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University of Kentucky College of Public Health

1 ARTICLES PUBLISHED IN JoVE

Neuroscience

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Diana M. Mathis¹, Jennifer L. Furman², Christopher M. Norris^2,3

¹Graduate Center for Gerontology, University of Kentucky College of Public Health, ²Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, ³Sanders-Brown Center on Aging, University of Kentucky College of Medicine

This article outlines procedures for preparing hippocampal slices from rats and transgenic mice for the study of synaptic alterations associated with brain aging and age-related neurodegenerative diseases, such as Alzheimer’s disease.