Per Svenningsen

Prostaglandin E2 EP2 and EP4 receptor activation mediates cAMP-dependent hyperpolarization and exocytosis of renin in juxtaglomerular cells.

Plasmin in nephrotic urine activates the epithelial sodium channel.

Hypotonicity-induced Renin exocytosis from juxtaglomerular cells requires aquaporin-1 and cyclooxygenase-2.

Proteinuric diseases with sodium retention: Is plasmin the link?

Physiological regulation of epithelial sodium channel by proteolysis.

Regulation of renin secretion by renal juxtaglomerular cells.

Urinary plasmin activates collecting duct ENaC current in preeclampsia.

Histamine-dependent prolongation by aldosterone of vasoconstriction in isolated small mesenteric arteries of the mouse.

ATP releasing connexin 30 hemichannels mediate flow-induced calcium signaling in the collecting duct.

T-type Ca(2+) channels facilitate NO-formation, vasodilatation and NO-mediated modulation of blood pressure.

Plasmin in urine from patients with type 2 diabetes and treatment-resistant hypertension activates ENaC in vitro.

The epithelial sodium channel γ-subunit is processed proteolytically in human kidney.

Urinary serine proteases and activation of ENaC in kidney--implications for physiological renal salt handling and hypertensive disorders with albuminuria.

Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells.

Aberrant glomerular filtration of urokinase-type plasminogen activator in nephrotic syndrome leads to amiloride-sensitive plasminogen activation in urine.

Stressed podocytes - Bestrophin-3 is not just Bestrophin-3.

Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.

Urine exosomes from healthy and hypertensive pregnancies display elevated level of α-subunit and cleaved α- and γ-subunits of the epithelial sodium channel-ENaC.

Expression of transcellular and paracellular calcium and magnesium transport proteins in renal and intestinal epithelia during lactation.

Physiology and pathophysiology of the plasminogen system in the kidney.

Albuminuria in kidney transplant recipients is associated with increased urinary serine proteases and activation of the epithelial sodium channel.

Hydronephrosis is associated with elevated plasmin in urine in pediatric patients and rats and changes in NCC and γ-ENaC abundance in rat kidney.

H-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidney.

The acute blood pressure-lowering effect of amiloride is independent of endothelial ENaC and eNOS in humans and mice.

Aberrant neuronal differentiation is common in glioma but is associated neither with epileptic seizures nor with better survival.

A bacterial display system for effective selection of protein-biotin ligase BirA variants with novel peptide specificity.

In human nephrectomy specimens, the kidney level of tubular transport proteins does not correlate with their abundance in urinary extracellular vesicles.

Urinary extracellular vesicles: Origin, role as intercellular messengers and biomarkers; efficient sorting and potential treatment options.

Urokinase-type plasminogen activator contributes to amiloride-sensitive sodium retention in nephrotic range glomerular proteinuria in mice.

Dietary Na intake in healthy humans changes the urine extracellular vesicle prostasin abundance while vesicle excretion rate, NCC and ENaC are not altered.

Nephrotic syndrome is associated with increased plasma K concentration, intestinal K losses and attenuated urinary K excretion - studies in rats and humans.