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Tampere University & Tampere University Hospital

2 ARTICLES PUBLISHED IN JoVE

Cancer Research

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Maria Vähätupa^*1, Toini Pemmari^*1, Ilkka Junttila^1,2, Marko Pesu^1,2, Tero A.H. Järvinen¹

¹Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, ²Department of Clinical Microbiology, Fimlab Laboratories

Two-stage skin carcinogenesis is induced by two topically applied chemicals. A mutagen 7,12-dimethylbenz[a]anthracene) causes mutations in the epidermal cells and a continuous application of general growth stimulator 12-O-tetradecanoyl phorbol-13-acetate accelerates skin papilloma formation.

Medicine

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Maria Vähätupa^1,2, Niina Jääskeläinen², Marc Cerrada-Gimenez², Rubina Thapa², Tero Järvinen¹, Giedrius Kalesnykas², Hannele Uusitalo-Järvinen^1,3

¹Faculty of Medicine and Health Technology, Tampere University & Tampere University Hospital, ²Experimentica Ltd, ³Eye Centre, Tampere University Hospital

Oxygen-induced retinopathy (OIR) can be used to model ischemic retinal diseases such as retinopathy of prematurity and proliferative diabetic retinopathy and to serve as a model for proof-of-concept studies in evaluating antiangiogenic drugs for neovascular diseases. OIR induces robust and reproducible neovascularization in the retina that can be quantified.