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Beth Israel Deaconess Med Center

6 ARTICLES PUBLISHED IN JoVE

Neuroscience

A Novel Approach for Documenting Phosphenes Induced by Transcranial Magnetic Stimulation

Seth Elkin-Frankston¹, Peter J. Fried¹, Alvaro Pascual-Leone², R. J. Rushmore III¹, Antoni Valero-Cabré^1,3

¹Department of Anatomy and Neurobiology, Boston University School of Medicine, ²Department of Neurology, Beth Israel Deaconess Med Center, ³Centre de Recherche de l'institut du Cerveau et la Moelle Epinière (CRICM), Centre National de la Recherche Scientifique (CNRS)

Phosphenes are transient percepts of light that can be induced by applying Transcranial Magnetic Stimulation (TMS) to visually sensitive regions of cortex. We demonstrate a standard protocol for determining the phosphene threshold value and introduce a novel method for quantifying and analyzing perceived phosphenes.

Neuroscience

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Mark A. Halko¹, Mark C. Eldaief¹, Jared C. Horvath¹, Alvaro Pascual-Leone¹

¹Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center

In this article, we examine the methodology and considerations relevant to the combination of TMS and fMRI to examine the effects of brain stimulation on the default network.

Neuroscience

TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism

Lindsay M. Oberman¹, Jared C. Horvath¹, Alvaro Pascual-Leone¹

¹Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center

In this article, we examine the effects of Theta-Burst TMS stimulation on cortical plasticity in individuals suffering from Fragile X syndrome and individuals on the autistic spectrum.

Neuroscience

State-Dependency Effects on TMS: A Look at Motive Phosphene Behavior

Umer Najib¹, Jared C. Horvath¹, Juha Silvanto², Alvaro Pascual-Leone¹

¹Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, ²Brain Research Unit, Low Temperature Laboratory and Advanced magnetic Imaging Center, Aalto University School of Science and Technology

In this article, we examine the effects of visually relevant state dependency on TMS induced motive phosphenic presentations.

Neuroscience

The NeuroStar TMS Device: Conducting the FDA Approved Protocol for Treatment of Depression

Jared C. Horvath¹, John Mathews², Mark A. Demitrack², Alvaro Pascual-Leone¹

¹Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, ²Neuronetics, Inc.

In this article, we examine the methodology and considerations relevant to the FDA approved depression treatment protocol using the Neuronetics NeuroStar TMS device.

Medicine

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Mouhsin M. Shafi^1,2,3, Susan Whitfield-Gabrieli⁴, Catherine J. Chu^1,5, Alvaro Pascual-Leone^1,2,3, Bernard S. Chang^1,2

¹Department of Neurology, Harvard Medical School, ²Department of Neurology, Beth Israel Deaconess Medical Center, ³Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, ⁴Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, ⁵Department of Neurology, Massachusetts General Hospital

Resting-state functional-connectivity MRI has identified abnormalities in patients with a wide range of neuropsychiatric disorders, including epilepsy due to malformations of cortical development. Transcranial Magnetic Stimulation in combination with EEG can demonstrate that patients with epilepsy have cortical hyperexcitability in regions with abnormal connectivity.