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San Raffaele Roma Open University, Rome, Italy

1 ARTICLES PUBLISHED IN JoVE

Medicine

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Vincenzo Marzolla¹, Andrea Armani¹, Caterina Mammi¹, Alessandra Feraco¹, Massimiliano Caprio^1,2

¹Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy, ²Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy

We describe a protocol to induce atherosclerosis in the aortic root of ApoE^-/- mice fed with an atherogenic diet, through a continuous release of aldosterone. Methods to characterize plaque composition are also described.