Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular HypertrophyReza Tavakoli 1, Simona Nemska 1,2, Peiman Jamshidi 3, Max Gassmann 1, Nelly Frossard 2
1Institute of Veterinary Physiology and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, 2Laboratoire d'Innovation Thérapeutique, UMR7200, Université de Strasbourg - CNRS, 3Department of Cardiology, Canton Hospital Lucerne
The aim of this protocol is to describe step-by-step the technique of minimally invasive transverse aortic constriction (TAC) in mice. By elimination of intubation and ventilation which are mandatory for the commonly used standard procedure, minimally invasive TAC simplifies the operative procedure and reduces the strain put on the animal.
