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F. Hoffmann-La Roche, Ltd.

2 ARTICLES PUBLISHED IN JoVE

Behavior

An Objective and Child-friendly Assessment of Arm Function by Using a 3-D Sensor

Xing Chen¹, Detlef Wolf¹, Juliane Siebourg-Polster², Christian Czech³, Ulrike Bonati^4,5, Dirk Fischer^4,5, Omar Khwaja⁶, Martin Strahm¹

¹Data Science, Roche Pharmaceutical Research and Early Development Informatics, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd., ²Translational Technologies and Bioinformatics, Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd., ³Biomarker Experimental Medicine, Neuroscience, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd., ⁴Division of Neuropediatrics, University of Basel Children's Hospital, ⁵Department of Neurology, University of Basel Hospital, ⁶Translational Medicine, Neuroscience and Rare Diseases, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd.

An objective measure of muscle functions is challenging especially in children. Based on a commercially available digital 3-D sensor, a child-friendly gaming test was developed to assess upper limb function for clinical trials.

Biochemistry

Capture and Identification of RNA-binding Proteins by Using Click Chemistry-assisted RNA-interactome Capture (CARIC) Strategy

Rongbing Huang^*1,2, Mengting Han^*1,2, Liying Meng^1,3, Xing Chen^1,2,3,4,5

¹College of Chemistry and Molecular Engineering, Peking University, ²Beijing National Laboratory for Molecular Sciences, Peking University, ³Peking-Tsinghua Center for Life Sciences, Peking University, ⁴Synthetic and Functional Biomolecules Center, Peking University, ⁵Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Peking University

A detailed protocol for applying the click chemistry-assisted RNA-interactome capture (CARIC) strategy to identify proteins binding to both coding and noncoding RNAs is presented.