Narla Mohandas

Identification of a functional role for lipid asymmetry in biological membranes: Phosphatidylserine-skeletal protein interactions modulate membrane stability.

Shear-response of the spectrin dimer-tetramer equilibrium in the red blood cell membrane.

Ribosomal protein S19 expression during erythroid differentiation.

Phosphatidylserine binding sites in erythroid spectrin: location and implications for membrane stability.

Red blood cell blood group antigens: structure and function.

Phosphatidylserine binding sites in red cell spectrin.

Phospholipid binding by proteins of the spectrin family: a comparative study.

Blood group antigens in health and disease.

The hydration state of human red blood cells and their susceptibility to invasion by Plasmodium falciparum.

Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis.

Nuclear substructure reorganization during late-stage erythropoiesis is selective and does not involve caspase cleavage of major nuclear substructural proteins.

Structural and functional studies of interaction between Plasmodium falciparum knob-associated histidine-rich protein (KAHRP) and erythrocyte spectrin.

Identification and functional characterization of protein 4.1R and actin-binding sites in erythrocyte beta spectrin: regulation of the interactions by phosphatidylinositol-4,5-bisphosphate.

High frequency of alternative first exons in erythroid genes suggests a critical role in regulating gene function.

Mammalian alpha I-spectrin is a neofunctionalized polypeptide adapted to small highly deformable erythrocytes.

Conformational stabilities of the structural repeats of erythroid spectrin and their functional implications.

A Maurer's cleft-associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells.

Phosphatidylinositol-4,5-biphosphate (PIP2) differentially regulates the interaction of human erythrocyte protein 4.1 (4.1R) with membrane proteins.

Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation.

Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton.

Tropomyosin modulates erythrocyte membrane stability.

Thermal stabilities of brain spectrin and the constituent repeats of subunits.

Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain.

Erythrocyte G protein as a novel target for malarial chemotherapy.

The ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum stabilizes spectrin tetramers and suppresses further invasion.

Cytoplasmic remodeling of erythrocyte raft lipids during infection by the human malaria parasite Plasmodium falciparum.

Interactions of Plasmodium falciparum erythrocyte membrane protein 3 with the red blood cell membrane skeleton.

Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) destabilizes erythrocyte membrane skeleton.

The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3.

Intrasplicing coordinates alternative first exons with alternative splicing in the protein 4.1R gene.

Fluctuations of the red blood cell membrane: relation to mechanical properties and lack of ATP dependence.

Disorders of red cell membrane.

Morphological and functional platelet abnormalities in Berkeley sickle cell mice.

Integral protein linkage and the bilayer-skeletal separation energy in red blood cells.

In vivo studies support the role of trafficking and cytoskeletal-binding motifs in the interaction of MESA with the membrane skeleton of Plasmodium falciparum-infected red blood cells.

Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane.

Erythroblastic islands: niches for erythropoiesis.

Characterization of glycolytic enzyme interactions with murine erythrocyte membranes in wild-type and membrane protein knockout mice.

Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.

Adhesive activity of Lu glycoproteins is regulated by interaction with spectrin.

Functional alteration of red blood cells by a megadalton protein of Plasmodium falciparum.

Red cell membrane: past, present, and future.

Cytoskeletal protein 4.1R negatively regulates T-cell activation by inhibiting the phosphorylation of LAT.

A Golgi-associated protein 4.1B variant is required for assimilation of proteins in the membrane.

Protein 4.1R links E-cadherin/beta-catenin complex to the cytoskeleton through its direct interaction with beta-catenin and modulates adherens junction integrity.

Targeted deletion of the gamma-adducin gene (Add3) in mice reveals differences in alpha-adducin interactions in erythroid and nonerythroid cells.

Adducin forms a bridge between the erythrocyte membrane and its cytoskeleton and regulates membrane cohesion.

The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume.

Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis.

Malaria, erythrocytic infection, and anemia.

Membrane remodeling during reticulocyte maturation.

Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: the role of protein kinase C, Rac GTPases, and reactive oxygen species.

Hereditary spherocytosis and hereditary elliptocytosis: aberrant protein sorting during erythroblast enucleation.

Control of erythrocyte membrane-skeletal cohesion by the spectrin-membrane linkage.

A transgenic mouse model demonstrates a dominant negative effect of a point mutation in the RPS19 gene associated with Diamond-Blackfan anemia.

The erythroid niche: molecular processes occurring within erythroblastic islands.

ATP-dependent mechanism protects spectrin against glycation in human erythrocytes.

Similarities and differences in the structure and function of 4.1G and 4.1R135, two protein 4.1 paralogues expressed in erythroid cells.

Comprehensive characterization of expression patterns of protein 4.1 family members in mouse adrenal gland: implications for functions.

"Capping": necessary for graduation.

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice.

Efficient in vivo manipulation of alternative pre-mRNA splicing events using antisense morpholinos in mice.

The sensing of poorly deformable red blood cells by the human spleen can be mimicked in vitro.

Inter-subunit interactions in erythroid and non-erythroid spectrins.

Erythroblastic islands, terminal erythroid differentiation and reticulocyte maturation.

Congenital erythropoietic porphyria: characterization of murine models of the severe common (C73R/C73R) and later-onset genotypes.

Membrane assembly during erythropoiesis.

Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility.

Cysteine shotgun-mass spectrometry (CS-MS) reveals dynamic sequence of protein structure changes within mutant and stressed cells.

Phosphorylation-dependent perturbations of the 4.1R-associated multiprotein complex of the erythrocyte membrane.

