In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator MouseRichárd Sinkó 1,2, Petra Mohácsik 1, Csaba Fekete *3, Balázs Gereben *1
1Laboratory of Molecular Cell Metabolism, Institute of Experimental Medicine, 2János Szentágothai PhD School of Neurosciences, Semmelweis University, 3Laboratory of Integrative Neuroendocrinology, Institute of Experimental Medicine
The Thyroid Hormone Action Indicator mouse model was developed to enable tissue-specific quantification of local thyroid hormone action using its endogenous regulatory machinery. Recently, it has been shown that the model is suitable for characterizing endocrine-disrupting chemicals interacting with thyroid hormone economy, both by ex vivo and in vivo methodologies.
