Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor CellsSandra Meyer 1,2, Philipp Wörsdörfer 1, Katharina Günther 1, Marc Thier 2,3, Frank Edenhofer 1,2
1Institute of Anatomy and Cell Biology, University of Würzburg, 2Institute of Reconstructive Neurobiology, University of Bonn, 3German Cancer Research Center, Heidelberg
Generation of induced pluripotent stem cells provides fascinating prospects for the derivation of autologous transplants. However, progression through a pluripotent state and laborious re-differentiation still hinders clinical translation. Here we describe the derivation of adult human fibroblasts and their direct conversion into induced neural progenitor cells and the subsequent differentiation into neural lineages.
