In Vitro Model Integrating Substrate Stiffness and Flow to Study Endothelial Cell ResponsesMohammad Hamrangsekachaee 1, Yu Chen 1, Emily R. Tressler 2, Sidi A. Bencherif 1,2,3,4, Eno E. Ebong 1,2,5
1Chemical Engineering Department, Northeastern University, 2Bioengineering Department, Northeastern University, 3Laboratoire de BioMécanique et BioIngénierie (BMBI), UMR CNRS, Sorbonne Universités, Université de Technologie of Compiègne (UTC), 4Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, 5Neuroscience Department, Albert Einstein College of Medicine
We synthesized and characterized a tunable gelatin-based substrate for culturing vascular endothelial cells (ECs) under relevant vascular flow conditions. This biomimetic surface replicates both physiological and pathological conditions, enabling the study of mechanical forces on EC behavior and advancing our understanding of vascular health and disease mechanisms.
