A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in RatsHui-Chun Ku 1, Shih-Yi Lee 2,3, Yuan-Kun Aden Wu 4, Kai-Chien Yang 1,5, Ming-Jai Su 1
1Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, 2Division of Pulmonary and Critical Care Medicine, Mackay Memorial Hospital, 3Mackay Medicine, Nursing and Management College, 4School of Medicine, National Taiwan University, 5Department of Internal Medicine, National Taiwan University Hosptial
A rat model of abdominal aortic constriction that induces cardiac hypertrophy and remodeling is described. An efficient, highly-reproducible, and minimally-invasive method is used to provide a simple yet useful platform for research in myocardial hypertrophy and dysfunction.
