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The Seventh Affiliated Hospital of Sun Yat-sen University

3 ARTICLES PUBLISHED IN JoVE

Neuroscience

Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System

Xiaorui Wang¹, Yixun Su^1,2, Xuelian Hu^1,3, Jianqin Niu¹

¹Department of Histology and Embryology, Chongqing Key Laboratory of Neurobiology, Brain, and Intelligence Research Key Laboratory of Chongqing Education Commission, Third Military Medical University, ²Research Centre, The Seventh Affiliated Hospital of Sun Yat-sen University, ³School of Medicine, Chongqing University

Demyelination takes place in multiple central nervous system diseases. A reliable in vivo drug delivery technique is necessary for remyelinating drug testing. This protocol describes an osmotic pump-based method that allows long-term drug delivery directly into the brain parenchyma and improves the drug bioavailability, with broad application in remyelination research.

Neuroscience

Motor Imagery Brain-Computer Interface in Rehabilitation of Upper Limb Motor Dysfunction After Stroke

Yongchun Jiang^*1,2,3, Junxiao Yin^*4, Biyi Zhao^1,3,5, Yajie Zhang^1,3, Tingting Peng^1,3, Wanqi Zhuang^1,3, Siqing Wang^1,3, Siqi Huang^1,3, Meilian Zhong^1,3, Yanni Zhang^1,3, Guibing Tang^1,3, Bingchi Shen⁶, Haining Ou^1,3, Yuxin Zheng^*2,3, Qiang Lin^*2,3

¹Guangzhou Medical University, ²Department of Rehabilitation Medicine, The Seventh Affiliated Hospital of Sun Yat-sen University, ³Department of Rehabilitation Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, ⁴Clinical Medical College of Acupuncture and Rehabilitation, Guangzhou University of Traditional Chinese Medicine, ⁵School of Traditional Chinese Medicine, Jinan University, ⁶Department of Stomatology, Second Clinical Medical College, Dongguan Campus of Guangdong Medical University

The purpose of this study is to provide an important reference for the standard clinical operation of motor imagery brain-computer interface (MI-BCI) for upper limb motor dysfunction after stroke.

Neuroscience

Scalp Acupuncture Synchronizing Dual Task Gait for Enhancing Prefrontal Cortex Response

Jun Su¹, Yuanyuan Guo², Biyi Zhao³, Yongchun Jiang^2,4,5, Xi Qin⁶, Meilian Zhong^2,4,5, Dathan Nevin Dychingco Leung⁷, Junxiao Yin⁸, Qiang Lin^*4, Ke Chen^*9

¹Department of Orthopaedics, Anshun Hospital of Traditional Chinese Medicine, ²The Fifth Affiliated Hospital of Guangzhou Medical University, ³School of Traditional Chinese Medicine, Jinan University, ⁴Department of Rehabilitation Medicine, The Seventh Affiliated Hospital of Sun Yat-sen University, ⁵Guangzhou Medical University, ⁶Panzhihua Central Hospital, ⁷Department of Physical Therapy, College of Rehabilitation Sciences, University of Santo Tomas, ⁸Clinical Medical College of Acupuncture and Rehabilitation, Guangzhou University of Traditional Chinese Medicine, ⁹Department of Spine Surgery, Zhongshan Torch Development Zone People's Hospital

This protocol demonstrates the standardized procedure of scalp acupuncture synchronizing motor-cognitive dual task and motor-cognitive dual task. This can provide an important reference for the clinical exploration of the new and effective non-drug treatment of integrated Chinese and Western medicine.