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Universitatsklinikum Hamburg-Eppendorf

2 ARTICLES PUBLISHED IN JoVE

Medicine

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Rahel Kluttig¹, Till Friedheim¹, Christoph Behem¹, Niko Zach¹, Rosannis Brown¹, Michael Graessler¹, Daniel Reuter¹, Christian Zöllner¹, Constantin Trepte¹

¹Universitatsklinikum Hamburg-Eppendorf

We present a protocol of creating right ventricular dysfunction in a pig model by inducing ARDS. We demonstrate invasive monitoring of left and right ventricular cardiac output using flow probes around the aorta and the pulmonary artery, as well as blood pressure measurements in the aorta and pulmonary artery.

Medicine

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion

Christoph R. Behem¹, Till Friedheim¹, Sabine H. Wipper², Hans O. Pinnschmidt³, Michael F. Graessler¹, Catharina Gaeth⁴, Hannes Holthusen¹, Adina Rapp⁵, Timo Suntrop¹, Josephina Haunschild⁶, Christian D. Etz⁶, Constantin J. C. Trepte¹

¹Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, ²University Department for Vascular Surgery and Department of Operative Medicine, Medical University of Innsbruck, ³Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, ⁴Department of Vascular Medicine, University Heart and Vascular Center Hamburg (UHZ), ⁵Department of Cardiology, Rostock University Medical Center, ⁶University Department for Cardiac Surgery, Heart Center Leipzig

Spinal cord microcirculation plays a pivotal role in spinal cord injury. Most methods do not allow real-time assessment of spinal cord microcirculation, which is essential for the development of microcirculation-targeted therapies. Here, we propose a protocol using Laser-Doppler-Flow Needle probes in a large animal model of ischemia/reperfusion.