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1 ARTICLES PUBLISHED IN JoVE

Chemistry

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Lesheng Zhang^*1, Tom Cambron^*2, Yueqing Niu¹, Zigang Xu³, Ning Su⁴, Hongyan Zheng⁴, Karl Wei², Paula Ray²

¹Procter and Gamble, Beijing Innovative center, ²Procter and Gamble, Mason Business Center, ³Department of Dermatology, Beijing Children's Hospital, ⁴Chinese Academy of Inspection and Quarantine

Here, we present a protocol for collection of confocal Raman spectra from human subjects in clinical studies combined with chemometric approaches for spectral outlier removal and the subsequent extraction of key features.