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MacKay Junior College of Medicine, Nursing, and Management

3 ARTICLES PUBLISHED IN JoVE

Medicine

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Hui-Chun Ku¹, Shih-Yi Lee^2,3, Yuan-Kun Aden Wu⁴, Kai-Chien Yang^1,5, Ming-Jai Su¹

¹Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, ²Division of Pulmonary and Critical Care Medicine, Mackay Memorial Hospital, ³Mackay Medicine, Nursing and Management College, ⁴School of Medicine, National Taiwan University, ⁵Department of Internal Medicine, National Taiwan University Hosptial

A rat model of abdominal aortic constriction that induces cardiac hypertrophy and remodeling is described. An efficient, highly-reproducible, and minimally-invasive method is used to provide a simple yet useful platform for research in myocardial hypertrophy and dysfunction.

Medicine

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control

Hui-Chun Ku¹, Ding-Kuo Chien^2,3,4,5, Chuan-Lei Chao^5,6, Shih-Yi Lee^5,7

¹Department of Life Science, Fu Jen Catholic University, ²Department of Medicine, MacKay Medical College, ³Department of Emergency Medicine, MacKay Memorial Hospital, ⁴Graduate Institute of Injury Prevention and Control, Taipei Medical University, ⁵MacKay Junior College of Medicine, Nursing, and Management, ⁶Division of Cardiology, Department of Internal Medicine, Taitung Mackay Memorial Hospital, ⁷Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, MacKay Memorial Hospital

Herein, we present a protocol focusing on the quality control of the left anterior descending coronary artery ligation by technically modifying the traditional procedure in rats for acute myocardial ischemia-reperfusion research.

Medicine

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Hui-Chun Ku¹, Cheng-Wei Huang¹, Shih Yi Lee^2,3

¹Department of Life Science, Fu Jen Catholic University, ²MacKay Junior College of Medicine, Nursing, and Management, ³Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, MacKay Memorial Hospital

This study established a protocol focusing on the technical refinement of a mouse model of bilateral renal ischemia-reperfusion for acute kidney injury research.