Establishment and Validation of a Rat Model of Pulmonary Arterial Hypertension Associated with Pulmonary FibrosisQian Jiang *1, Dongmei Wen *1, Fang Peng *2, Wei Hong 3, Xin Fu 3, Yuanhui Xiong 1, Chongyuan Ren 1, Xuanyi Li 1, Dansha Zhou 1,4, Jian Wang 1,4, Yuqin Chen 1
1State Key Laboratory of Respiratory Diseases, National Center for Respiratory Medicine, Guangdong Key Laboratory of Vascular Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 2Department of Critical Care Medicine, The Third Affiliated Hospital of Guangzhou Medical University, 3GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, 4Guangzhou laboratory, Guangzhou International Bio Island
Here, the method of inducing pulmonary arterial hypertension associated with pulmonary fibrosis (PF-PH) rat model by injecting bleomycin into the airway is introduced. We also provide a step-by-step approach to validate this animal model.
