Stephen M. Beverley

Putting the Leishmania genome to work: functional genomics by transposon trapping and expression profiling.

Non-pathogenic trypanosomatid protozoa as a platform for protein research and production.

Characterization of quinonoid-dihydropteridine reductase (QDPR) from the lower eukaryote Leishmania major.

Leishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viability.

Protozomics: trypanosomatid parasite genetics comes of age.

Transposon mutagenesis of Mycobacterium marinum identifies a locus linking pigmentation and intracellular survival.

Functional identification of galactosyltransferases (SCGs) required for species-specific modifications of the lipophosphoglycan adhesin controlling Leishmania major-sand fly interactions.

Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite Leishmania.

Identification of genes encoding arabinosyltransferases (SCA) mediating developmental modifications of lipophosphoglycan required for sand fly transmission of leishmania major.

The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts.

Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major.

Functional genetic identification of PRP1, an ABC transporter superfamily member conferring pentamidine resistance in Leishmania major.

Persistence without pathology in phosphoglycan-deficient Leishmania major.

The H region HTBF gene mediates terbinafine resistance in Leishmania major.

An in vitro system for developmental and genetic studies of Leishmania donovani phosphoglycans.

Sphingolipids are essential for differentiation but not growth in Leishmania.

Vaccination with phosphoglycan-deficient Leishmania major protects highly susceptible mice from virulent challenge without inducing a strong Th1 response.

The LPG1 gene family of Leishmania major.

Expression profiling using random genomic DNA microarrays identifies differentially expressed genes associated with three major developmental stages of the protozoan parasite Leishmania major.

In vitro shuttle mutagenesis using engineered mariner transposons.

Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies.

The application of gene expression microarray technology to kinetoplastid research.

Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites.

Flypaper for parasites.

Reconstitution of GDP-mannose transport activity with purified Leishmania LPG2 protein in liposomes.

从诱导细菌或原生动物寄生虫利什曼原虫主要挑战的沙飞白蛉 duboscqi 防御的表征。

Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis.

Eukaryotic UDP-galactopyranose mutase (GLF gene) in microbial and metazoal pathogens.

Identification of a DNA fragment that increases mitotic stability of episomal linear DNAs in Leishmania major.

The genome of the kinetoplastid parasite, Leishmania major.

Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design.

Demonstration by heterologous expression that the Leishmania SCA1 gene encodes an arabinopyranosyltransferase.

Immunization with persistent attenuated Delta lpg2 Leishmania major parasites requires adjuvant to provide protective immunity in C57BL/6 mice.

Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modifications.

Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.

Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania.

A lipophosphoglycan-independent development of Leishmania in permissive sand flies.

Two functionally divergent UDP-Gal nucleotide sugar transporters participate in phosphoglycan synthesis in Leishmania major.

Comparisons of mutants lacking the Golgi UDP-galactose or GDP-mannose transporters establish that phosphoglycans are important for promastigote but not amastigote virulence in Leishmania major.

Characterization of inositol phosphorylceramides from Leishmania major by tandem mass spectrometry with electrospray ionization.

The role of the mitochondrial glycine cleavage complex in the metabolism and virulence of the protozoan parasite Leishmania major.

Phylogenomic and functional analysis of pterin-4a-carbinolamine dehydratase family (COG2154) proteins in plants and microorganisms.

Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45-/- mice.

Developmentally regulated sphingolipid synthesis in African trypanosomes.

Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicana.

Migratory dermal dendritic cells act as rapid sensors of protozoan parasites.

Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major.

Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts.

Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector.

A novel role for Stat1 in phagosome acidification and natural host resistance to intracellular infection by Leishmania major.

Regulated expression of the Leishmania major surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins.

Leishmania major lacking arginase (ARG) are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice.

PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major.

The enzymes of the 10-formyl-tetrahydrofolate synthetic pathway are found exclusively in the cytosol of the trypanosomatid parasite Leishmania major.

Leishmania major phosphoglycans influence the host early immune response by modulating dendritic cell functions.

Inoculation of killed Leishmania major into immune mice rapidly disrupts immunity to a secondary challenge via IL-10-mediated process.

A transposon toolkit for gene transfer and mutagenesis in protozoan parasites.

Identification of transport-critical residues in a folate transporter from the folate-biopterin transporter (FBT) family.

Degradation of host sphingomyelin is essential for Leishmania virulence.

Phospholipid and sphingolipid metabolism in Leishmania.

Leishmania major glycosylation mutants require phosphoglycans (lpg2-) but not lipophosphoglycan (lpg1-) for survival in permissive sand fly vectors.

Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies.

Deletion of UDP-glucose pyrophosphorylase reveals a UDP-glucose independent UDP-galactose salvage pathway in Leishmania major.

Monitoring the efficacy of antimicrobial photodynamic therapy in a murine model of cutaneous leishmaniasis using L. major expressing GFP.

Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage.

A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life.

Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity.

Remodeling of protein and mRNA expression in Leishmania mexicana induced by deletion of glucose transporter genes.

Phenylalanine hydroxylase (PAH) from the lower eukaryote Leishmania major.

Sphingolipids in parasitic protozoa.

Retention and loss of RNA interference pathways in trypanosomatid protozoans.

Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern.

Differential microbicidal effects of human histone proteins H2A and H2B on Leishmania promastigotes and amastigotes.

Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis.

The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing.

Muco-cutaneous leishmaniasis in the New World: the ultimate subversion.

Folate metabolic pathways in Leishmania.

[Mucocutaneous leishmaniasis and an undesired passenger].

Killed but metabolically active Leishmania as a novel whole-cell vaccine for visceral leishmaniasis.