Shimadzu (China) Co., Ltd.

1 ARTICLES PUBLISHED IN JoVE

Biochemistry

Determining Four Components in a Lipid Nanoparticle RNA Delivery System by Liquid Chromatography Combined with Evaporative Light Scattering Detector

Jia Zheng¹, Huijuan Jiang¹, Junqi Huang², Qiaoxia Liu¹, Hongyuan Hao¹

¹Shimadzu (China) Co., Ltd., ²Medical College of Fudan University

Here, we establish a quantitative analysis method for four components in a lipid nanoparticle (LNP) RNA delivery system using high-performance liquid chromatography combined with an evaporative light scattering detector (ELSD). The method has good separation, high sensitivity, and high efficiency.