An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for TreatmentHao Wu 1, Ana R. Rodriguez 2, Bernd W. Spur 2, Venkat Venkataraman 1,2
1Graduate School of Biomedical Sciences, Rowan University, 2Department of Cell Biology, Rowan University School of Osteopathic Medicine
A low-cost, easy-to-use and powerful system is established to evaluate potential treatments that could ameliorate blood retinal barrier breach induced by histamine. Blood vessel leakage, Müller cell activation and the continuity of neuronal processes are utilized to assess the damage response and its reversal with a potential drug, lipoxin A4.
