Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A MiceAriadna Carol Illa 1,2, Sarah Baumgarten 1, Dennis Danielsen 1, Karin Larsen 3, Torben Elm 1, Peter B. Johansen 4, Tom Knudsen 5, Brian Lauritzen 1, Mikael Tranholm 6, Carsten D. Ley 1
1Global Drug Discovery, Novo Nordisk A/S, 2Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 3Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 4Independent consultant, 5Catalyst Biosciences, 6Værløse Dyreklinik
The refined tail vein transection (TVT) bleeding model in anesthetized mice is a sensitive in vivo method for the assessment of hemophilic bleeding. This optimized TVT bleeding model uses blood loss and bleeding time as endpoints, refining other models and avoiding death as an endpoint.
