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Tungwah Hospital of Sun Yat-sen University

1 ARTICLES PUBLISHED IN JoVE

Developmental Biology

A Mini-Invasive Internal Fixation Technique for Studying Immobilization-Induced Knee Flexion Contracture in Rats

Shihai Jiang^*1, Xiaoyou Yi^*3, Yuansen Luo², Dongjie Yu¹, Yuangao Liu¹, Fei Zhang^1,4, Lei Zhu², Kun Wang¹

¹Department of Joint and Trauma Surgery, The Third Affiliated Hospital of Sun Yat-sen University, ²Department of Plastic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, ³Department of Bone Surgery, Tungwah Hospital of Sun Yat-sen University, ⁴Department of Othopaedic Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University

Here, we present a protocol to describe a minimally invasive technique for knee joint immobilization in a rat model. This reproducible protocol, basing on muscle-gap separation modus and the mini-incision skill, is suitable for studying the underlying molecular mechanism of acquired joint contracture.