The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.

Protein 4.1R regulates cell adhesion, spreading, migration and motility of mouse keratinocytes by modulating surface expression of beta1 integrin.

Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity.

"Baby" red cells to the rescue.

Native ultrastructure of the red cell cytoskeleton by cryo-electron tomography.

Exit strategy: one that works.

Deep intron elements mediate nested splicing events at consecutive AG dinucleotides to regulate alternative 3' splice site choice in vertebrate 4.1 genes.

Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients.

Quantitative assessment of sensing and sequestration of spherocytic erythrocytes by the human spleen.

Novel aspects of Kindlin-3 function in humans based on a new case of leukocyte adhesion deficiency III.

Identification of a novel role for dematin in regulating red cell membrane function by modulating spectrin-actin interaction.

Malaria and human red blood cells.

The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons.

Quantitative analysis of murine terminal erythroid differentiation in vivo: novel method to study normal and disordered erythropoiesis.

Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease.

Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo.

Impaired intestinal calcium absorption in protein 4.1R-deficient mice due to altered expression of plasma membrane calcium ATPase 1b (PMCA1b).

To shrink or not to shrink.

A bacterial phosphatase-like enzyme of the malaria parasite Plasmodium falciparum possesses tyrosine phosphatase activity and is implicated in the regulation of band 3 dynamics during parasite invasion.

Membrane peroxidation and methemoglobin formation are both necessary for band 3 clustering: mechanistic insights into human erythrocyte senescence.

Identification of binding domains on red blood cell glycophorins for Babesia divergens.

Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice.

Interaction of Plasmodium falciparum knob-associated histidine-rich protein (KAHRP) with erythrocyte ankyrin R is required for its attachment to the erythrocyte membrane.

Significant biochemical, biophysical and metabolic diversity in circulating human cord blood reticulocytes.

An open-and-shut case?

Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c.

A 130-kDa protein 4.1B regulates cell adhesion, spreading, and migration of mouse embryo fibroblasts by influencing actin cytoskeleton organization.

A dynamic alternative splicing program regulates gene expression during terminal erythropoiesis.

Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development.

Abnormal red cell features associated with hereditary neurodegenerative disorders: the neuroacanthocytosis syndromes.

Global transcriptome analyses of human and murine terminal erythroid differentiation.

KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia.

Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia.

The iron fist: malaria and hepcidin.

Inactivation of Rb and E2f8 synergizes to trigger stressed DNA replication during erythroid terminal differentiation.

Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification.

Isolation and transcriptome analyses of human erythroid progenitors: BFU-E and CFU-E.

Abnormal erythroid maturation leads to microcytic anemia in the TSAP6/Steap3 null mouse model.

Altered chromatin occupancy of master regulators underlies evolutionary divergence in the transcriptional landscape of erythroid differentiation.

Malaria induces anemia through CD8+ T cell-dependent parasite clearance and erythrocyte removal in the spleen.

Human and murine erythropoiesis.

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria.

Interactions between Plasmodium falciparum skeleton-binding protein 1 and the membrane skeleton of malaria-infected red blood cells.

Jekyll and Hyde: the role of heme oxygenase-1 in erythroid biology.

The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis.

More than one way to shrink.

The erythroblastic island as an emerging paradigm in the anemia of inflammation.

The human Kell blood group binds the erythroid 4.1R protein: new insights into the 4.1R-dependent red cell membrane complex.

A dynamic intron retention program enriched in RNA processing genes regulates gene expression during terminal erythropoiesis.

Diagnostic tool for red blood cell membrane disorders: Assessment of a new generation ektacytometer.

Protein 4.1G Regulates Cell Adhesion, Spreading, and Migration of Mouse Embryonic Fibroblasts through the β1 Integrin Pathway.

Human STEAP3 mutations with no phenotypic red cell changes.

Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors.

Long-term follow-up of subtotal splenectomy for hereditary spherocytosis: a single-center study.

No evidence for cell activation or brain vaso-occlusion with plerixafor mobilization in sickle cell mice.

ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia.

A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages.

Malaria Parasite Proteins and Their Role in Alteration of the Structure and Function of Red Blood Cells.

An Unrecognized Function of Cholesterol: Regulating the Mechanism Controlling Membrane Phospholipid Asymmetry.

Comprehensive Proteomic Analysis of Human Erythropoiesis.

Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function.

The road not taken?

Exome sequencing results in successful diagnosis and treatment of a severe congenital anemia.

Unexpected role for p19INK4d in posttranscriptional regulation of GATA1 and modulation of human terminal erythropoiesis.

Characterization, regulation, and targeting of erythroid progenitors in normal and disordered human erythropoiesis.

Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice.

Distinct roles for TET family proteins in regulating human erythropoiesis.

Measurements of red cell deformability and hydration reflect HbF and HbA2 in blood from patients with sickle cell anemia.

Confounding in ex vivo models of Diamond-Blackfan anemia.

Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating.

Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis.

Enhancing diversity in the hematology biomedical research workforce: A mentoring program to improve the odds of career success for early stage investigators.

Unraveling Macrophage Heterogeneity in Erythroblastic Islands.

Case series supporting heme detoxification via therapeutic plasma exchange in acute multiorgan failure syndrome resistant to red blood cell exchange in sickle cell disease.

Developmental Differences Between Neonatal and Adult Human Erythropoiesis.

The severe phenotype of Diamond-Blackfan anemia is modulated by heat shock protein 70.