cell receptors.

Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions.

T cells as a self-referential, sensory organ.

A role for "self" in T-cell activation.

In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange.

Developing a multidisciplinary prospective melanoma biospecimen repository to advance translational research.

Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection.

Attenuated T cell responses to a high-potency ligand in vivo.

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation.